Optimising FRET-efficiency of Nd3+-sensitised upconversion nanocomposites by shortening the emitter–photosensitizer distance

Nanoscale ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 8742-8749 ◽  
Author(s):  
Syue-Liang Lin ◽  
Cheng Allen Chang
Keyword(s):  
Energy Transfer ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Forster Resonance Energy Transfer ◽  
Förster Resonance Energy Transfer ◽  
The Core ◽  
Fret Efficiency ◽  
Förster Resonance

Nanocomposite NaYF4:Nd,Yb@Yb@Yb,Er@Y with Nd3+ in the core and Er3+ in the shell to shorten the emitter (Er3+)–photosensitizer distance to achieve better Förster resonance energy transfer (FRET) for better-performing photo-nanotheranostic materials.

scholarly journals Enhancing Förster Resonance Energy Transfer (FRET) Efficiency of Titania–Lanthanide Hybrid Upconversion Nanomaterials by Shortening the Donor–Acceptor Distance

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2035
Author(s):  
Syue-Liang Lin ◽  
Han-Chun Chen ◽  
Cheng Allen Chang
Keyword(s):  
Energy Transfer ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Outer Shell ◽  
Forster Resonance Energy Transfer ◽  
Hybrid Nanocomposites ◽  
Förster Resonance Energy Transfer ◽  
The Core ◽  
Fret Efficiency ◽  
Förster Resonance

Several robust titania (TiO2) coated core/multishell trivalent lanthanide (Ln) upconversion nanoparticles (UCNPs) hybrid architecture designs have been reported for use in photodynamic therapy (PDT) against cancer, utilizing the near-infrared (NIR) excited energy down-shifting and up-conversion chain of Nd3+ (λ793-808 nm) → Yb3+ (λ980 nm) → Tm3+(λ475 nm) → TiO2 to produce reactive oxygen species (ROS) for deep tissue-penetrating oxidative cytotoxicity, e.g., NaLnF4:Yb,Tm (Ln = Y, Gd). Herein, we demonstrate that by doping the Tm3+ emitter ions in the outer shell and the Nd3+ sensitizer ions in the core, the newly designed NaYF4:Nd,Yb@Yb@Yb,Tm@TiO2 hybrid UCNPs exert more ROS production than the reference NaYF4:Yb,Tm@Yb@Nd,Yb@ TiO2 with the Tm3+ ions in the core and the Nd3+ ions in the outer shell, upon 793 nm laser irradiation, primarily due to the shortening of the Tm3+-TiO2 distance of the former with greater Förster resonance energy transfer (FRET) efficiency. After coating with polyallylamine hydrochloride (PAH)/polyethylene glycol folate (PEG-FA), the resulting NaYF4:Nd,Yb@Yb@Yb,Tm@TiO2-PAH-PEG-FA hybrid nanocomposites could be internalized in MDA-MB-231 cancer cells, which also show low dark cytotoxicity and effective photocytotoxicity upon 793 nm excitation. These nanocomposites could be further optimized and are potentially good candidates as nanotheranostics, as well as for other light-conversion applications.

scholarly journals Nanoscale control of single molecule Förster resonance energy transfer by a scanning photonic nanoantenna

Nanophotonics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 4021-4031 ◽  
Author(s):  
Maria Sanz-Paz ◽  
Jerome Wenger ◽  
Niek F. van Hulst ◽  
Mathieu Mivelle ◽  
Maria F. Garcia-Parajo
Keyword(s):  
Energy Transfer ◽  
Near Field ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Forster Resonance Energy Transfer ◽  
Förster Resonance Energy Transfer ◽  
Field Energy ◽  
Fret Efficiency ◽  
Fret Pair ◽  
Förster Resonance

AbstractFörster Resonance Energy Transfer (FRET) is a widely applied technique in biology to accurately measure intra- and inter-molecular interactions at the nanometre scale. FRET is based on near-field energy transfer from an excited donor to a ground state acceptor emitter. Photonic nanoantennas have been shown to modify the rate, efficiency and extent of FRET, a process that is highly dependent on the near-field gradient of the antenna field as felt by the emitters, and thus, on their relative distance. However, most of the experiments reported to date focus on fixed antennas where the emitters are either immobilized or diffusing in solution, so that the distance between the antenna and the emitters cannot be manipulated. Here, we use scanning photonic nanoantenna probes to directly modulate the FRET efficiency between individual FRET pairs with an unprecedented nanometric lateral precision of 2 nm on the antenna position. We find that the antenna acts as an independent acceptor element, competing with the FRET pair acceptor. We directly map the competition between FRET and donor-antenna transfer as a function of the relative position between the antenna and the FRET donor-acceptor pair. The experimental data are well-described by FDTD simulations, confirming that the modulation of FRET efficiency is due to the spatially dependent coupling of the single FRET pair to the photonic antenna.

scholarly journals Förster resonance energy transfer in fluorophore labeled poly(2-ethyl-2-oxazoline)s

2020 ◽  
Vol 8 (40) ◽  
pp. 14125-14137
Author(s):  
Ronald Merckx ◽  
Thomas Swift ◽  
Ryan Rees ◽  
Joachim F. R. Van Guyse ◽  
Ella Schoolaert ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Fluorescent Probe ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Temperature Sensing ◽  
Forster Resonance Energy Transfer ◽  
Förster Resonance Energy Transfer ◽  
Fret Efficiency ◽  
Förster Resonance ◽  
Coumarin 343

A well-defined FRET system based on heterotelechelic poly(2-ethyl-2-oxazoline) containing pyrene and coumarin 343 was successfully used as fluorescent probe for temperature sensing and processed into fibres and films showing excellent FRET efficiency.

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