Near-infrared-excited upconversion photodynamic therapy of extensively drug-resistant Acinetobacter baumannii based on lanthanide nanoparticles

Nanoscale ◽  
2020 ◽  
Vol 12 (26) ◽  
pp. 13948-13957
Author(s):  
Wenzhen Liu ◽  
Yuxiang Zhang ◽  
Wenwu You ◽  
Jianqiang Su ◽  
Shaohua Yu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Acinetobacter Baumannii ◽  
Near Infrared ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Novel Strategy

This work reports a novel strategy to combat extensively drug-resistant Acinetobacter baumannii via NIR-responsive UCNPs-based PDT.

Decreased carO gene expression and OXA-type carbapenemases among extensively drug-resistant Acinetobacter baumannii strains isolated from burn patients in Tehran, Iran

2020 ◽  
Author(s):  
Elham Abbasi ◽  
Hossein Goudarzi ◽  
Ali Hashemi ◽  
Alireza Salimi Chirani ◽  
Abdollah Ardebili ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acinetobacter Baumannii ◽  
High Rate ◽  
Burn Patients ◽  
Drug Resistant ◽  
Disc Diffusion ◽  
Carbapenem Resistant ◽  
Extensively Drug Resistant ◽  
Sds Page ◽  
Extensively Drug Resistance

AbstractA major challenge in the treatment of infections has been the rise of extensively drug resistance (XDR) and multidrug resistance (MDR) in Acinetobacter baumannii. The goals of this study were to determine the pattern of antimicrobial susceptibility, blaOXA and carO genes among burn-isolated A. baumannii strains. In this study, 100 A. baumannii strains were isolated from burn patients and their susceptibilities to different antibiotics were determined using disc diffusion testing and broth microdilution. Presence of carO gene and OXA-type carbapenemase genes was tested by PCR and sequencing. SDS-PAGE was done to survey CarO porin and the expression level of carO gene was evaluated by Real-Time PCR. A high rate of resistance to meropenem (98%), imipenem (98%) and doripenem (98%) was detected. All tested A. baumannii strains were susceptible to colistin. The results indicated that 84.9% were XDR and 97.9% of strains were MDR. In addition, all strains bore blaOXA-51 like and blaOXA-23 like and carO genes. Nonetheless, blaOXA-58 like and blaOXA-24 like genes were harbored by 0 percent and 76 percent of strains, respectively. The relative expression levels of the carO gene ranged from 0.06 to 35.01 fold lower than that of carbapenem-susceptible A. baumannii ATCC19606 and SDS – PAGE analysis of the outer membrane protein showed that all 100 isolates produced CarO. The results of current study revealed prevalence of blaOXA genes and changes in carO gene expression in carbapenem resistant A.baumannii.

scholarly journals Complete Genome Sequences of Four Extensively Drug-Resistant Acinetobacter baumannii Isolates from Thailand

2020 ◽  
Vol 9 (40) ◽  
Author(s):  
Peechanika Chopjitt ◽  
Thidathip Wongsurawat ◽  
Piroon Jenjaroenpun ◽  
Parichart Boueroy ◽  
Rujirat Hatrongjit ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Complete Genome ◽  
Sequence Type ◽  
Clinical Isolates ◽  
Drug Resistant ◽  
Genome Sequences ◽  
Content Type ◽  
Type Isolate ◽  
Resistant Genes ◽  
Extensively Drug Resistant

ABSTRACT Here, we report the complete genome sequences of four clinical isolates of extensively drug-resistant Acinetobacter baumannii (XDRAB), isolated in Thailand. These results revealed multiple antimicrobial-resistant genes, each involving two sequence type 16 (ST16) isolates, ST2, and a novel sequence type isolate, ST1479.

Extensively drug-resistant Acinetobacter baumannii nosocomial pneumonia successfully treated with a novel antibiotic combination

2021 ◽  
Author(s):  
Noor Zaidan ◽  
J. Patrik Hornak ◽  
David Reynoso
Keyword(s):  
Septic Shock ◽  
Drug Development ◽  
Acinetobacter Baumannii ◽  
Nosocomial Infections ◽  
Drug Resistant ◽  
Access Protocol ◽  
The Poor ◽  
Extensively Drug Resistant ◽  
Poor Outcomes ◽  
Antibiotic Combination

Extremely drug resistant (XDR) Acinetobacter baumannii cause challenging nosocomial infections. We report the case of a patient with XDR A. baumannii pneumonia and septic shock successfully treated with cefiderocol and a novel antibiotic obtained via expanded access protocol. With focused research and drug development efforts, the poor outcomes associated with these infections may be mitigated.

scholarly journals Strategies of Treatment for Extensively Drug-Resistant Acinetobacter baumannii Infections: Single Centre Experience

2017 ◽  
Vol 02 (01) ◽  
Author(s):  
Islas Munoz Beda Daniela ◽  
Villegas Acosta Liudmila ◽  
Aguilar Zapata Daniel ◽  
Valdez Vazquez Rafael ◽  
Lopez Escamilla Eduardo ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Drug Resistant ◽  
Single Centre ◽  
Extensively Drug Resistant ◽  
Single Centre Experience
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