Traditional Chinese medicine (TCM) as a source of new anticancer drugs

2021 ◽  
Author(s):  
Chang-liang Yao ◽  
Jian-qing Zhang ◽  
Jia-yuan Li ◽  
Wen-long Wei ◽  
Shi-fei Wu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Anticancer Drugs ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Single Chemical ◽  
New Anticancer Drugs

Drugs derived from traditional Chinese medicines (TCM) include both single chemical entities and multi-component preparations.

scholarly journals Targeting Cancer Metabolism to Resensitize Chemotherapy: Potential Development of Cancer Chemosensitizers from Traditional Chinese Medicines

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 404 ◽  
Author(s):  
Guo ◽  
Tan ◽  
Chen ◽  
Wang ◽  
Feng
Keyword(s):  
Chinese Medicine ◽  
Cancer Therapy ◽  
Traditional Chinese Medicine ◽  
Cancer Cells ◽  
Metabolic Pathways ◽  
Cancer Metabolism ◽  
Metabolic Reprogramming ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Incidence And Mortality

Cancer is a common and complex disease with high incidence and mortality rates, which causes a severe public health problem worldwide. As one of the standard therapeutic approaches for cancer therapy, the prognosis and outcome of chemotherapy are still far from satisfactory due to the severe side effects and increasingly acquired resistance. The development of novel and effective treatment strategies to overcome chemoresistance is urgent for cancer therapy. Metabolic reprogramming is one of the hallmarks of cancer. Cancer cells could rewire metabolic pathways to facilitate tumorigenesis, tumor progression, and metastasis, as well as chemoresistance. The metabolic reprogramming may serve as a promising therapeutic strategy and rekindle the research enthusiasm for overcoming chemoresistance. This review focuses on emerging mechanisms underlying rewired metabolic pathways for cancer chemoresistance in terms of glucose and energy, lipid, amino acid, and nucleotide metabolisms, as well as other related metabolisms. In particular, we highlight the potential of traditional Chinese medicine as a chemosensitizer for cancer chemotherapy from the metabolic perspective. The perspectives of metabolic targeting to chemoresistance are also discussed. In conclusion, the elucidation of the underlying metabolic reprogramming mechanisms by which cancer cells develop chemoresistance and traditional Chinese medicines resensitize chemotherapy would provide us a new insight into developing promising therapeutics and scientific evidence for clinical use of traditional Chinese medicine as a chemosensitizer for cancer therapy.

scholarly journals Arsenic Bioaccessibility of Realgar Influenced by the Other Traditional Chinese Medicines in Niuhuang Jiedu Tablet and the Roles of Gut Microbiota

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Wenfeng Xu ◽  
Shuo Xu ◽  
Shanshan Zhang ◽  
Xuejun Wu ◽  
Pengfei Jin
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gut Microbiota ◽  
Incubation Medium ◽  
Toxic Elements ◽  
The Other ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Scutellariae Radix

Niuhuang Jiedu tablet (NJT), a realgar (As2S2) containing Traditional Chinese Medicine (TCM), is a well-known formula. The safety of NJT is of growing concern since arsenic (As) is considered as one of the most toxic elements. NJT was demonstrated to be safer than realgar by our previous experiments and some other studies. The toxicity of realgar has been shown to be related to the amount of soluble or bioaccessible arsenic. In this study, the influences of the other TCMs in NJT on the bioaccessibility of arsenic from realgar, and the roles of gut microbiota during this process were investigated in vitro. Results showed that Dahuang (Rhei Radix et Rhizoma), Huangqin (Scutellariae Radix), Jiegeng (Platycodonis Radix), and Gancao (Glycyrrhizae Radix et Rhizoma) could significantly reduce the bioaccessibility of arsenic from realgar in artificial gastrointestinal fluids. Gut microbiota played an important role in decreasing the bioaccessibility of realgar because it was demonstrated to be able to absorb the soluble arsenic from realgar in the incubation medium. Dahuang, Huangqin, and Jiegeng could modulate the gut microbiota to enhance its arsenic absorption activity.

Hemagglutination Characterization of Lectins from Four Traditional Chinese Medicines

2013 ◽  
Vol 634-638 ◽  
pp. 1309-1312
Author(s):  
Hui Jun Yuan ◽  
Ai Mei Yang ◽  
Hui Ling Gong ◽  
Jing Hu ◽  
Jing Ting Bao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Hemagglutination Titer

Hemagglutination titer of crude lectin from four traditional chinese medicine was detected. Lectins from Radix Polygalae and Saxifraga stolonifera agglutinated red blood cells of rabbit, rat and chook potently. Heteropappus hispidus (Thunb.) Less lectin also agglutinated the three kinds of red blood cells, but hemagglutination titer was lower. Hemagglutination effect of Lepisorus waltonii (Ching) Ching lectin only appeared in rat red blood cells.

Effects of Traditional Chinese Medicines on Murine Bone Metabolism in a Microgravity Environment

2003 ◽  
Vol 31 (05) ◽  
pp. 739-749 ◽  
Author(s):  
Qing-Hua Song ◽  
Takao Kobayashi ◽  
Takayuki Hosoi ◽  
Jong-Chol Cyong
Keyword(s):  
Alkaline Phosphatase ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Bone Metabolism ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Space Environment ◽  
Microgravity Environment ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines

We investigated the effects of three traditional Chinese medicine prescriptions on changes of bone metabolism in mice, using a gravity device to produce a microgravity environment. We found that Hochu-ekki-to (TJ-41) and Hachimi-jio-gan (TJ-7) suppress the increase in the ratio of serum Ca/P and the increase of calcium in urine. Moreover, TJ-41 and Shin-bu-to (TJ-30) reversed the increase of alkaline phosphatase activity (ALP), and TJ-41 also reversed the decrease of estradiol in the serum. The mechanism may be that the traditional Chinese medicines increased estradiol, causing the decrease of ALP, which induced the changes of Ca and P in serum, leading to a decreased excretion of Ca in urine. In this study, TJ-41 was effective in every parameter while TJ-7 and TJ-30 was effective on some parameters, showing that traditional Chinese medicines have specificities in the space environment. In conclusion, this study suggests that some traditional Chinese medicines may be beneficial for adaptation to a space environment.

THE FERMENTATION PROCESSING OF TRADITIONAL CHINESE MEDICINE: A SHORT REVIEW

2021 ◽  
pp. 48-51
Author(s):  
Saeed Hamid Saeed Omer ◽  
YUAN Yanzhi ◽  
LI Gaoqiang ◽  
LIU Yongli ◽  
GAO Wenlong ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Mode Of Action ◽  
Fermentation Process ◽  
Short Review ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Fermentation Liquid ◽  
Solid Fermentation ◽  
Selection Of

In recent decades, the processing of traditional Chinese medicines has received widespread attention as people's requirements for safety and effectiveness of traditional Chinese medicine have increased. Because of its theory and technical methods, the fermentation processing of traditional Chinese medicines has been distinct from other methods. Based on generalized fermentation, the fermentation of traditional Chinese medicine is based on collection of appropriate traditional Chinese medicinal materials for processing according to the characteristics of the bacteria, so that the original properties of the medicinal materials are modied and the effectiveness is increased. Strong fermentation, liquid fermentation, and two-way solid fermentation are popular fermentation methods. Currently, the study of traditional Chinese medicine's fermentation process has drawn wide interest from academics. In the future, in order to open up new avenues for fermentation and production of traditional Chinese medicine, the selection of fermenting microorganisms and the mode of action of strains in the fermentation phase need to be examined in depth.

scholarly journals The Traditional Chinese Medicine and Relevant Treatment for the Efficacy and Safety of Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2017 ◽  
Vol 2017 ◽  
pp. 1-20 ◽  
Author(s):  
Zhao-feng Shi ◽  
Tie-bing Song ◽  
Juan Xie ◽  
Yi-quan Yan ◽  
Yong-ping Du
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Control Group ◽  
Controlled Trials ◽  
Traditional Chinese Medicines ◽  
Efficacy And Safety ◽  
Chinese Medicines ◽  
Randomized Controlled

Background. Atopic dermatitis (AD) has become a common skin disease that requires systematic and comprehensive treatment to achieve adequate clinical control. Traditional Chinese medicines and related treatments have shown clinical effects for AD in many studies. But the systematic reviews and meta-analyses for them are lacking. Objective. The systematic review and meta-analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement were conducted to evaluate the efficacy and safety of traditional Chinese medicines and related treatments for AD treatment. Methods. Randomized controlled trials (RCTs) were searched based on standardized searching rules in eight medical databases from the inception up to December 2016 and a total of 24 articles with 1,618 patients were enrolled in this meta-analysis. Results. The results revealed that traditional Chinese medicines and related treatments did not show statistical differences in clinical effectiveness, SCORAD amelioration, and SSRI amelioration for AD treatment compared with control group. However, EASI amelioration of traditional Chinese medicines and related treatments for AD was superior to control group. Conclusion. We need to make conclusion cautiously for the efficacy and safety of traditional Chinese medicine and related treatment on AD therapy. More standard, multicenter, double-blind randomized controlled trials (RCTs) of traditional Chinese medicine and related treatment for AD were required to be conducted for more clinical evidences providing in the future.

Retrospective Case Series: TCM Therapy Improves Autism/ADHD-Like Behavior in Food Allergic Children

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Zambrano L ◽  
◽  
Neshiwat J ◽  
Primas M, ◽  
Kroner A ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Case Series ◽  
Behavioral Changes ◽  
Behavioral Symptoms ◽  
Traditional Chinese Medicines ◽  
Retrospective Case ◽  
Chinese Medicines ◽  
Retrospective Case Series ◽  
Potential Remedy

Allergens can produce sensory, neurological, and behavioral changes, especially in children diagnosed with autism and/or ADHD. Certain Traditional Chinese Medicines may reduce allergic sensitivity/inflammation and alleviate autism/ADHD like behavioral symptoms. This is a retrospective case series on two patients with allergies, gastrointestinal issues and Autism/Autismlike who had improved behaviors and allergies after a Traditional Chinese Medicine (TCM) regimen. Two patients with autism-ADHD/autism-ADHD-like behaviors and severe allergies were treated using TCM to reduce their allergies and improve their behavior. These effects were achieved when the correct concentrations and doses of a series of TCM teas and treatments were reached. TCM appeared to be safe and well tolerated. TCM significantly improved the behaviors and allergies of both patients, therefore TCM may be a potential remedy for sensory issues, neurological problems and behavioral changes associated with allergies.

scholarly journals The Antitumor Efficacy of β-Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment

2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
Qiang Xie ◽  
Fengzhou Li ◽  
Lei Fang ◽  
Wenzhi Liu ◽  
Chundong Gu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cancer Cells ◽  
Traditional Chinese Medicines ◽  
Active Ingredients ◽  
Antitumor Effects ◽  
Tumor Immune Escape ◽  
Chinese Medicines ◽  
Inflammatory Microenvironment ◽  
Anti Inflammatory

Inflammatory mediators and inflammatory cells in the inflammatory microenvironment promote the transformation of normal cells to cancer cells in the early stage of cancer, promote the growth and development of cancer cells, and induce tumor immune escape. The monomeric active ingredient β-elemene is extracted from the traditional Chinese medicine Curcuma wenyujin and has been proven to have good anti-inflammatory and antitumor activities in clinical applications for more than 20 years in China. Recent studies have found that this traditional Chinese medicine plays a vital role in macrophage infiltration and M2 polarization, as well as in regulating immune disorders, and it even regulates the transcription factors NF-κB and STAT3 to alter inflammation, tumorigenesis, and development. In addition, β-elemene regulates not only different inflammatory factors (such as TNF-α, IFN, TGF-β, and IL-6/10) but also oxidative stress in vivo and in vitro. The excellent anti-inflammatory and antitumor effects of β-elemene and its ability to alter the inflammatory microenvironment of tumors have been gradually elaborated. Although the study of monomeric active ingredients in traditional Chinese medicines is insufficient in terms of quality and quantity, the pharmacological effects of more active ingredients of traditional Chinese medicines will be revealed after β-elemene.

scholarly journals Science Communication in the Debate about ‘Poison’ in Traditional Chinese Medicine

2019 ◽  
Vol 2 (2) ◽  
pp. 97-107
Author(s):  
Liyuan Yue ◽  
Bing Liu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Science Communication ◽  
Aristolochic Acid ◽  
Safety Issue ◽  
Herbal Remedies ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Wide Debate ◽  
Tv Show

At the end of 2017, research revealed that herbal remedies containing aristolochic acid may cause liver cancer. This triggered a wide debate on ‘poison’ in traditional Chinese medicine. The popular TV show A Bite of China 3 also put the safety issue of traditional Chinese medicines as tonic food in the spotlight of public opinion. In fact, there are many misunderstandings about poison in descriptions of food safety and medicine safety on the internet and WeChat. From the perspective of science communication, our understanding of poison and its uses should transcend the monism of Western science.

scholarly journals A Survey of Chinese Herbal Medicine Intake Amongst Preoperative Patients in Hong Kong

2005 ◽  
Vol 33 (4) ◽  
pp. 506-513 ◽  
Author(s):  
L. A. H. Critchley ◽  
D. Q. Chen ◽  
A. Lee ◽  
G. N. Thomas ◽  
B. Tomlinson
Keyword(s):  
Hong Kong ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Odds Ratio ◽  
Medical Practitioner ◽  
Chinese Herbs ◽  
Herbal Remedies ◽  
Chinese Patients ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines

We have surveyed, by means of a questionnaire, the preoperative use of traditional Chinese medicines in 259 adult Chinese patients admitted to a Hong Kong teaching hospital. The spectrum and use of herbal remedies differed from that reported by Western sources. Of those patients surveyed 90% used Chinese herbs on a regular daily basis in traditional soups and teas while 44% had consulted a traditional Chinese medicine practitioner in the last twelve months prior to admission, but mainly for health promotion (59%) and minor ailments (30%). Only 25% sought advice for their current illness and 13% were taking regular traditional Chinese medicines prior to admission. The ingredients were difficult to identify. Patients with cancer were more likely to use ling zhi (odds ratio 5.4). Female patients with reproductive problems were more likely to visit a traditional Chinese medical practitioner (odds ratio 2.6) and use ginseng (odds ratio 5.1). The anaesthetic implications of preoperative traditional Chinese medicine in keeping with Hong Kong practices need to be investigated, and appropriate anaesthetic guidelines should be developed.

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