In silico-driven identification of novel molluscicides effective against Biomphalaria glabrata (Say, 1818)

2020 ◽  
Vol 44 (39) ◽  
pp. 16948-16958
Author(s):  
Daniela Braz dos Santos ◽  
José Teófilo Moreira-Filho ◽  
Amanda de Oliveira Melo ◽  
Josiel Araújo Lemes ◽  
Luciana Damacena Silva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intermediate Host ◽  
In Silico ◽  
Biomphalaria Glabrata ◽  
Freshwater Ecosystem ◽  
Schistosomiasis Control ◽  
Endemic Areas ◽  
Transmission Of Disease

Schistosomiasis control in endemic areas depends on several factors, including mass drug delivery programs and interrupting the transmission of disease by controlling the intermediate host snails in the freshwater ecosystem using molluscicides.

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

Nanoscale Drug Delivery Systems for Glaucoma: Experimental and In Silico Advances

2020 ◽  
Vol 20 ◽  
Author(s):  
Smriti Sharma ◽  
Vinayak Bhatia
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
The Body ◽  
Single Wall Carbon Nanotubes ◽  
Blood Retinal Barrier ◽  
Novel Drugs ◽  
Blood Aqueous Barrier

: In this review nanoscale based drug delivery systems particularly in relevance to the antiglaucoma drugs have been discussed. In addition to that, the latest computational/in silico advances in this field are examined in brief. Using nanoscale materials for drug delivery, is an ideal option to target tumours and drug can be released at areas of the body where traditional drugs may fail to act. Nanoparticles, polymeric nanomaterials, single-wall carbon nanotubes (SWCNTs), quantum dots (QDs), liposomes and graphene are the most important nanomaterials used for drug delivery. Ocular drug delivery is one of the most common and difficult tasks faced by pharmaceutical scientists because of many challenges like circumventing the blood–retinal barrier, corneal epithelium and the blood–aqueous barrier. Authors found compelling empirical evidence of scientists relying on in-silico approaches to develop novel drugs and drug delivery systems for treating glaucoma. This review in nanoscale drug delivery systems will help us in understand the existing queries and evidence gaps and will pave way for effective design of novel ocular drug delivery systems

scholarly journals Activities of naphthoquinones against Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae), vector of dengue and Biomphalaria glabrata (Say, 1818), intermediate host of Schistosoma mansoni

Acta Tropica ◽  
2009 ◽  
Vol 111 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Karlos A.L. Ribeiro ◽  
Cenira Monteiro de Carvalho ◽  
Maria Teresa Molina ◽  
Estelita Pereira Lima ◽  
Eulogio López-Montero ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Schistosoma Mansoni ◽  
Intermediate Host ◽  
Biomphalaria Glabrata

In vitro and in silico investigations of drug delivery via zeolite BEA

2011 ◽  
Vol 21 (21) ◽  
pp. 7789 ◽  
Author(s):  
Dimitrios G. Fatouros ◽  
Dennis Douroumis ◽  
Vladimiros Nikolakis ◽  
Spyridon Ntais ◽  
Anastasia Maria Moschovi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Silico

scholarly journals Female biased sex-ratio in Schistosoma mansoni after exposure to an allopatric intermediate host strain of Biomphalaria glabrata

2013 ◽  
Vol 135 (2) ◽  
pp. 350-356 ◽  
Author(s):  
Julie M.J. Lepesant ◽  
Jérôme Boissier ◽  
Déborah Climent ◽  
Céline Cosseau ◽  
Christoph Grunau
Keyword(s):  
Sex Ratio ◽  
Schistosoma Mansoni ◽  
Intermediate Host ◽  
Biomphalaria Glabrata ◽  
Host Strain ◽  
Biased Sex Ratio

scholarly journals The behavioral effects of antibiotic treatment on the snailBiomphalaria glabrata

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e4171 ◽  
Author(s):  
Euan R.O. Allan ◽  
Michael S. Blouin
Keyword(s):  
Tissue Culture ◽  
Intermediate Host ◽  
Antibiotic Treatment ◽  
New World ◽  
Biomphalaria Glabrata ◽  
Behavioral Effects ◽  
Neglected Tropical Disease ◽  
Intermediate Hosts ◽  
And Control ◽  
Main Model

Schistosomiasis is a detrimental neglected tropical disease that is transmitted by Planorbid snails. Understanding the transmission and control of this disease requires an extensive understanding of these intermediate hosts, which is only achieved by the effective rearing and study of species such asBiomphalaria glabrata. This species is the intermediate host forSchistosoma mansoniin the New World, and is also the main model for studying schistosomes in mollusks. Antibiotics are used routinely inB. glabratatissue culture, and occasionally on live snails. Here we show that standard doses of three common antibiotics (penicillin, streptomycin and gentamicin) drastically diminish the activity of healthyB. glabrata, but that treated snails recover rapidly when placed in fresh water. Ampicillin treated snails did not show altered activity. We suggest that researchers keep these apparent toxicities in mind if a need for antibiotic treatment of live Planorbid snails arises.

The influence of second intermediate host species on the infectivity of metacercarial cysts of Echinoparyphium recurvatum

1999 ◽  
Vol 73 (2) ◽  
pp. 143-145 ◽  
Author(s):  
A.M. McCarthy
Keyword(s):  
Intermediate Host ◽  
Definitive Host ◽  
Host Species ◽  
Post Infection ◽  
Rana Temporaria ◽  
Biomphalaria Glabrata ◽  
Reproductive Status ◽  
Intermediate Hosts ◽  
Potential Influence ◽  
Second Intermediate Host

The potential influence of second intermediate host species on the infectivity of metacercarial cysts of Echinoparyphium recurvatum to the definitive host Anas platyrhynchos was examined experimentally. Echinoparyphium recurvatum metacercarial cysts were obtained from the following experimentally infected second intermediate hosts 14 days post expsoure to cercariae: Lymnaea peregra; Physa fontinalis; L. stagnalis;Planorbis planorbis; Biomphalaria glabrata; tadpoles of the amphibian Rana temporaria. Metacercarial cysts from each of these hosts were fed, in doses of 50 cysts per individual, to separate groups composed of between four and eight, 3-day-old A. platyrhynchos ducklings. All A. platyrhynchos were necropsied 15 days post-infection and the number, size, and reproductive status of E. recurvatum worms in the intestine was recorded. Analyses of variance on the number (transformed log (x + 1)) and size of worms revealed no significant differences in worms originating from metacercariae formed in the different second intermediate hosts (worm number P > 0.05, and worm size P > 0.05). All worms recovered were found to be gravid. It is therefore concluded that the species of second intermediate host utilized does not influence the infectivity of the metacercarial cyst of E. recurvatum, nor the subsequent establishment and reproductive status of the parasite in A. platyrhynchos.

Molluscicidal activity of polyvinylpyrrolidone (PVP)-functionalized silver nanoparticles to Biomphalaria glabrata: Implications for control of intermediate host snail of Schistosoma mansoni

Acta Tropica ◽  
2020 ◽  
Vol 211 ◽  
pp. 105644 ◽  
Author(s):  
Paula Sampaio Araújo ◽  
Maxwell Batista Caixeta ◽  
Rafaella da Silva Brito ◽  
Bruno Bastos Gonçalves ◽  
Sueli Maria da Silva ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Schistosoma Mansoni ◽  
Intermediate Host ◽  
Biomphalaria Glabrata ◽  
Intermediate Host Snail ◽  
Host Snail ◽  
Molluscicidal Activity
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