scholarly journals Synthesis of unsymmetrical 1,8-naphthyridine-based ligands for the assembly of tri-and tetra-nuclear copper(ii) complexes

2020 ◽  
Vol 44 (39) ◽  
pp. 16713-16720
Author(s):  
Felix Bacher ◽  
James A. Isaac ◽  
Christian Philouze ◽  
David Flot ◽  
Aurore Thibon-Pourret ◽  
...  
Keyword(s):  
Amide Group ◽  
Imine Group ◽  
Trinuclear Complexes

Exploring copper(ii) coordination from a new unsymmetrical naphthyridine-based ligand leads to the preparation of tetranuclear and trinuclear complexes. During the complexation, one imine group is oxidized to an amide group.

Synthesis and Biological Properties of some New Lead Sulphonamide and Carboxamide Scaffolds Bearing Coumarin Moiety (Mini Review)

2020 ◽  
Vol 20 ◽  
Author(s):  
Cosmas Chinweike Eze ◽  
Mercy Amarachukwu Ezeokonkwo ◽  
Benjamin Ebere Ezema ◽  
Abraham Efeturi Onoabedje ◽  
David Izuchukwu Ugwu
Keyword(s):  
Biological Properties ◽  
Therapeutic Agents ◽  
Amide Group ◽  
Pharmacological Properties ◽  
Important Class ◽  
Synthetic Route ◽  
Therapeutic Activities

: Coumarin, sulphonamide and amide scaffolds exhibit diverse pharmacological features and constitute an important class of therapeutic agents. In this review, we have discussed the synthesis, biological properties, and SAR of coumarins containing sulphonamide or amide group in the last seven years. Many reviews on the therapeutic activities of coumarins, sulphonamides, and amides have been published, hence the authors focused on coumarin-linked sulphonamide or amide scaffolds. The review provides information on the synthetic route to new coumarins containing sulphonamide or amide groups with improved pharmacological properties.

Microwave Irradiation Syntheses and Crystal Structures of Two Series of Novel Fivemembered Heterocyclic Mono-Imine Compounds

2019 ◽  
Vol 16 (3) ◽  
pp. 444-448 ◽  
Author(s):  
Biyun Su ◽  
Yaning Li ◽  
Dandan Pan ◽  
Paison Faida ◽  
Tingyu Yan ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Aromatic Amines ◽  
Imine Group ◽  
Polymerization Catalysis ◽  
Elementary Analysis ◽  
Toluene Sulfonic Acid ◽  
Ft Ir ◽  
Coordination Ability ◽  
Imine Compounds ◽  
Late Transition

Aim and Objective: The late transition metal complexes with five-membered heterocyclic mono-imine ligands have attracted much attention because of their potential application in olefin polymerization catalysis. In order to increase the coordination ability of heteroatom N and S to center metals, CH3 group was introduced into the side arm of pyrrole imine and thiophene imine respectively, to get two series of novel five-membered heterocyclic imine compounds, mono(imino)pyrroles and mono(imino)thiophenes Materials and Methods: Two series of novel five-membered heterocyclic compounds with the mono-imine group were synthesized from the p-toluene sulfonic acid catalyzed Schiff base condensation of aromatic amines and 2-acetylpyrrole/ 2-acetylthiophene respectively, using CH3 group to substitute the common H atom on the side arm of pyrrole imine/ thiophene imine. Results: All the heterocyclic mono-imine compounds were characterized adequately by means of 1H NMR, 13C NMR, FT-IR, elementary analysis, as well as X-ray crystallographic diffraction. The reactivity differences between two precursor 2-acetylpyrrole and 2-acetylthiophene with aromatic amines were compared and discussed in detail. Conclusion: Compared to traditional heating methods, the solvent-free microwave irradiation seemed more efficient to prepare these series of five-membered heterocyclic mono-imine compounds, which resulted in a higher yield and cleaner product.

(Substituted)-benzo[b]thiophene-4-carboxamide Synthesis and Antiproliferative Activity Study

2020 ◽  
Vol 17 (5) ◽  
pp. 563-573 ◽  
Author(s):  
Chandrakant Dhondiram Pawar ◽  
Dattatraya Navnath Pansare ◽  
Devanand Baburao Shinde
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Proliferative Activity ◽  
Thiophene Ring ◽  
Amide Group ◽  
Peptide Coupling ◽  
Ic50 Value ◽  
Important Building Block ◽  
Mcf 7

Background: Thiophene ring forms important building block in medicinal chemistry. Literature reveals that thiophene ring in combination with different groups shows different activity. By keeping these things in mind we have designed and synthesized a new series of amide and sulfonamide coupled thiophene. A series of novel substituted 3-sulfamoylbenzo[b]thiophene-4- carboxamide molecules containing sulfonamide and amide group were designed, synthesized and used for anti-proliferative activity study. Methods: The final compounds 16-36 were synthesized by using series of reactions comprising sulfonation, sulfonamide coupling, hydrolysis and peptide coupling. The yields of compounds 16- 36 are in the range of 90-98%. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR, LCMS and the purity was checked through HPLC analysis. The compounds were further tested for their in vitro anticancer activity against a series of cell lines A549, HeLa, MCF-7 and Du-145. Results: The intermediates 8-13, 15 and final compounds 16-36 were synthesized in good yields. The synthesized compounds were further tested for their anticancer activity and most of compounds showed moderate to good anticancer activity against all four cell lines. Conclusion: We have synthesized 21 compounds and were screened for anticancer activity against MCF-7, HeLa, A-549 and Du-145 cancer cell lines. Most of the compounds were active for tested cell lines with IC50 value in the range of 1.81 to 9.73 μM. The compounds 18, 19, 21, 25, 30, 31 and 33 are most active in cell line data with IC50 value in the range of 1.81 to 2.52 μM.

Electronic and steric impact of bis-NHC ligands on reactions of Pt3S2 cores in trinuclear complexes bearing bis-NHC ligands with various lengths of alkylene bridges

2021 ◽  
Vol 50 (35) ◽  
pp. 12079-12082
Author(s):  
Natsuki Yabune ◽  
Hiroshi Nakajima ◽  
Takanori Nishioka
Keyword(s):  
Steric Hindrance ◽  
Trinuclear Complexes

A silver(i) ion attacks the sulfide ligand of a triplatinum complex bearing ethylene-bridged bis-NHC ligands to afford a heptanuclear complex with two Ag–S bonds due to the steric hindrance of the ligands covering the Pt–Pt bonds.

Catalysis of sulfonate ester hydrolysis by an intramolecular amide group assistance

1985 ◽  
Vol 50 (18) ◽  
pp. 3336-3341 ◽  
Author(s):  
Sergio Thea ◽  
Giuseppe Guanti ◽  
Andrew R. Hopkins ◽  
Andrew Williams
Keyword(s):  
Ester Hydrolysis ◽  
Amide Group ◽  
Sulfonate Ester

Inhibited rotation of amide group around C N bond of nicotinamide in different solvents by 1 H NMR data

2017 ◽  
Vol 231 ◽  
pp. 238-241 ◽  
Author(s):  
G.A. Gamov ◽  
V.V. Aleksandriiskii ◽  
V.A. Sharnin
Keyword(s):  
Amide Group ◽  
H Nmr ◽  
Nmr Data
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