An efficient synthesis of chloro-aminocyclooctanediol and aminocyclooctanetriol: an unexpected acetolysis product

2020 ◽  
Vol 44 (41) ◽  
pp. 17976-17983
Author(s):  
Ufuk Nusret Karavaizoglu ◽  
Emine Salamci
Keyword(s):  
Ring Opening ◽  
Efficient Synthesis ◽  
Hydride Shift ◽  
Ring Opening Reaction

A concise and efficient synthesis of 2-amino-4-chlorocyclooctanediol, aminocyclooctanetriols and unusual 1,3-hydride shift during the ring opening reaction of epoxide is described.

Design, synthesis and evaluation of structurally diverse ortho-acylphenol-diindolylmethane hybrids as anticancer agents

2022 ◽  
Author(s):  
Zhi-Gang Yin ◽  
Xiong-Wei Liu ◽  
Hui-Juan Wang ◽  
Min Zhang ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Anticancer Agents ◽  
Nucleophilic Addition ◽  
Ring Opening ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Design Synthesis ◽  
Pyrone Ring ◽  
Ring Opening Reaction ◽  
First Time

A highly efficient synthesis of structurally diverse ortho-acylphenol–diindolylmethane hybrids 3 using carboxylic acid-activated chromones as versatile synthetic building blocks is reported here for the first time, through 1,4-nucleophilic addition and followed by a decarboxylation and pyrone ring opening reaction process.

An efficient synthesis of imidodicarbonic diamides from 1,3-thiazetidin-2-ones with NH2OH·HCl via ring-opening reaction

2015 ◽  
Vol 26 (1) ◽  
pp. 85-88 ◽  
Author(s):  
Wen-Yuan Tang ◽  
Jing-Jing Guo ◽  
Xing-Xing Gui ◽  
De-Man Han ◽  
Jian-Jun Li
Keyword(s):  
Ring Opening ◽  
Efficient Synthesis ◽  
Ring Opening Reaction

Regio- and Stereoselective Synthesis of a Novel Family of Unsaturated Compounds with the S–Se Bond and Their Cyclization to 2,3-Dihydro-1,4-thiaselenines

Synthesis ◽  
2019 ◽  
Vol 51 (08) ◽  
pp. 1832-1840 ◽  
Author(s):  
Svetlana Amosova ◽  
Andrey Filippov ◽  
Vladimir Potapov ◽  
Maxim Penzik ◽  
Nataliya Makhaeva ◽  
...  
Keyword(s):  
Ring Opening ◽  
Room Temperature ◽  
Stereoselective Synthesis ◽  
Reaction Times ◽  
Nucleophilic Attack ◽  
Selenium Atom ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Ring Opening Reaction ◽  
Acid Catalyzed

Regio- and stereoselective ring-opening reaction of 2-bromomethyl-1,3-thiaselenole with thiols proceeded as nucleophilic attack at the selenium atom of seleniranium intermediate affording unsaturated selanyl sulfides, (Z)-CH2=CHSCH=CHSeSR, in up to 93% yield. Dithiols were involved in this reaction giving symmetrical polyunsaturated compounds with two S–Se bonds in 70–75% yields. Efficient synthesis of 2-(organylsulfanyl)-2,3-dihydro-1,4-thiaselenines in 69–96% yields was developed by the acid-catalyzed cyclization of the unsaturated selanyl sulfides. Mild reaction conditions (room temperature) and short reaction times are important features of this methodology.

ChemInform Abstract: An Efficient Synthesis of Imidodicarbonic Diamides from 1,3-Thiazetidin-2-ones with NH2OH·HCl via Ring-Opening Reaction.

ChemInform ◽  
2015 ◽  
Vol 46 (21) ◽  
pp. no-no
Author(s):  
Wen-Yuan Tang ◽  
Jing-Jing Guo ◽  
Xing-Xing Gui ◽  
De-Man Han ◽  
Jian-Jun Li
Keyword(s):  
Ring Opening ◽  
Efficient Synthesis ◽  
Ring Opening Reaction

Efficient Synthesis of Fluorophosphonylated Alkyles by Ring-Opening Reaction of Cyclic Sulfates

2008 ◽  
Vol 10 (17) ◽  
pp. 3895-3898 ◽  
Author(s):  
Sonia Amel Diab ◽  
Aboubacary Sene ◽  
Emmanuel Pfund ◽  
Thierry Lequeux
Keyword(s):  
Ring Opening ◽  
Efficient Synthesis ◽  
Ring Opening Reaction ◽  
Cyclic Sulfates
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