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An efficient methodology for the synthesis of 1,3-thiazolidin-4-ones using L-Proline as catalyst under aqueous
conditions has been developed. The one-pot, multicomponent reaction of aromatic/heterocyclic aldehyde, aromatic amine
and thioglycolic acid at room temperature give 1,3-thiazolidin-4-ones in moderate to good yields. Further, the current approach is notably greener than traditional methods with E-factor of 3.1 and the eco scale score of 96. The developed protocol
offers several features, such as being simple, environmentally benign, energy-efficient, economical, mild conditions, shorter
reaction time.