Improved, gram-scale synthesis of sildenafil in water using arylacetic acid as the acyl source in the pyrazolo[4,3-d]pyrimidin-7-one ring formation

2020 ◽  
Author(s):  
Joydev K. Laha ◽  
Upma Gulati ◽  
SAIMA Malik ◽  
Anjali Gupta ◽  
Harish Kumar Indurthi

An improved, gram-scale synthesis of the blockbuster drug sildenafil, used for the treatment of male erectile dysfunction, has been developed. Unlike the previous literature, the current method demonstrates the use...

Phytomedicine ◽  
2009 ◽  
Vol 16 (8) ◽  
pp. 690-693 ◽  
Author(s):  
Ali Shamsa ◽  
Hossein Hosseinzadeh ◽  
Mahmood Molaei ◽  
Mohammad Taghi Shakeri ◽  
Omid Rajabi

2002 ◽  
Vol 162 (12) ◽  
pp. 1349 ◽  
Author(s):  
Howard A. Fink ◽  
Roderick Mac Donald ◽  
Indulis R. Rutks ◽  
David B. Nelson ◽  
Timothy J. Wilt

2020 ◽  
Vol 130 ◽  
pp. 110555 ◽  
Author(s):  
Nelisiwe Prenate Masuku ◽  
Jeremiah Oshiomame Unuofin ◽  
Sogolo Lucky Lebelo

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