Improved, gram-scale synthesis of sildenafil in water using arylacetic acid as the acyl source in the pyrazolo[4,3-d]pyrimidin-7-one ring formation
Keyword(s):
An improved, gram-scale synthesis of the blockbuster drug sildenafil, used for the treatment of male erectile dysfunction, has been developed. Unlike the previous literature, the current method demonstrates the use...
1998 ◽
Vol 20
(6)
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pp. 1033-1048
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Keyword(s):
2003 ◽
Vol 12
(9)
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pp. 1521-1533
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2012 ◽
Vol 31
(3)
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pp. 591-595
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Keyword(s):
2002 ◽
Vol 162
(12)
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pp. 1349
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