Copper(ii) complexes containing enoxacin and heterocyclic ligands: synthesis, crystal structures and their biological perspectives

2020 ◽  
Vol 44 (20) ◽  
pp. 8595-8613 ◽  
Author(s):  
Manish Kumar ◽  
Gyanendra Kumar ◽  
Dhanraj T. Masram
Keyword(s):  
Cancer Cells ◽  
Crystal Structures ◽  
Heterocyclic Ligands ◽  
Pyramidal Geometry ◽  
Square Pyramidal Geometry ◽  
Mcf 7

Two copper-based complexes with a distorted square pyramidal geometry show excellent binding and cleavage affinity towards DNA and proteins. Also, these complexes have potential cytotoxicity against MCF-7 cancer cells.

Synthesis and photodynamic activities of a new metronidazole-appended porphyrin and its Zn(II) complex

2015 ◽  
Vol 19 (10) ◽  
pp. 1107-1113 ◽  
Author(s):  
Qiong Yu ◽  
Wei-Xia Xu ◽  
Ya-Hong Yao ◽  
Zeng-Qi Zhang ◽  
Shu Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Crystal Structure ◽  
Oxygen Atom ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Porphyrin Ring ◽  
H Nmr ◽  
Pyramidal Geometry ◽  
Photodynamic Activity ◽  
Square Pyramidal Geometry

One novel porphyrin 5,10,15-tris(phenyl)-20-[4-(2-(2-methyl-5-nitro-imidazolyl)ethoxyl)phenyl] porphyrin and its zinc(II) metalloporphyrin were synthesized and characterized by IR, UV-vis, 1H NMR, MS and elemental analysis. The single crystal structure of zinc(II) porphyrin shows that the Zn(II) ion is coordinated with four nitrogen atoms of porphyrin ring and one oxygen atom of ethanol from axial, forming a five-coordinated square pyramidal geometry. Their cytotoxicity and photodynamic activity against breast cancer cells were studied. The results indicate that both of the porphyrins display high phototoxicity to the breast cancer cells with the negligible dark toxicity. In addition, the photodynamic activity of zinc(II) porphyrin was obviously higher than that of the free porphyrin.

Die Kristallstrukturen von (η5-C5Me5)MoMe4 und (η5-C5Me5)WMe4 / The Crystal Structures of (η5-C5Me5)MoMe4 and (η5-C5Me5)WMe4

1995 ◽  
Vol 50 (8) ◽  
pp. 1207-1209 ◽  
Author(s):  
Katrin Köhler ◽  
Alexander Steiner ◽  
Herbert W. Roesky
Keyword(s):  
Crystal Structures ◽  
Lattice Parameters ◽  
Orthorhombic Space Group ◽  
Space Group ◽  
Pyramidal Geometry ◽  
Square Pyramidal Geometry

The crystal structures of (η5-C5Me5)MoMe4 1 and (η5-C5Me5)WMe4 2 are reported. 1 and 2 crystallize in the orthorhombic space group Pbcm with the lattice parameters a = 681.4(2) pm, b = 1538.6(6) pm, c = 1402.4(6) pm with 4 units per cell (1), and a = 684.99(6) pm, b = 1547.3(2) pm, c = 1405.5(2) pm with 4 units per cell (2). Both compounds are monomeric and have a square-pyramidal geometry.

scholarly journals Novel (N4) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity

2018 ◽  
Vol 5 (1) ◽  
pp. 51-63 ◽  
Author(s):  
Hanaa A. El-Boraey ◽  
Ohyla A. EL-Gammal
Keyword(s):  
Condensation Reaction ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Human Breast ◽  
Nitrogen Ligand ◽  
Pyramidal Geometry ◽  
Square Planar ◽  
Square Pyramidal Geometry ◽  
Mcf 7

Introduction:A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligandi.e.naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction.Methods:The complexes have been characterized by elemental analysis, spectral (IR, UV–Vis, and ESR, molar conductivity, and magnetic as well as thermal analysis measurements.Results:On the basis of above studies, an octahedral geometry has been proposed for all complexes except Cu(II) nitrate complex that adopt square pyramidal geometry, and square planar geometry for Pd(II) chloride complex, respectively.Conclusion:The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. Moreover, thein vitroantitumor activity of the some synthesized complexes against human breast and human hepatocarcinoma cell lines (MCF-7) and (HePG2), respectively has been studied.

Mechanism research on the lupeol treatment on MCF-7 breast cancer cells based on cell metabonomics

2014 ◽  
Vol 32 (3) ◽  
pp. 278
Author(s):  
Dongdong SHI ◽  
Yuanyuan KUANG ◽  
Guiming WANG ◽  
Zhangxiao PENG ◽  
Yan WANG ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mechanism Research ◽  
Mcf 7

Anticancer Potential of Calli Versus Seedling Extracts Derived from Rosmarinus officinalis and Coleus hybridus

2020 ◽  
Vol 21 (14) ◽  
pp. 1528-1538
Author(s):  
Sarah Albogami ◽  
Hadeer Darwish ◽  
Hala M. Abdelmigid ◽  
Saqer Alotaibi ◽  
Ahmed Nour El-Deen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Transcriptional Profiling ◽  
Significant Inhibition ◽  
Rosmarinus Officinalis ◽  
Crude Extracts ◽  
Incidence And Mortality ◽  
Mcf 7

Background: In Saudi Arabia, the incidence and mortality rates of breast cancer are high. Although current treatments are effective, breast cancer cells develop resistance to these treatments. Numerous studies have demonstrated that active compounds in plant extracts, such as the phenolic compound Rosmarinic Acid (RA), exert anti-cancer effects. Objective: We investigated the anticancer properties of methanolic crude extracts of seedlings and calli of Rosmarinus officinalis and Coleus hybridus, two Lamiaceae species. Methods: MCF-7 human breast cancer cells were treated with methanolic crude extracts obtained from plant calli and seedlings generated in vitro, and cell proliferation was evaluated. Transcriptional profiling of the seedling and callus tissues was also conducted. Results: The mRNA expression levels of RA genes were higher in C. hybridus seedlings than in R. officinalis seedlings, as well as in C. hybridus calli than in R. officinalis calli, except for TAT and C4H. In addition, seedling and callus extracts of both R. officinalis and C. hybridus showed anti-proliferative effects against MCF-7 cells after 24 or 48 h of treatment. Discussion: At a low concentration of 10 μg/mL, C. hybridus calli and seedling extracts showed the most significant anti-proliferative effects after 24 and 48 h of exposure (p < 0.01); controls (doxorubicin) also showed significant inhibition, but lesser than that observed with C. hybridus (p < 0.05). Results with R. officinalis callus and seedling extracts did not significantly differ from those with untreated cells. Conclusion: Methanolic extracts of R. officinalis and C. hybridus are potentially valuable options for breast cancer treatment.

A Novel Triazole Derivative Drug Presenting In Vitro and In Vivo Anticancer Properties

2018 ◽  
Vol 18 (17) ◽  
pp. 1483-1493
Author(s):  
Ricardo Imbroisi Filho ◽  
Daniel T.G. Gonzaga ◽  
Thainá M. Demaria ◽  
João G.B. Leandro ◽  
Dora C.S. Costa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Hepatic Function ◽  
Anticancer Properties ◽  
Mcf 7

Background: Cancer is a major cause of death worldwide, despite many different drugs available to treat the disease. This high mortality rate is largely due to the complexity of the disease, which results from several genetic and epigenetic changes. Therefore, researchers are constantly searching for novel drugs that can target different and multiple aspects of cancer. Experimental: After a screening, we selected one novel molecule, out of ninety-four triazole derivatives, that strongly affects the viability and proliferation of the human breast cancer cell line MCF-7, with minimal effects on non-cancer cells. The drug, named DAN94, induced a dose-dependent decrease in MCF-7 cells viability, with an IC50 of 3.2 ± 0.2 µM. Additionally, DAN94 interfered with mitochondria metabolism promoting reactive oxygen species production, triggering apoptosis and arresting the cancer cells on G1/G0 phase of cell cycle, inhibiting cell proliferation. These effects are not observed when the drug was tested in the non-cancer cell line MCF10A. Using a mouse model with xenograft tumor implants, the drug preventing tumor growth presented no toxicity for the animal and without altering biochemical markers of hepatic function. Results and Conclusion: The novel drug DAN94 is selective for cancer cells, targeting the mitochondrial metabolism, which culminates in the cancer cell death. In the end, DAN94 has been shown to be a promising drug for controlling breast cancer with minimal undesirable effects.

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