Mixed receptors of AMPA and NMDA emulated using a ‘Polka Dot’-structured two-dimensional conjugated polymer-based artificial synapse

2020 ◽  
Vol 5 (9) ◽  
pp. 1324-1331
Author(s):  
Hong Han ◽  
Feng Ge ◽  
Mingxue Ma ◽  
Haiyang Yu ◽  
Huanhuan Wei ◽  
...  

‘Polka dot’-structured two-dimensional conjugated polymer-based synaptic transistors successfully emulate different receptors on post-synaptic membrane and advanced forms of synaptic plasticity.

2021 ◽  
Author(s):  
XINGYUN Li ◽  
Bin Han ◽  
Yaojie Xu ◽  
Xiao Liu ◽  
Chunhui Zhao ◽  
...  

As an advanced two-dimensional (2D) material with unique properties, black phosphorus (BP) has attracted great attention in a variety of fields. One of the main obstacles for practical application of...


2021 ◽  
Author(s):  
Xiang Wang ◽  
Xin Zhou ◽  
Anyang Cui ◽  
Menghan Deng ◽  
Xionghu Xu ◽  
...  

We demonstrate flexo-photoelectronic effects of both n-type and p-type 2D semiconductors.


2020 ◽  
Vol 59 (24) ◽  
pp. 9403-9407 ◽  
Author(s):  
Chenguang Li ◽  
Yongshuai Wang ◽  
Ye Zou ◽  
Xiaotao Zhang ◽  
Huanli Dong ◽  
...  

2018 ◽  
Vol 6 (28) ◽  
pp. 13644-13651 ◽  
Author(s):  
Qi Xiao ◽  
Fei Wu ◽  
MengMeng Han ◽  
Zhen Li ◽  
LinNa Zhu ◽  
...  

A new squaraine-based 2D conjugated polymer was developed as the donor material in polymer solar cells and dopant-free hole transporting material in inverted perovskite solar cells, reaching efficiencies of 6.35% and 18.29%, respectively.


2020 ◽  
Vol 132 (24) ◽  
pp. 9489-9493 ◽  
Author(s):  
Chenguang Li ◽  
Yongshuai Wang ◽  
Ye Zou ◽  
Xiaotao Zhang ◽  
Huanli Dong ◽  
...  

2000 ◽  
Vol 122 (24) ◽  
pp. 5885-5886 ◽  
Author(s):  
D. Tyler McQuade ◽  
Jinsang Kim ◽  
Timothy M. Swager

2018 ◽  
Vol 6 (31) ◽  
pp. 8405-8410 ◽  
Author(s):  
Furkan H. Isikgor ◽  
Chilla Damodara Reddy ◽  
Mengsha Li ◽  
Hikmet Coskun ◽  
Bichen Li ◽  
...  

2D hybrid perovskites are formed through the self assembly of polyaniline with PbI6 octahedra.


2021 ◽  
Vol 12 ◽  
Author(s):  
Tomohisa Hosokawa ◽  
Pin-Wu Liu

Synaptic plasticity is a cellular mechanism of learning and memory. The synaptic strength can be persistently upregulated or downregulated to update the information sent to the neuronal network and form a memory engram. For its molecular mechanism, the stability of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type glutamate receptor (AMPAR), a glutamatergic ionotropic receptor, on the postsynaptic membrane has been studied for these two decades. Since AMPAR is not saturated on the postsynaptic membrane during a single event of neurotransmitter release, the number and nanoscale localization of AMPAR is critical for regulating the efficacy of synaptic transmission. The observation of AMPAR on the postsynaptic membrane by super-resolution microscopy revealed that AMPAR forms a nanodomain that is defined as a stable segregated cluster on the postsynaptic membrane to increase the efficacy of synaptic transmission. Postsynaptic density (PSD), an intracellular protein condensate underneath the postsynaptic membrane, regulates AMPAR dynamics via the intracellular domain of Stargazin, an auxiliary subunit of AMPAR. Recently, it was reported that PSD is organized by liquid-liquid phase separation (LLPS) to form liquid-like protein condensates. Furthermore, the calcium signal induced by the learning event triggers the persistent formation of sub-compartments of different protein groups inside protein condensates. This explains the formation of nanodomains via synaptic activation. The liquid-like properties of LLPS protein condensates are ideal for the molecular mechanism of synaptic plasticity. In this review, we summarize the recent progress in the properties and regulation of synaptic plasticity, postsynaptic receptors, PSD, and LLPS.


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