scholarly journals Generation of particle assemblies mimicking enzymatic activity by processing of herbal food: the case of rhizoma polygonati and other natural ingredients in traditional Chinese medicine

2021 ◽  
Author(s):  
Enrico Benassi ◽  
Haiyan Fan ◽  
Qinglei Sun ◽  
Kanat Dukenbayev ◽  
Qian Wang ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Enzymatic Activity ◽  
Nanoparticle Assemblies ◽  
Particle Assemblies

Processing of rhizoma polygonati-tai (huangjing-tai) or other herbs produces nanoparticle assemblies with enzyme activity, referred to as herbzymes.

scholarly journals Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Huan-Hua Xu ◽  
Fei-Ran Hao ◽  
Mei-Xi Wang ◽  
Si-Jia Ren ◽  
Ming Li ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Dependent Manner ◽  
Dosage Group ◽  
Cytochrome P450 Enzymes ◽  
High Dosage Group ◽  
Chinese Medicine Formula ◽  
Indigo Naturalis ◽  
Dose Dependent

The purpose of this work was to study the influences of Realgar-Indigo naturalis(RIF) and its principal element realgar on 4 main cytochrome P450 enzymes activities in rats. A simple and efficient cocktail method was developed to detect the four probe drugs simultaneously. In this study, Wistar rats were administered intragastric RIF and realgar for 14 days; mixed probe drugs were injected into rats by caudal vein. Through analyzing the pharmacokinetic parameter of mixed probe drugs in rats, we can calculate the CYPs activities. The results showed that RIF could inhibit CYP1A2 enzyme activity and induce CYP2C11 enzyme activity significantly. Interestingly, in realgar high dosage group, CYP3A1/2 enzyme activity was inhibited significantly, and different dosage of realgar manifested a good dose-dependent manner. The RIF results indicated that drug coadministrated with RIF may need to be paid attention in relation to drug-drug interactions (DDIs). Realgar, a toxic traditional Chinese medicine (TCM), does have curative effect on acute promyelocytic leukemia (APL). Its toxicity studies should be focused on. We found that, in realgar high dosage group, CYP3A1/2 enzymes activity was inhibited. This phenomenon may explain its potential toxicity mechanism.

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