scholarly journals Graphene based electrochemical immunosensor for the ultra-sensitive label free detection of Alzheimer’s beta amyloid peptides Aβ(1-42)

2021 ◽  
Author(s):  
Hina Yaqub Abbasi ◽  
Zari Tehrani ◽  
Anitha Devadoss ◽  
Muhammad Ali ◽  
Soraya Moradi-Bachiller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
High Sensitivity ◽  
Beta Amyloid ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Amyloid Peptides ◽  
Label Free Detection ◽  
High Sensitivity Detection ◽  
Sensitivity Detection ◽  
Screen Printed

An immunosensor, capable of high sensitivity detection of beta-amyloid peptides, shown to be a reliable biomarker for Alzheimer’s disease, has been developed using screen printed graphene electrodes (SPGEs) modified with...

A carbon ink screen-printed immunoelectrode for Dengue virus NS1protein detection based on photosynthesized amine gold nanoparticles

2018 ◽  
pp. 1-12
Keyword(s):  
Gold Nanoparticles ◽  
Dengue Virus ◽  
Limit Of Detection ◽  
Colloidal Suspension ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Vis Spectroscopy ◽  
Label Free Detection ◽  
The Impact ◽  
Screen Printed

Dengue virus (DENV) is a reemerging mosquito-borne disease that is endemic in more than 125 countries, affecting 200 million people per year. Screening testing has been a good attempt to minimize the impact caused by high morbity and mortality rates of DENV. In this study, a simple and disposable label-free electrochemical immunosensor based on a carbon ink graphite screen-printed electrode (SPE) one-step fabricated was developed for detection of non-structural 1 protein (NS1). The SPE surface was modified by drop casting, depositing a colloidal suspension containing amine-functionalized gold nanoparticles (AuNP-NH2). AuNPs were synthetized by a photoinduced physical method, illuminating preformed gold seeds with a light-emitting diode (LED,) at blue region, by using the polyethyleneimine (NH2) as reductor and stabilizing agent. UV-VIS spectroscopy and Transmission Electron Microscopy (TEM) were used to characterize the amine AuNPs. Electrocatalytic activity of AuNPs allowed more sensitivity for a label-free detection of NS1 by square wave voltammetry (SWV), with linear response from 0.1 to 2 µg mL-1. It was found a good linearity (coefficient of correlation of 0.995 (p<0.01) and a limit of detection of 0.03 µg mL-1 NS1 for analytical responses. AuNP-NH2 synthesis provided an easy oriented immobilization of anti-NS1 antibodies by Fc portion, resulting in a simple fabrication immunosensor with relative high performance and feasibility for early diagnostic of DENV.

A label-free electrochemical immunosensor for beta-amyloid detection

2016 ◽  
Vol 8 (31) ◽  
pp. 6115-6120 ◽  
Author(s):  
Ajeet Kaushik ◽  
Pratikkumar Shah ◽  
Phani Kiran Vabbina ◽  
Rahul Dev Jayant ◽  
Sneham Tiwari ◽  
...  
Keyword(s):  
Beta Amyloid ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Self Assembled Monolayer ◽  
Interdigitated Electrode ◽  
Label Free Detection ◽  
Self Assembled

A label-free detection of beta-amyloid (βA) proteins using an electrochemical immunosensor fabricated via immobilizing specific anti-beta-amyloid antibodies (An-βA-Abs) onto an interdigitated electrode of gold (IDE-Au) modified using a self-assembled monolayer (SAM) of dithiobis(succinimidyl propionate) [DTSP] is presented here.

Label-free detection of β-amyloid peptides (Aβ40 and Aβ42): a colorimetric sensor array for plasma monitoring of Alzheimer's disease

Nanoscale ◽  
2018 ◽  
Vol 10 (14) ◽  
pp. 6361-6368 ◽  
Author(s):  
Forough Ghasemi ◽  
M. Reza Hormozi-Nezhad ◽  
Morteza Mahmoudi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sensor Array ◽  
Colorimetric Sensor ◽  
Label Free ◽  
Aβ Peptides ◽  
Amyloid Peptides ◽  
Colorimetric Sensor Array ◽  
Label Free Detection ◽  
Β Amyloid

A nanoparticle-based colorimetric sensor array for identification of structurally similar Aβ peptides (Aβ40 and Aβ42) for monitoring of Alzheimer's disease at early stages.

scholarly journals High-sensitivity detection of TNT

2006 ◽  
Vol 103 (52) ◽  
pp. 19630-19634 ◽  
Author(s):  
M. B. Pushkarsky ◽  
I. G. Dunayevskiy ◽  
M. Prasanna ◽  
A. G. Tsekoun ◽  
R. Go ◽  
...  
Keyword(s):  
High Sensitivity ◽  
High Sensitivity Detection ◽  
Sensitivity Detection

scholarly journals Photostable phosphorescent polymer nanospheres for high sensitivity detection

2015 ◽  
Vol 3 (25) ◽  
pp. 6565-6572 ◽  
Author(s):  
A. N. Edwards ◽  
M. Yamazaki ◽  
S. H. Krishnadasan ◽  
T. W. Phillips ◽  
L. Rowlands ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Simple Method ◽  
Polymer Nanospheres ◽  
High Sensitivity Detection ◽  
Sensitivity Detection

A simple method is presented for the preparation of photostable phosphorescent polymer nanospheres.

Simple and high-sensitivity detection of dioxin using dioxin-binding pentapeptide

2007 ◽  
Vol 22 (9-10) ◽  
pp. 2093-2099 ◽  
Author(s):  
Yasuhiro Inuyama ◽  
Chikashi Nakamura ◽  
Tomohiro Oka ◽  
Yasuhiro Yoneda ◽  
Ikuo Obataya ◽  
...  
Keyword(s):  
High Sensitivity ◽  
High Sensitivity Detection ◽  
Sensitivity Detection
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