scholarly journals Quenching of nonlinear photoacoustic signal generation in gold nanoparticles through coating

2020 ◽  
Vol 2 (7) ◽  
pp. 2699-2704
Author(s):  
Genny A. Pang ◽  
Christoph Haisch ◽  
Jan Laufer
Keyword(s):  
Gold Nanoparticles ◽  
Photoacoustic Signal ◽  
Signal Generation ◽  
Gold Nanospheres ◽  
Particle Coating ◽  
Biochemical Sensing

The nonlinear photoacoustic signal behavior from gold nanospheres is suppressed through particle coating, which can be used for biochemical sensing.

scholarly journals Exploiting Nonlinear Photoacoustic Signal Generation in Gold Nanospheres for Selective Detection in Serial 3D PA Tomography

2018 ◽  
Vol 4 (12) ◽  
pp. 146 ◽  
Author(s):  
Susanne Schrof ◽  
Genny Pang ◽  
Jens Buchmann ◽  
Jan Laufer
Keyword(s):  
Gold Nanoparticles ◽  
Spatial Distribution ◽  
Signal Amplitude ◽  
Photoacoustic Signal ◽  
Selective Detection ◽  
Gold Nanospheres ◽  
Robust Detection ◽  
Tissue Phantom ◽  
Gold Nanosphere ◽  
Background Contrast

The photoacoustic (PA) signal amplitude measured in gold nanosphere suspensions has been shown to increase nonlinearly with the incident excitation fluence. In this work, this effect is exploited to recover the spatial distribution of gold nanoparticles in tomographic 3D photoacoustic (PA) images against the background contrast provided by absorbers that exhibit a linear relationship between the PA signal amplitude and the fluence. Serial tomographic PA images of a tissue phantom containing gold nanospheres and a tissue-mimicking absorber were acquired. By assessing the linearity of the PA intensity voxel by voxel, the spatial distribution of the gold nanosphere suspension was recovered. The method is shown to enable the robust detection of gold nanoparticles.

An Improved Theory of Photoacoustic Signal Generation in Gases and Liquids

1991 ◽  
pp. 511-515
Author(s):  
András Miklós ◽  
Zoltán Bozóki ◽  
András Lőrincz
Keyword(s):  
Photoacoustic Signal ◽  
Signal Generation

Photoacoustic signal generation in leaves: are O2-consuming processes involved?

1992 ◽  
Vol 1098 (2) ◽  
pp. 261-265 ◽  
Author(s):  
Marc Charland ◽  
Konka Veeranjaneyulu ◽  
Denis Charlebois ◽  
Roger M. Leblanc
Keyword(s):  
Photoacoustic Signal ◽  
Signal Generation

scholarly journals Arsenate reductase from Thermus thermophilus conjugated to polyethylene glycol-stabilized gold nanospheres allow trace sensing and speciation of arsenic ions

2016 ◽  
Vol 13 (123) ◽  
pp. 20160629 ◽  
Author(s):  
Jane Politi ◽  
Jolanda Spadavecchia ◽  
Gabriella Fiorentino ◽  
Immacolata Antonucci ◽  
Luca De Stefano
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Environmental Problem ◽  
Thermus Thermophilus ◽  
Arsenate Reductase ◽  
Gold Nanospheres ◽  
Enzyme Adsorption ◽  
Ph Values ◽  
Vis Spectroscopy ◽  
The World

Water sources pollution by arsenic ions is a serious environmental problem all around the world. Arsenate reductase enzyme ( TtArsC ) from Thermus thermophilus extremophile bacterium, naturally binds arsenic ions, As(V) and As (III), in aqueous solutions. In this research, TtArsC enzyme adsorption onto hybrid polyethylene glycol-stabilized gold nanoparticles (AuNPs) was studied at different pH values as an innovative nanobiosystem for metal concentration monitoring. Characterizations were performed by UV/Vis and circular dichroism spectroscopies, TEM images and in terms of surface charge changes. The molecular interaction between arsenic ions and the TtArsC -AuNPs nanobiosystem was also monitored at all pH values considered by UV/Vis spectroscopy. Tests performed revealed high sensitivities and limits of detection equal to 10 ± 3 M −12 and 7.7 ± 0.3 M −12 for As(III) and As(V), respectively.

Delivery and cytotoxicity of doxorubicin and temozolomide to primary glioblastoma cells using gold nanospheres and gold nanorods

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Jyoti Verma ◽  
Henk A. Van Veen ◽  
Sumit Lal ◽  
Cornelis J.F. Van Noorden
Keyword(s):  
Gold Nanoparticles ◽  
Cell Cultures ◽  
Gold Nanorods ◽  
Silica Coating ◽  
Glioblastoma Cell ◽  
Glioblastoma Cells ◽  
Gold Nanospheres ◽  
Primary Glioblastoma ◽  
Direct Delivery

AbstractNanoparticles with coating entrapping a chemotherapeutic drug for delivery have not been tested for their cytotoxic effects in in-vitro glioblastoma cell cultures to increase treatment efficacy. Therefore, we synthesized silica-coated gold nanorods and gold nanospheres that were loaded with doxorubicin or temozolomide. The morphology of the nanoparticles was characterized using transmission electron microscopy (TEM), the molecular structure was characterized using infrared spectroscopy and in vitro efficacy was determined using glioblastoma cell cultures. TEM analysis showed that gold nanorods had a length of 49–65 nm and a diameter of 8.5–14 nm whereas gold nanospheres had a diameter of 9.5–37 nm. Infrared spectroscopy of doxorubicin and temozolomide and the silica coating revealed molecular fingerprints such as bending, stretching and vibrations of chemical bonds that confirmed the presence of silica coating and drug loading of the gold nanoparticles. In the biological assessment of the effects of drug-loaded gold nanoparticles on primary glioblastoma cell cultures, cytotoxicity, viability and the ratio of cyototoxicity and viability were used as parameters to analyze the effects on the cells of drug delivery via gold nanoparticles on the cells. Our data suggest that doxorubicin in the concentration range of 0.12–3.16 μM when delivered using both gold nanorods and nanospheres induced a 3.8–5.5-fold increased cytotoxicity in comparison to direct delivery. Temozolomide in the concentration range of 4.6–115 μM when delivered by either type of gold nanoparticles induced a 2–4-fold increased cytotoxicity in comparison to direct delivery. Nanospheres were more effective in delivery and cytotoxicity of doxorubicin and temozolomide to glioblastoma cells than gold nanorods. Our data suggest that gold nanoparticles and in particular gold nanospheres are more effective in delivery of doxorubicin and temozolomide to primary glioblastoma cells in culture than direct delivery.

Gold nanospheres and nanorods for anti-cancer therapy: comparative studies of fabrication, surface-decoration, and anti-cancer treatments

Nanoscale ◽  
2020 ◽  
Vol 12 (28) ◽  
pp. 14996-15020
Author(s):  
Wei Mao ◽  
Young Ju Son ◽  
Hyuk Sang Yoo
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Gold Nanospheres ◽  
Cancer Treatments ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Irradiation Therapy ◽  
Surface Decoration

Various gold nanoparticles have been explored as cancer therapeutics because they can be widely engineered for use as efficient drug carriers and diagnostic agents, and in photo-irradiation therapy.

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