scholarly journals Porphyromonas gingivalis: where do we stand in our battle against this oral pathogen?

2021 ◽  
Author(s):  
Kaitlind C. Howard ◽  
Octavio A. Gonzalez ◽  
Sylvie Garneau-Tsodikova
Keyword(s):  
Porphyromonas Gingivalis ◽  
Antibacterial Therapy ◽  
Antibacterial Agents ◽  
Oral Pathogen ◽  
Systemic Antibacterial

Local and/or systemic antibacterial therapy has been extensively studied and suggested to control periodontopathogens like P. gingivalis. However, more effective and specific antibacterial agents against oral pathobionts remain to be developed.

scholarly journals Th1 biased response to a novel Porphyromonas gingivalis protein aggravates bone resorption caused by this oral pathogen

2008 ◽  
Vol 10 (6) ◽  
pp. 664-672 ◽  
Author(s):  
Onir Leshem ◽  
Suely S. Kashino ◽  
Reginaldo B. Gonçalves ◽  
Noriyuki Suzuki ◽  
Masao Onodera ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Porphyromonas Gingivalis ◽  
Oral Pathogen

scholarly journals Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis

FEBS Journal ◽  
2020 ◽  
Author(s):  
Cher Farrugia ◽  
Graham P. Stafford ◽  
Jan Potempa ◽  
Robert N. Wilkinson ◽  
Yan Chen ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Vascular Damage ◽  
Oral Pathogen ◽  
Systemic Dissemination

Tobacco tars promote the growth of Porphyromonas gingivalis an anaerobic oral pathogen

Bone ◽  
1995 ◽  
Vol 16 (3) ◽  
pp. 402
Author(s):  
M. Al-Bahrani ◽  
J. Fletcher ◽  
M. Wilson ◽  
M. Harris ◽  
S.J. Hodges
Keyword(s):  
Porphyromonas Gingivalis ◽  
Oral Pathogen

scholarly journals Topical and Systemic Antibacterial Agents in the Treatment of Burns

1970 ◽  
Vol 172 (3) ◽  
pp. 370-384 ◽  
Author(s):  
ROBERT P. HUMMEL ◽  
BRUCE G. MACMILLAN ◽  
WILLIAM A. ALTEMETER
Keyword(s):  
Antibacterial Agents ◽  
Systemic Antibacterial

SYSTEMIC ANTIBACTERIAL THERAPY IN OTOGENOUS AND RHINOGENOUS INTRACRANIAL COMPLICATIONS IN CHILDREN

2017 ◽  
Vol 87 (2) ◽  
pp. 36-40
Author(s):  
A. I. Izvin ◽  
◽  
I. M. Veshkurtseva ◽  
N. E. Kuznetsova ◽  
◽  
...  
Keyword(s):  
Antibacterial Therapy ◽  
Intracranial Complications ◽  
Systemic Antibacterial

Biochemical characterization of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, PgiCA

2013 ◽  
Vol 29 (4) ◽  
pp. 532-537 ◽  
Author(s):  
Sonia Del Prete ◽  
Viviana De Luca ◽  
Daniela Vullo ◽  
Andrea Scozzafava ◽  
Vincenzo Carginale ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Porphyromonas Gingivalis ◽  
Biochemical Characterization ◽  
Oral Pathogen

scholarly journals Conjugal Transfer of Chromosomal DNA Contributes to Genetic Variation in the Oral Pathogen Porphyromonas gingivalis

2007 ◽  
Vol 189 (17) ◽  
pp. 6382-6388 ◽  
Author(s):  
Gena D. Tribble ◽  
Gwyneth J. Lamont ◽  
Ann Progulske-Fox ◽  
Richard J. Lamont
Keyword(s):  
Genetic Variation ◽  
Porphyromonas Gingivalis ◽  
Significant Degree ◽  
Dna Transfer ◽  
Chromosomal Dna ◽  
Adaptation Mechanism ◽  
Oral Pathogen ◽  
Type Iv ◽  
Molecular Events

ABSTRACT Porphyromonas gingivalis is a major oral pathogen that contributes to the development of periodontal disease. There is a significant degree of genetic variation among strains of P. gingivalis, and the population structure has been predicted to be panmictic, indicating that horizontal DNA transfer and recombination between strains are likely. The molecular events underlying this genetic exchange are not understood, although a putative type IV secretion system is present in the genome sequence of strain W83, implying that DNA conjugation may be responsible for genetic transfer in these bacteria. In this study, we provide in vitro evidence for the horizontal transfer of DNA using plasmid- and chromosome-based assays. In the plasmid assays, Bacteroides-derived shuttle vectors were tested for transfer from P. gingivalis strains into Escherichia coli. Of the eight strains tested, five were able to transfer DNA into E. coli by a mechanism most consistent with conjugation. Additionally, strains W83 and 33277 tested positive for the transfer of chromosomally integrated antibiotic resistance markers. Ten chimeras resulting from the chromosomal transfer assay were further analyzed by Southern hybridization and were shown to have exchanged DNA fragments of between 1.1 and 5.6 kb, but the overall strain identity remained intact. Chimeras showed phenotypic changes in the ability to accrete into biofilms, implying that DNA transfer events are sufficient to generate measurable changes in complex behaviors. This ability to transfer chromosomal DNA between strains may be an adaptation mechanism in the complex environment of the host oral cavity.

scholarly journals Nosocomial post-cesarean endometritis: a rationalized strategy of antibacterial therapy

2018 ◽  
Vol 12 (2) ◽  
pp. 12-20
Author(s):  
N. A. Korobkov ◽  
N. N. Volkov ◽  
E. R. Tsoy ◽  
S. М. Mikaelyan
Keyword(s):  
Antibacterial Therapy ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Multidrug Resistant ◽  
E Coli ◽  
Number Of Patients ◽  
Previously Treated ◽  
New Mother ◽  
Clinically Significant ◽  
Klebsiella Spp

The number of patients with nosocomial post-cesarean endometritis is steadily growing. Aim: to study the etiology of nosocomial post-cesarean endometritis and to propose a rationalized antimicrobial therapy. Material and methods. Sixty six puerperas with post-cesarean endometritis were examined. The spectrum of microflora and its resistance to antimicrobial agents were determined using an automatic microbiological analyzer based on mass spectrometry. Results. Enterococci, E. coli, staphylococci and streptococci were the most clinically significant pathogens found in the examined patients with post-cesarean endometritis. The microflora spectrum in the endometrium reflected the previous «antibacterial history»; this association must be taken into account when developing antibacterial therapy. Conclusion. If the new mother was previously treated with antibacterial agents, it is recommended to use a combination of the reserve antibiotics in order to block the entire spectrum of possible multidrug-resistant pathogens. In cases of the resistant Gram-positive microflora (MRSE, MRSA, E. faecium), it is advisable to prescribe vancomycin. For the resistant Gram-negative microflora (Enterobacter spp., Citrobacter spp., E. coli-ESBL+ and Klebsiella spp.-ESBL+), vancomycin should be combined with carbapenems.

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