scholarly journals Fragment-based drug discovery: opportunities for organic synthesis

2021 ◽  
Author(s):  
Jeffrey D. St. Denis ◽  
Richard J. Hall ◽  
Christopher W. Murray ◽  
Tom D. Heightman ◽  
David C. Rees
Keyword(s):  
Organic Chemistry ◽  
Drug Discovery ◽  
Organic Synthesis ◽  
Fragment Based Drug Discovery

Herein is described the concept of fragment sociability and the opportunities for organic chemistry to address the challenges of fragment elaboration.

On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin

MedChemComm ◽  
2013 ◽  
Vol 4 (1) ◽  
pp. 101-111 ◽  
Author(s):  
Vincent Mascitti ◽  
Benjamin A. Thuma ◽  
Aaron C. Smith ◽  
Ralph P. Robinson ◽  
Thomas Brandt ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Drug Discovery ◽  
Organic Synthesis ◽  
Medicinal Chemistry ◽  
Critical Role ◽  
Antidiabetic Agent ◽  
Synthetic Organic Chemistry

The discovery of antidiabetic agent ertugliflozin is described. In this article, emphasis is placed on the critical role that organic synthesis played in influencing our medicinal chemistry strategy.

The molecular diversity of 1,8-diaminonaphthalene in organic chemistry

2020 ◽  
Vol 23 ◽  
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Fatemeh Mohajer ◽  
Suraj N. Mali
Keyword(s):  
Organic Chemistry ◽  
Organic Synthesis ◽  
Molecular Diversity ◽  
Organic Reactions ◽  
Recent Application ◽  
Organic Structure

: 1,8-diaminonaphthalene (1,8-DAN) with special organic structure was applied in organic synthesis to provide efficient complex scaffolds, through the two or four-component fashion. This review highlights its recent application in organic reactions under different conditions and heterogynous catalysts to produce various molecules, which were used as medicines, sensors, and dyes.

Modern Organic Synthesis in the Laboratory

2008 ◽  
Author(s):  
Jie Jack Li ◽  
Chris Limberakis ◽  
Derek A. Pflum
Keyword(s):  
Organic Chemistry ◽  
Graduate Students ◽  
Organic Synthesis ◽  
Functional Group ◽  
Bond Formation ◽  
Reaction Conditions ◽  
Carbon Bond ◽  
Oxidation Reduction ◽  
Carbon Carbon Bond ◽  
Daunting Task

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.

Data augmentation and transfer learning strategies for reaction prediction in low chemical data regimes

2021 ◽  
Author(s):  
Yun Zhang ◽  
Ling Wang ◽  
Xinqiao Wang ◽  
Chengyun Zhang ◽  
Jiamin Ge ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Deep Learning ◽  
Drug Discovery ◽  
Research And Development ◽  
Learning Strategies ◽  
Transfer Learning ◽  
Chemical Reactions ◽  
Data Augmentation ◽  
Learning Method ◽  
Reaction Prediction

An effective and rapid deep learning method to predict chemical reactions contributes to the research and development of organic chemistry and drug discovery.

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