scholarly journals Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 1

2020 ◽  
Vol 11 (12) ◽  
pp. 1366-1378 ◽  
Author(s):  
R. Kirk ◽  
A. Ratcliffe ◽  
G. Noonan ◽  
M. Uosis-Martin ◽  
D. Lyth ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Rational Design ◽  
Fluoroquinolone Resistance ◽  
Topoisomerase Inhibitors ◽  
Design Synthesis

The discovery of novel tricyclic topoisomerase inhibitors (NTTI's) that address fluoroquinolone resistance.

scholarly journals Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2

2020 ◽  
Vol 11 (12) ◽  
pp. 1379-1385
Author(s):  
R. Kirk ◽  
A. Ratcliffe ◽  
G. Noonan ◽  
M. Uosis-Martin ◽  
D. Lyth ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Bacterial Infections ◽  
Rational Design ◽  
Topoisomerase Ii ◽  
Topoisomerase Inhibitors ◽  
Design Synthesis ◽  
Pharmacokinetic Properties ◽  
Spectrum Activity ◽  
Broad Spectrum Activity

We disclose the discovery of REDX07965, a novel tricyclic topoisomerase inhibitor (NTTI) which has broad spectrum activity, favourable in vitro pharmacokinetic properties and selectivity versus human topoisomerase II.

scholarly journals Rational Design, Synthesis, and Evaluation of Tetrahydroxamic Acid Chelators for Stable Complexation of Zirconium(IV)

2014 ◽  
Vol 20 (19) ◽  
pp. 5584-5591 ◽  
Author(s):  
François Guérard ◽  
Yong-Sok Lee ◽  
Martin W. Brechbiel
Keyword(s):  
Rational Design ◽  
Design Synthesis

Rational Design, Synthesis, and DNA Binding Properties of Novel Sequence-Selective Peptidyl Congeners of Ametantrone

ChemMedChem ◽  
2010 ◽  
Vol 5 (7) ◽  
pp. 1080-1091 ◽  
Author(s):  
Alessandra Gianoncelli ◽  
Serena Basili ◽  
Matteo Scalabrin ◽  
Alice Sosic ◽  
Stefano Moro ◽  
...  
Keyword(s):  
Dna Binding ◽  
Rational Design ◽  
Binding Properties ◽  
Design Synthesis ◽  
Dna Binding Properties
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