scholarly journals Elaboration and mechanical properties of elastomeric fibrous scaffolds based on crosslinked poly(glycerol sebacate) and cyclodextrin for soft tissue engineering

2021 ◽  
Author(s):  
Florence Flaig ◽  
Caroline Faria Bellani ◽  
Özgün Uyumaz ◽  
Guy Schlatter ◽  
Anne Hébraud
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Soft Tissue ◽  
Electrospun Scaffolds ◽  
Fibrous Scaffolds ◽  
Soft Tissue Engineering

Poly(glycerol sebacate) (PGS) is a promising materials designed for soft tissue engineering. Several examples of its use to prepare electrospun scaffolds can be found in the literature. However, the fabrication...

scholarly journals Development of Photocrosslinkable Urethane-Doped Polyester Elastomers for Soft Tissue Engineering

2011 ◽  
Vol 1 (1) ◽  
pp. 18-31 ◽  
Author(s):  
Yi Zhang ◽  
Richard T. Tran ◽  
Dipendra Gyawali ◽  
Jian Yang
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Soft Tissue ◽  
Hexamethylene Diisocyanate ◽  
Elongation At Break ◽  
Thermally Induced ◽  
Molar Ratios ◽  
3D Network ◽  
Soft Tissue Engineering

Finding an ideal biomaterial with the proper mechanical properties and biocompatibility has been of intense focus in the field of soft tissue engineering. This paper reports on the synthesis and characterization of a novel crosslinked urethane-doped polyester elastomer (CUPOMC), which was synthesized by reacting a previously developed photocrosslinkable poly (octamethylene maleate citrate) (POMC) prepolymers (pre-POMC) with 1,6-hexamethylene diisocyanate (HDI) followed by thermo- or photo-crosslinking polymerization. The mechanical properties of the CUPOMCs can be tuned by controlling the molar ratios of pre-POMC monomers, and the ratio between the prepolymer and HDI. CUPOMCs can be crosslinked into a 3D network through polycondensation or free radical polymerization reactions. The tensile strength and elongation at break of CUPOMC synthesized under the known conditions range from 0.73±0.12MPa to 10.91±0.64MPa and from 72.91±9.09% to 300.41±21.99% respectively. Preliminary biocompatibility tests demonstrated that CUPOMCs support cell adhesion and proliferation. Unlike the pre-polymers of other crosslinked elastomers, CUPOMC pre-polymers possess great processability demonstrated by scaffold fabrication via a thermally induced phase separation method. The dual crosslinking methods for CUPOMC pre-polymers should enhance the versatile processability of the CUPOMC used in various conditions. Development of CUPOMC should expand the choices of available biodegradable elastomers for various biomedical applications such as soft tissue engineering.

Biodegradable networks for soft tissue engineering by thiol–yne photo cross-linking of multifunctional polyesters

RSC Advances ◽  
2014 ◽  
Vol 4 (60) ◽  
pp. 32017-32023 ◽  
Author(s):  
Adrien Leroy ◽  
Assala Al Samad ◽  
Xavier Garric ◽  
Sylvie Hunger ◽  
Danièle Noël ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Cross Linking ◽  
Soft Tissue Engineering

Degradable and biocompatible networks have been prepared via thiol–yne photochemistry from novel alkyne multifunctional PCL. The mechanical properties of these cross-linked biomaterials could make them good candidates for soft tissues scaffolds.

Electrospun hybrid nanofibrous meshes with adjustable performance for potential use in soft tissue engineering

2021 ◽  
pp. 004051752110639
Author(s):  
Ye Qi ◽  
Huiyuan Zhai ◽  
Yaning Sun ◽  
Hongxing Xu ◽  
Shaohua Wu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Soft Tissue ◽  
Fiber Diameter ◽  
Fiber Morphology ◽  
Surface Hydrophilicity ◽  
Nanofibrous Scaffolds ◽  
Soft Tissue Engineering ◽  
The Mean

Electrospun nanofibrous scaffolds have gained extensive attention in the fields of soft tissue engineering and regenerative medicine. In this study, a series of biodegradable nanofibrous meshes were fabricated by electrospinning poly(ε-caprolactone) (PCL) and poly( p-dioxanone) (PPDO) blends with various mass ratios. All the as-developed PCL/PPDO nanofibrous meshes possessed smooth and highly aligned fiber morphology. The mean fiber diameter was 521.5 ± 76.6 nm for PCL meshes and 485.8 ± 88.9 nm for PPDO meshes, and the mean fiber diameter seemed to present a decreasing tendency with the increasing of the PPDO component. For pure PCL meshes, the contact angle was about 117.5 ± 1.6°, the weight loss ratio was roughly 0.2% after 10 weeks of degradation, and the tensile strength was 41.2 ± 2.3 MPa in the longitudinal direction and 4.2 ± 0.1 MPa in the transverse direction. It was found that the surface hydrophilicity and in vitro degradation properties of PCL/PPDO meshes apparently increased, but the mechanical properties of PCL/PPDO meshes obviously decreased when more PPDO component was introduced. The biological tests showed that 4:1 PCL/PPDO nanofibrous meshes and 1:1 PCL/PPDO nanofibrous meshes could obviously promote the adhesion and proliferation of human adipose derived mesenchymal stem cells more than pure PCL and PPDO meshes and 1:4 PCL/PPDO meshes. The results demonstrated that it is feasible to adjust the surface hydrophilicity, degradation profile, and mechanical properties as well as biological properties of as-obtained nanofibrous meshes by blending PCL and PPDO components. This study provides meaningful reference and guidance for the design and development of PCL/PPDO hybrid nanofibrous scaffolds for soft tissue engineering research and application.

Hyaluronic acid/EDC/NHS-crosslinked green electrospun silk fibroin nanofibrous scaffolds for tissue engineering

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 99720-99728 ◽  
Author(s):  
Xingxing Yang ◽  
Xiaoyun Wang ◽  
Fan Yu ◽  
Linlin Ma ◽  
Xiaohan Pan ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Silk Fibroin ◽  
Nanofibrous Scaffolds ◽  
Soft Tissue Engineering

The mechanical properties of SF nanofibrous matrices were enhanced through crosslinking with HA/EDC/NHS for soft tissue engineering.

scholarly journals High Throughput Manufacturing of Bio-Resorbable Micro-Porous Scaffolds Made of Poly(L-lactide-co-ε-caprolactone) by Micro-Extrusion for Soft Tissue Engineering Applications

Polymers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 34 ◽  
Author(s):  
Xabier Mendibil ◽  
Rocío Ortiz ◽  
Virginia Sáenz de Viteri ◽  
Jone M. Ugartemendia ◽  
Jose-Ramon Sarasua ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Soft Tissue ◽  
High Throughput ◽  
Dimensional Stability ◽  
Soft Tissues ◽  
Porous Scaffolds ◽  
Elastomeric Materials ◽  
Soft Tissue Engineering ◽  
Tunable Mechanical Properties

Porous scaffolds made of elastomeric materials are of great interest for soft tissue engineering. Poly(L-lactide-co-ε-caprolactone) (PLCL) is a bio-resorbable elastomeric copolymer with tailorable properties, which make this material an appropriate candidate to be used as scaffold for vascular, tendon, and nerve healing applications. Here, extrusion was applied to produce porous scaffolds of PLCL, using NaCl particles as a leachable agent. The effects of the particle proportion and size on leaching performance, dimensional stability, mechanical properties, and ageing of the scaffolds were analyzed. The efficiency of the particle leaching and scaffold swelling when wet were observed to be dependent on the porogenerator proportion, while the secant moduli and ultimate tensile strengths were dependent on the pore size. Porosity, swelling, and mechanical properties of the extruded scaffolds were tailorable, varying with the proportion and size of porogenerator particles and showed similar values to human soft tissues like nerves and veins (E = 7–15 MPa, σu = 7 MPa). Up to 300-mm length micro-porous PLCL tube with 400-µm thickness wall was extruded, proving extrusion as a high-throughput manufacturing process to produce tubular elastomeric bio-resorbable porous scaffolds of unrestricted length with tunable mechanical properties.

scholarly journals Poly(Glycerol Sebacate)–Poly(l-Lactide) Nonwovens. Towards Attractive Electrospun Material for Tissue Engineering

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2113 ◽  
Author(s):  
Piotr Denis ◽  
Michał Wrzecionek ◽  
Agnieszka Gadomska-Gajadhur ◽  
Paweł Sajkiewicz
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Lactic Acid ◽  
Soft Tissue ◽  
Electrospinning Process ◽  
Soft Tissue Engineering ◽  
Esterification Degree ◽  
Full Utilization

Two types of poly(glycerol sebacate) (PGS) prepolymers were synthesized and electrospun with poly(l-lactic acid) (PLA), resulting in bicomponent nonwovens. The obtained materials were pre-heated in a vacuum, at different times, to crosslink PGS and investigate morphological and structural dependencies in that polymeric, electrospun system. As both PGS and PLA are sensitive to pre-heating (crosslinking) conditions, research concerns both components. More interest is focused on the properties of PGS, considering further research for mechanical properties and subsequent experiments with PGS synthesis. Electrospinning of PGS blended with PLA does not bring difficulties, but obtaining elastomeric properties of nonwovens is problematic. Even though PGS has many potential advantages over other polyesters when soft tissue engineering is considered, its full utilization via the electrospinning process is much harder in practice. Further investigations are ongoing, especially with the promising PGS prepolymer with a higher esterification degree and its variations.

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