scholarly journals Cold atmospheric plasma cancer treatment, direct versus indirect approaches

2020 ◽  
Vol 1 (6) ◽  
pp. 1494-1505
Author(s):  
Alisa Malyavko ◽  
Dayun Yan ◽  
Qihui Wang ◽  
Andrea L. Klein ◽  
Khyati C. Patel ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cancer Cells ◽  
Cellular Responses ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

This review summarized the unique cellular responses to the direct CAP treatment on cancer cells.

The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

2018 ◽  
Vol 18 (6) ◽  
pp. 769-775 ◽  
Author(s):  
Dayun Yan ◽  
Jonathan H. Sherman ◽  
Michael Keidar
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Current Status ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer ◽  
Long Time ◽  
Key Topics ◽  
The Common

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

scholarly journals The Cell Activation Phenomena in the Cold Atmospheric Plasma Cancer Treatment

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Dayun Yan ◽  
Wenjun Xu ◽  
Xiaoliang Yao ◽  
Li Lin ◽  
Jonathan H. Sherman ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cell Activation ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

Cold atmospheric plasma treatment inhibits growth in colorectal cancer cells

2018 ◽  
Vol 400 (1) ◽  
pp. 111-122 ◽  
Author(s):  
Christin Schneider ◽  
Stephanie Arndt ◽  
Julia L. Zimmermann ◽  
Yangfang Li ◽  
Sigrid Karrer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Plasma Treatment ◽  
Cancer Cells ◽  
Ex Vivo ◽  
Atmospheric Plasma ◽  
Normal Colon ◽  
Colon Tissue ◽  
Cold Atmospheric Plasma ◽  
Colorectal Cancer Cells

AbstractPlasma oncology is a relatively new field of research. Recent developments have indicated that cold atmospheric plasma (CAP) technology is an interesting new therapeutic approach to cancer treatment. In this study, p53 wildtype (LoVo) and human p53 mutated (HT29 and SW480) colorectal cancer cells were treated with the miniFlatPlaSter – a device particularly developed for the treatment of tumor cells – that uses the Surface Micro Discharge (SMD) technology for plasma production in air. The present study analyzed the effects of plasma on colorectal cancer cellsin vitroand on normal colon tissueex vivo. Plasma treatment had strong effects on colon cancer cells, such as inhibition of cell proliferation, induction of cell death and modulation of p21 expression. In contrast, CAP treatment of murine colon tissueex vivofor up to 2 min did not show any toxic effect on normal colon cells compared to H2O2positive control. In summary, these results suggest that the miniFlatPlaSter plasma device is able to kill colorectal cancer cells independent of their p53 mutation status. Thus, this device presents a promising new approach in colon cancer therapy.

scholarly journals Cold Atmospheric Plasma for Selectively Ablating Metastatic Breast Cancer Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73741 ◽  
Author(s):  
Mian Wang ◽  
Benjamin Holmes ◽  
Xiaoqian Cheng ◽  
Wei Zhu ◽  
Michael Keidar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Cold Atmospheric Plasma Induces HMGB1 Expression in Cancer Cells

2019 ◽  
Vol 39 (5) ◽  
pp. 2405-2413 ◽  
Author(s):  
YONGDAE YOON ◽  
BONGHYE KU ◽  
KEUNHO LEE ◽  
YONG JIN JUNG ◽  
SEUNG JOON BAEK
Keyword(s):  
Cancer Cells ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Hmgb1 Expression

scholarly journals Micro-Sized Cold Atmospheric Plasma Source for Brain and Breast Cancer Treatment

2018 ◽  
Vol 8 (2) ◽  
pp. 203-215 ◽  
Author(s):  
Zhitong Chen ◽  
Li Lin ◽  
Qinmin Zheng ◽  
Jonathan H. Sherman ◽  
Jerome Canady ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Plasma Source ◽  
Breast Cancer Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Principles of using Cold Atmospheric Plasma Stimulated Media for Cancer Treatment

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Dayun Yan ◽  
Annie Talbot ◽  
Niki Nourmohammadi ◽  
Xiaoqian Cheng ◽  
Jerome Canady ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Dayun Yan ◽  
Haitao Cui ◽  
Wei Zhu ◽  
Niki Nourmohammadi ◽  
Julian Milberg ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Cold Atmospheric Plasma Selectively Induces G0/G1 Cell Cycle Arrest and Apoptosis in AR-Independent Prostate Cancer Cells

2020 ◽  
Author(s):  
Meng Ning ◽  
Zhifa Zhang ◽  
Lihui Yu ◽  
Peiyu Han ◽  
xiaofeng Dai
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Atmospheric Plasma ◽  
Prostate Cancer Cells ◽  
Cold Atmospheric Plasma ◽  
Prostate Cancers ◽  
And Migration ◽  
Physical Plasma

Abstract BackgroundAndrogen receptor-independent prostate cancers do not respond to androgen blockage therapies and suffer from high recurrence rate. We aim to contribute to the establishment of novel therapeutic approaches against such malignancies.Methods We examined whether and how cold atmospheric plasma delivers selectivity against AR-independent prostate cancers using human normal epithelial prostatic cells PNT1A and AR-negative DU145 prostate cancer cells.ResultsWe show that cold atmospheric plasma could selectively halt cell proliferation and migration in androgen receptor-independent cells as a result of induced cell apoptosis and G0/G1 stage cell cycle arrest, and such outcomes were achieved through modulations on the MAPK and NF-kB pathways in response to physical plasma induced intracellular redox level. ConclusionOur study reports cold atmospheric plasma induced reduction on the proliferation and migration of androgen receptor-independent prostate cancer cells that offers novel therapeutic insights on the treatment of such cancers, and provides the first evidence on physical plasma induced cell cycle G0/G1 stage arrest that warrants the exploration on the synergistic use of cold atmospheric plasma and drugs such as chemotherapies in eradicating such cancer cells.

Sign in / Sign up

Export Citation Format

Share Document