Organ-on-a-chip systems: translating concept into practice

Lab on a Chip ◽  
2020 ◽  
Vol 20 (17) ◽  
pp. 3072-3073
Author(s):  
Michael L. Shuler
Keyword(s):  
Lab On A Chip ◽  
Thought Leader ◽  
Organ On A Chip

Thought leader Michael Shuler provides an update on the Lab on a Chip thematic collection organ-on-a-chip systems: translating concept into practice.

Advances in organ-, body-, and disease-on-a-chip systems

Lab on a Chip ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 9-10 ◽  
Author(s):  
Michael L. Shuler
Keyword(s):  
Lab On A Chip ◽  
Thought Leader

Thought leader Michael Shuler provides an update on the Lab on a Chip organ-, body- and disease- on-a-chip thematic collection.

scholarly journals A cost-effective micromilling platform for rapid prototyping of microdevices

TECHNOLOGY ◽  
2016 ◽  
Vol 04 (04) ◽  
pp. 234-239 ◽  
Author(s):  
Daniel P. Yen ◽  
Yuta Ando ◽  
Keyue Shen
Keyword(s):  
Rapid Prototyping ◽  
Low Cost ◽  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Cost Effective ◽  
Multi Scale ◽  
Organ On A Chip

Micromilling has great potential in producing microdevices for lab-on-a-chip and organ-on-a-chip applications, but has remained under-utilized due to the high machinery costs and limited accessibility. In this paper, we assessed the machining capabilities of a low-cost 3-D mill in polycarbonate material, which were showcased by the production of microfluidic devices. The study demonstrates that this particular mill is well suited for the fabrication of multi-scale microdevices with feature sizes from micrometers to centimeters.

Framing technology challenges associated with improving cancer immunotherapies

Lab on a Chip ◽  
2019 ◽  
Vol 19 (20) ◽  
pp. 3366-3367
Author(s):  
James R. Heath
Keyword(s):  
Lab On A Chip ◽  
Thought Leader ◽  
Cancer Immunotherapies

Thought leader Jim Heath introduces the Lab on a Chip Immunotherapy thematic collection.

Nanotechnology-assisted microfluidic systems: from bench to bedside

Nanomedicine ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. 237-258
Author(s):  
Navid Rabiee ◽  
Sepideh Ahmadi ◽  
Yousef Fatahi ◽  
Mohammad Rabiee ◽  
Mojtaba Bagherzadeh ◽  
...  
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
Medical Applications ◽  
Next Generation ◽  
Wide Spread ◽  
Microfluidic Systems ◽  
Collective Attention ◽  
Increased Sensitivity ◽  
Organ On A Chip ◽  
Global Population

With significant advancements in research technologies, and an increasing global population, microfluidic and nanofluidic systems (such as point-of-care, lab-on-a-chip, organ-on-a-chip, etc) have started to revolutionize medicine. Devices that combine micron and nanotechnologies have increased sensitivity, precision and versatility for numerous medical applications. However, while there has been extensive research on microfluidic and nanofluidic systems, very few have experienced wide-spread commercialization which is puzzling and deserves our collective attention. For the above reasons, in this article, we review research advances that combine micro and nanotechnologies to create the next generation of nanomaterial-based microfluidic systems, the latest in their commercialization success and failure and highlight the value of these devices both in industry and in the laboratory.

Organ-, body- and disease-on-a-chip systems

Lab on a Chip ◽  
2017 ◽  
Vol 17 (14) ◽  
pp. 2345-2346 ◽  
Author(s):  
Michael L. Shuler
Keyword(s):  
Lab On A Chip ◽  
Thought Leader

Thought leader Michael Shuler introduces the Lab on a Chip organ, body and disease on a chip thematic collection.

scholarly journals Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip

Micromachines ◽  
2020 ◽  
Vol 11 (6) ◽  
pp. 599 ◽  
Author(s):  
Neda Azizipour ◽  
Rahi Avazpour ◽  
Derek H. Rosenzweig ◽  
Mohamad Sawan ◽  
Abdellah Ajji
Keyword(s):  
Disease Modeling ◽  
Biomedical Application ◽  
Lab On A Chip ◽  
In Vitro Models ◽  
Future Perspectives ◽  
Versatile Tool ◽  
Organ On A Chip ◽  
Review Current

Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) platforms mimic the in vivo like microenvironment of living organs and offer more physiologically relevant in vitro models of human organs. Consequently, the concept of OOC has gained great attention from researchers in the field worldwide to offer powerful tools for biomedical researches including disease modeling, drug development, etc. This review highlights the background of biochip development. Herein, we focus on applications of LOC devices as a versatile tool for POC applications. We also review current progress in OOC platforms towards body-on-a-chip, and we provide concluding remarks and future perspectives for OOC platforms for POC applications.

Laser printing-enabled direct creation of cellular heterogeneity in lab-on-a-chip devices

Lab on a Chip ◽  
2019 ◽  
Vol 19 (9) ◽  
pp. 1644-1656 ◽  
Author(s):  
Ruitong Xiong ◽  
Wenxuan Chai ◽  
Yong Huang
Keyword(s):  
Lab On A Chip ◽  
Cellular Heterogeneity ◽  
Laser Printing ◽  
Forward Transfer ◽  
Organ On A Chip

Laser-induced forward transfer for printing of cellular heterogeneity in organ-on-a-chip devices.

Perspective on droplet-based single-cell sequencing

Lab on a Chip ◽  
2017 ◽  
Vol 17 (15) ◽  
pp. 2539-2539 ◽  
Author(s):  
David A. Weitz
Keyword(s):  
Single Cell ◽  
Lab On A Chip ◽  
Single Cell Sequencing ◽  
Thought Leader

Thought leader David Weitz introduces the Lab on a Chip droplet-based single-cell sequencing thematic collection.

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