A novel sample delivery system based on circular motion for in situ serial synchrotron crystallography

Lab on a Chip ◽  
2020 ◽  
Vol 20 (21) ◽  
pp. 3888-3898
Author(s):  
Feng-Zhu Zhao ◽  
Bo Sun ◽  
Li Yu ◽  
Qing-Jie Xiao ◽  
Zhi-Jun Wang ◽  
...  
Keyword(s):  
Delivery System ◽  
Circular Motion ◽  
Delivery Device ◽  
Microfluidic Technology ◽  
Target Sample ◽  
Serial Crystallography ◽  
Rotating Target

A microfluidic rotating-target sample delivery device based on circular motion for in situ serial crystallography is presented, which combines the advantages of circular motion, microfluidic technology and in situ diffraction.

scholarly journals A portable fixed-target sample delivery system for in situ serial crystallography

2020 ◽  
Vol 76 (a1) ◽  
pp. a102-a102
Author(s):  
Aaron Finke ◽  
Gabrielle Illava ◽  
Benjamin Apker ◽  
Richard Jayne ◽  
David Closs ◽  
...  
Keyword(s):  
Delivery System ◽  
Fixed Target ◽  
Target Sample ◽  
Serial Crystallography

First clinical experience with the Multi-LOC multiple stent delivery system for focal stenting in long femoro-popliteal lesions

VASA ◽  
2017 ◽  
Vol 46 (6) ◽  
pp. 452-461 ◽  
Author(s):  
Klaus Amendt ◽  
Ulrich Beschorner ◽  
Matthias Waliszewski ◽  
Martin Sigl ◽  
Ralf Langhoff ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Experience ◽  
Delivery System ◽  
Target Lesion ◽  
Lesion Length ◽  
Elastic Recoil ◽  
Delivery Device ◽  
Clinical Assessments ◽  
Balloon Catheters ◽  
Considerable Length

Abstract. Background: The purpose of this observational study is to report the six-month clinical outcomes with a new multiple stent delivery system in patients with femoro-popliteal lesions. Patients and methods: The LOCOMOTIVE study is an observational multicentre study with a primary endpoint target lesion revascularization (TLR) rate at six months. Femoro-popliteal lesions were prepared with uncoated and/or paclitaxel-coated peripheral balloon catheters. When flow limiting dissections, elastic recoil or recoil due to calcification required stenting, up to six short stents per delivery device, each 13 mm in length, were implanted. Sonographic follow-ups and clinical assessments were scheduled at six months. Results: For this first analysis, a total of 75 patients 72.9 ± 9.2 years of age were enrolled. The majority of the 176 individually treated lesions were in the superficial femoral artery (76.2 %, 134/176) whereas the rate of TASC C/D amounted to 51.1 % (90/176). The total lesion length was 14.5 ± 9.0 cm with reference vessel diameters of 5.6 ± 0.7 mm. Overall 47 ± 18 % of lesion lengths could be saved from stenting. At six months, the patency was 90.7 % (68/75) and all-cause TLR rates were 5.3 % (4/75) in the overall cohort. Conclusions: The first clinical experience at six months suggests that the MSDS strategy was safe and effective to treat femoro-popliteal lesions of considerable length (14.5 ± 9.0 cm). Almost half of the lesion length could be saved from stenting while patency was high and TLR rates were acceptably low.

In vivo evaluation of risperidone-SAIB in situ system as a sustained release delivery system in rats

2008 ◽  
Vol 68 (2) ◽  
pp. 422-429 ◽  
Author(s):  
Yaxin Lu ◽  
Xing Tang ◽  
Yue Cui ◽  
Yu Zhang ◽  
Feng Qin ◽  
...  
Keyword(s):  
Sustained Release ◽  
Delivery System ◽  
In Vivo Evaluation

In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

2007 ◽  
Vol 25 (6) ◽  
pp. 1347-1354 ◽  
Author(s):  
Heiko Kranz ◽  
Erol Yilmaz ◽  
Gayle A. Brazeau ◽  
Roland Bodmeier
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Forming

New in-situ synthetized hydrogel composite based on alginate and brushite as a potential pH sensitive drug delivery system

2017 ◽  
Vol 177 ◽  
pp. 324-333 ◽  
Author(s):  
Seyed Mohammad Hossein Dabiri ◽  
Alberto Lagazzo ◽  
Fabrizio Barberis ◽  
Amirreza Shayganpour ◽  
Elisabetta Finocchio ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Hydrogel Composite

scholarly journals In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

2020 ◽  
Vol 10 (5-s) ◽  
pp. 32-39
Author(s):  
Fatima Eram ◽  
, Vivek
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Average Concentration ◽  
Posterior Segment ◽  
Ocular Infection ◽  
In Vivo Evaluation ◽  
Micro Emulsion ◽  
In Situ Gelling

Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e.  >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis. Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

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