A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes

Lab on a Chip ◽  
2020 ◽  
Vol 20 (11) ◽  
pp. 1898-1906
Author(s):  
Jaime L. Korner ◽  
Elanna B. Stephenson ◽  
Katherine S. Elvira
Keyword(s):  
Intestinal Absorption ◽  
Drug Absorption ◽  
Cell Membranes ◽  
State Of The Art ◽  
Compartment Model ◽  
Current State ◽  
Artificial Cell ◽  
New Type

A new type of pharmacokinetic compartment model using artificial cell membranes that predicts intestinal absorption three times more accurately than the current state of the art.

scholarly journals Correction: A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes

Lab on a Chip ◽  
2020 ◽  
Vol 20 (17) ◽  
pp. 3279-3279
Author(s):  
Jaime L. Korner ◽  
Elanna B. Stephenson ◽  
Katherine S. Elvira
Keyword(s):  
Drug Absorption ◽  
Cell Membranes ◽  
Compartment Model ◽  
Artificial Cell

Correction for ‘A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes’ by Jaime L. Korner et al., Lab Chip, 2020, 20, 1898–1906, DOI: 10.1039/D0LC00263A.

Modeling and Study of the Quasi-Static Behavior of Piezoceramic Telescopic Actuation Architectures

1999 ◽  
Author(s):  
Neal T. Berner ◽  
Diann E. Brei
Keyword(s):  
State Of The Art ◽  
Piezoelectric Actuation ◽  
Static Behavior ◽  
Main Design ◽  
Current State ◽  
End Caps ◽  
New Type ◽  
Piezoelectric Strain ◽  
Piezoelectric Stacks

Abstract Piezoelectric stacks are often used in smart structures applications that demand high forces. However, there are numerous applications that require slightly more displacement than is available from stacks and the requirements allow room for some force to be sacrificed to obtain the displacement. A new type of piezoelectric actuation architecture, referred to as telescopic, was designed to meet the need for moderate displacement amplification (one to 20 times) while still producing large forces. This architecture internally leverages the piezoelectric strain by a series of cascading cylinders uniquely connected by end caps such that they “telescope” out when activated. This paper presents an analytical model to predict the force-deflection behavior of this actuator with compliant end caps. The compliance in the end caps governs the quality of the performance and is one of the main design drivers. To aid in evaluating this new architecture, the effect of other architectural losses, such as gap size and number of cylinders, is presented along with a comparison to the current state of the art.

ESEM - A multipurpose surface Electron Microscope

1986 ◽  
Vol 44 ◽  
pp. 632-633 ◽  
Author(s):  
G.D. Danilatos
Keyword(s):  
Electron Microscope ◽  
Room Temperature ◽  
Environmental Scanning ◽  
Gas Composition ◽  
Saturated Water Vapor ◽  
Surface Electron ◽  
Current State ◽  
Saturated Water ◽  
New Type ◽  
Temperature And Pressure

Over recent years a new type of electron microscope - the environmental scanning electron microscope (ESEM) - has been developed for the examination of specimen surfaces in the presence of gases. A detailed series of reports on the system has appeared elsewhere. A review summary of the current state and potential of the system is presented here.The gas composition, temperature and pressure can be varied in the specimen chamber of the ESEM. With air, the pressure can be up to one atmosphere (about 1000 mbar). Environments with fully saturated water vapor only at room temperature (20-30 mbar) can be easily maintained whilst liquid water or other solutions, together with uncoated specimens, can be imaged routinely during various applications.

Behavioral Genetics: Concepts for Research and Practice in Language Development and Disorders

1995 ◽  
Vol 38 (5) ◽  
pp. 1126-1142 ◽  
Author(s):  
Jeffrey W. Gilger
Keyword(s):  
Language Development ◽  
Behavioral Genetics ◽  
State Of The Art ◽  
Genetic Research ◽  
Great Promise ◽  
Behavioral Genetic ◽  
Fine Grained ◽  
Future Goals ◽  
Current State ◽  
Research Designs

This paper is an introduction to behavioral genetics for researchers and practioners in language development and disorders. The specific aims are to illustrate some essential concepts and to show how behavioral genetic research can be applied to the language sciences. Past genetic research on language-related traits has tended to focus on simple etiology (i.e., the heritability or familiality of language skills). The current state of the art, however, suggests that great promise lies in addressing more complex questions through behavioral genetic paradigms. In terms of future goals it is suggested that: (a) more behavioral genetic work of all types should be done—including replications and expansions of preliminary studies already in print; (b) work should focus on fine-grained, theory-based phenotypes with research designs that can address complex questions in language development; and (c) work in this area should utilize a variety of samples and methods (e.g., twin and family samples, heritability and segregation analyses, linkage and association tests, etc.).

Schizophrenia Research: Current State of the Art

1976 ◽  
Vol 21 (7) ◽  
pp. 497-498
Author(s):  
STANLEY GRAND
Keyword(s):  
State Of The Art ◽  
Current State

Umbral Calculus

10.37236/24 ◽  
2002 ◽  
Vol 1000 ◽  
Author(s):  
A. Di Bucchianico ◽  
D. Loeb
Keyword(s):  
19Th Century ◽  
Finite Differences ◽  
State Of The Art ◽  
Umbral Calculus ◽  
Current State ◽  
Logical Foundation ◽  
Complete Bibliography ◽  
The 19Th Century ◽  
Mathematical Literature

We survey the mathematical literature on umbral calculus (otherwise known as the calculus of finite differences) from its roots in the 19th century (and earlier) as a set of “magic rules” for lowering and raising indices, through its rebirth in the 1970’s as Rota’s school set it on a firm logical foundation using operator methods, to the current state of the art with numerous generalizations and applications. The survey itself is complemented by a fairly complete bibliography (over 500 references) which we expect to update regularly.

The Receptor-Dependent QSAR Paradigm: An Overview of the Current State of the Art

2009 ◽  
Vol 5 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Osvaldo Santos-Filho ◽  
Anton Hopfinger ◽  
Artem Cherkasov ◽  
Ricardo de Alencastro
Keyword(s):  
State Of The Art ◽  
Current State

scholarly journals Smoothing additive manufactured parts using ns-pulsed laser radiation

2021 ◽  
Author(s):  
Florian Kuisat ◽  
Fernando Lasagni ◽  
Andrés Fabián Lasagni
Keyword(s):  
Surface Roughness ◽  
Mechanical Performance ◽  
State Of The Art ◽  
Pulsed Laser ◽  
Industrial Applications ◽  
Laser Source ◽  
Pulsed Laser Radiation ◽  
Current State ◽  
The Impact

AbstractIt is well known that the surface topography of a part can affect its mechanical performance, which is typical in additive manufacturing. In this context, we report about the surface modification of additive manufactured components made of Titanium 64 (Ti64) and Scalmalloy®, using a pulsed laser, with the aim of reducing their surface roughness. In our experiments, a nanosecond-pulsed infrared laser source with variable pulse durations between 8 and 200 ns was applied. The impact of varying a large number of parameters on the surface quality of the smoothed areas was investigated. The results demonstrated a reduction of surface roughness Sa by more than 80% for Titanium 64 and by 65% for Scalmalloy® samples. This allows to extend the applicability of additive manufactured components beyond the current state of the art and break new ground for the application in various industrial applications such as in aerospace.

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