Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines

2021 ◽  
Author(s):  
Melissa C. D'Amaral ◽  
Nick Jamkhou ◽  
Marc J. Adler
Keyword(s):  
Carboxylic Acids ◽  
Practical Method ◽  
Direct Coupling ◽  
Amide Coupling

A highly practical method for the direct coupling of amines and unactivated carboxylic acids to form amides.

Water-Removable Ynamide Coupling Reagent for Racemization-Free Syntheses of Peptides, Amides, and Esters

2021 ◽  
Author(s):  
Tao Liu ◽  
Xue Zhang ◽  
Zejun Peng ◽  
Junfeng Zhao
Keyword(s):  
Carboxylic Acids ◽  
Direct Coupling ◽  
Coupling Reagent

A novel ynamide coupling reagent, the by-product of which can be removed by water, was reported. It promotes the direct coupling between carboxylic acids and amines, alcohols or thiols to...

Substrate selective amide coupling driven by encapsulation of a coupling agent within a self-assembled hexameric capsule

2015 ◽  
Vol 51 (9) ◽  
pp. 1658-1661 ◽  
Author(s):  
Sonia Giust ◽  
Giorgio La Sorella ◽  
Laura Sperni ◽  
Giorgio Strukul ◽  
Alessandro Scarso
Keyword(s):  
Carboxylic Acids ◽  
Coupling Agent ◽  
Primary Amines ◽  
Substrate Selectivity ◽  
Synthesis Reaction ◽  
Amide Synthesis ◽  
Amide Coupling ◽  
Self Assembled

Encapsulation of a cationic carbodiimide condensing agent within a self-assembled hexameric capsule made of resorcin[4]arene units provides a nano-environment that efficiently steers the substrate selectivity in the amide synthesis reaction between carboxylic acids and primary amines.

Diphenylsilane as a coupling reagent for amide bond formation

2017 ◽  
Vol 19 (21) ◽  
pp. 5060-5064 ◽  
Author(s):  
Morgane Sayes ◽  
André B. Charette
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Direct Coupling ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Coupling Reagent

A simple amidation procedure enabling the direct coupling of carboxylic acids to amines using one equivalent of diphenysilane is reported.

scholarly journals Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of (Hetero)arenes Using Trifluoroacetic and Related Carboxylic Acids

2020 ◽  
Author(s):  
Dehang Yin ◽  
Dengquan Su ◽  
Jian Jin
Keyword(s):  
Carboxylic Acids ◽  
Trifluoroacetic Acid ◽  
Practical Method ◽  
Photoredox Catalysis ◽  
Mild Conditions

A mild and practical method has been achieved that allows for the direct C–H trifluoromethylation, perfuoroalkylation and chlorodifluoromethylation of (hetero)arenes using inexpensive and abundant trifluoroacetic acid and the corresponding carboxylic acids. A diverse array of arenes and heteroarenes were successfully transformed into valuable fluoroalkylated compounds. The combination of photoredox catalysis and a diaryl sulfoxide provides a platform for the facile generation of fluoroalkyl radicals from the corresponding fluoroalkyl carboxylic acids under mild conditions.

scholarly journals Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of (Hetero)arenes Using Trifluoroacetic and Related Carboxylic Acids

2020 ◽  
Author(s):  
Dehang Yin ◽  
Dengquan Su ◽  
Jian Jin
Keyword(s):  
Carboxylic Acids ◽  
Trifluoroacetic Acid ◽  
Practical Method ◽  
Photoredox Catalysis ◽  
Mild Conditions

A mild and practical method has been achieved that allows for the direct C–H trifluoromethylation, perfuoroalkylation and chlorodifluoromethylation of (hetero)arenes using inexpensive and abundant trifluoroacetic acid and the corresponding carboxylic acids. A diverse array of arenes and heteroarenes were successfully transformed into valuable fluoroalkylated compounds. The combination of photoredox catalysis and a diaryl sulfoxide provides a platform for the facile generation of fluoroalkyl radicals from the corresponding fluoroalkyl carboxylic acids under mild conditions.

Catalyst-free formation of 1,4-diketones by addition of silyl enolates to oxyallyl zwitterions in situ generated from α-haloketones

RSC Advances ◽  
2015 ◽  
Vol 5 (83) ◽  
pp. 67901-67908 ◽  
Author(s):  
Juan Luo ◽  
Qihua Jiang ◽  
Hao Chen ◽  
Qiang Tang
Keyword(s):  
Room Temperature ◽  
Practical Method ◽  
Direct Coupling ◽  
Catalyst Free

Here we report an efficient and practical method for the preparation of 1,4-diketones by direct coupling of α-haloketones with silyl enolates at room temperature. No catalysts were required in our protocol.

Direct Amide Coupling of Non-activated Carboxylic Acids and Amines Catalysed by Zirconium(IV) Chloride

2012 ◽  
Vol 18 (13) ◽  
pp. 3822-3826 ◽  
Author(s):  
Helena Lundberg ◽  
Fredrik Tinnis ◽  
Hans Adolfsson
Keyword(s):  
Carboxylic Acids ◽  
Amide Coupling

scholarly journals A Highly Selective Decarboxylative Deuteration of Carboxylic Acids

2021 ◽  
Author(s):  
Jin Xie ◽  
Nian Li ◽  
Yun-Yun Ning ◽  
Xiaopeng Wu ◽  
Weipeng Li ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Practical Method ◽  
Aliphatic Carboxylic Acids

In this paper, we report a moderate and practical method for precise deuteration of aliphatic carboxylic acids by synergistic photoredox and HAT catalysis. The reaction delivers excellent D-incorporation (up to...

Sign in / Sign up

Export Citation Format

Share Document