Syntheses of two- and three-dimensional covalent organic frameworks in deep eutectic solvents

2020 ◽  
Vol 22 (21) ◽  
pp. 7537-7542 ◽  
Author(s):  
Jikuan Qiu ◽  
Pengxin Guan ◽  
Yuling Zhao ◽  
Zhiyong Li ◽  
Huiyong Wang ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Deep Eutectic Solvents ◽  
Covalent Organic Frameworks ◽  
Ambient Conditions ◽  
Green Strategy ◽  
2D And 3D ◽  
First Time

For the first time, a mild and green strategy is reported for the efficient syntheses of a series of 2D and 3D COFs using deep eutectic solvents as clean media under ambient conditions.

scholarly journals Transformation Between 2D and 3D Covalent Organic Frameworks via Reversible [2+2] Cycloaddition

2020 ◽  
Author(s):  
Thaksen Jadhav ◽  
Yuan Fang ◽  
Cheng-Hao Liu ◽  
Afshin Dadvand ◽  
Ehsan Hamzehpoor ◽  
...  
Keyword(s):  
Band Structure ◽  
Absorption Edge ◽  
Room Temperature ◽  
Three Dimensional ◽  
Cross Linking ◽  
Two Dimensional ◽  
Covalent Organic Frameworks ◽  
Doping Behavior ◽  
2D Polymers ◽  
2D And 3D

We report the first transformation between crystalline vinylene-linked two-dimensional (2D) polymers and crystalline cyclobutane-linked three-dimensional (3D) polymers. Specifically, absorption-edge irradiation of the 2D poly(arylenevinylene) covalent organic frameworks (COFs) results in topological [2+2] cycloaddition cross-linking the π-stacked layers in 3D COFs. The reaction is reversible and heating to 200°C leads to a cycloreversion while retaining the COF crystallinity. The resulting difference in connectivity is manifested in the change of mechanical and electronic properties, including exfoliation, blue-shifted UV-Vis absorption, altered luminescence, modified band structure and different acid-doping behavior. The Li-impregnated 2D and 3D COFs show a significant ion conductivity of 1.8×10<sup>−4</sup> S/cm and 3.5×10<sup>−5</sup> S/cm, respectively. Even higher room temperature proton conductivity of 1.7×10<sup>-2</sup> S/cm and 2.2×10<sup>-3</sup> S/cm was found for H<sub>2</sub>SO<sub>4</sub>-treated 2D and 3D COFs, respectively.

Development of SFEM-Pre: A Novel Preprocessor for Model Creation for the Smoothed Finite Element Method

2019 ◽  
Vol 17 (02) ◽  
pp. 1845002 ◽  
Author(s):  
J. F. Zhang ◽  
R. P. Niu ◽  
Y. F. Zhang ◽  
C. Q. Wang ◽  
M. Li ◽  
...  
Keyword(s):  
Finite Element Method ◽  
Finite Element ◽  
Complex Geometry ◽  
Three Dimensional ◽  
Efficient Computation ◽  
Practical Engineering ◽  
Smoothed Finite Element Method ◽  
2D And 3D ◽  
First Time ◽  
Element Method

Smoothed finite element method (S-FEM) is a new general numerical method which has been applied to solve various practical engineering problems. It combines standard finite element method (FEM) and meshfree techniques based on the weaken-weak (W2) formulation. This project, for the first time, develops a preprocessor software package SFEM-Pre for creating types of two-dimensional (2D) and three-dimensional (3D) S-FEM models following strictly the S-FEM theory. Because the software architecture of our 3D processor is the same as our 2D preprocessor, we will mainly introduce the 2D preprocessor in terms of software design for easier description, but the examples will include both 2D and 3D cases to fully demonstrate and validate the whole preprocessor of S-FEM. Our 2D preprocessor package is equipped with a graphical user interface (GUI) for easy use, and with a connectivity database for efficient computation. Schemes are developed for not only automatically meshes the problem domains using our GUI, but also accepts various geometry files made available from some existing commercial software packages, such as ABAQUS®and HyperMesh®. In order to improve the efficiency of our preprocessor, a parallel triangulation mesh generator has also been developed based on the advancing front technique (AFT) to create triangular meshes for complex geometry, and at the same time to create six types of connectivity needed for various S-FEM models. In addition, a database is implemented in our code to record all these connectivity to avoid duplicated calculation. Finally, intensive numerical experiments are conducted to validate the efficiency, accuracy and stability of our preprocessor codes. It is shown that with our preprocessor, an S-FEM can be created automatically without much human intervention for geometry of arbitrary complexity.

RBF-based mesh morphing approach to perform icing simulations in the aviation sector

2019 ◽  
Vol 91 (4) ◽  
pp. 620-633 ◽  
Author(s):  
Corrado Groth ◽  
Emiliano Costa ◽  
Marco Evangelos Biancolini
Keyword(s):  
High Performance ◽  
Three Dimensional ◽  
Ansys Fluent ◽  
Content Type ◽  
Mesh Morphing ◽  
Computational Fluid Dynamics Cfd ◽  
Cfd Analyses ◽  
2D And 3D ◽  
First Time ◽  
Practical Implications

Purpose Numerical simulation of icing has become a standard. Once the iced shape is known, however, the analyst needs to update the computational fluid dynamics (CFD) grid. This paper aims to propose a method to update the numerical mesh with ice profiles. Design/methodology/approach The present paper concerns a novel and fast radial basis functions (RBF) mesh morphing technique to efficiently and accurately perform ice accretion simulations on industrial models in the aviation sector. This method can be linked to CFD analyses to dynamically reproduce the ice growth. Findings To verify the consistency of the proposed approach, one of the most challenging ice profile selected in the LEWICE manual was replicated and simulated through CFD. To showcase the effectiveness of this technique, predefined ice profiles were automatically applied on two-dimensional (2D) and three-dimensional (3D) cases using both commercial and open-source CFD solvers. Practical implications If ice accreted shapes are available, the meshless characteristic of the proposed approach enables its coupling with the CFD solvers currently supported by the RBF4AERO platform including OpenFOAM, SU2 and ANSYS Fluent. The advantages provided by the use of RBF are the high performance and reliability, due to the fast application of mesh smoothing and the accuracy in controlling surface mesh nodes. Originality/value As far as authors’ knowledge is concerned, this is the first time in scientific literature that RBF are proposed to handle icing simulations. Due to the meshless characteristic of the RBF mesh morphing, the proposed approach is cross solver and can be used for both 2D and 3D geometries.

scholarly journals Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Javier Escudero ◽  
Victoria Heredia-Soto ◽  
Yinyin Wang ◽  
Patricia Ruiz ◽  
Yingying Hu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Cell Line ◽  
Antitumour Activity ◽  
Three Dimensional ◽  
Soft Tissue Sarcomas ◽  
Migration And Invasion ◽  
2D And 3D ◽  
First Time ◽  
Dimensional Cell

Abstract Background Eribulin has shown antitumour activity in some soft tissue sarcomas (STSs), but it has only been approved for advanced liposarcoma (LPS). Methods In this study, we evaluated the effect of eribulin on proliferation, migration and invasion capabilities in LPS, leiomyosarcoma (LMS) and fibrosarcoma (FS) models, using both monolayer (2D) and three-dimensional (3D) spheroid cell cultures. Additionally, we explored combinations of eribulin with other drugs commonly used in the treatment of STS with the aim of increasing its antitumour activity. Results Eribulin showed activity inhibiting proliferation, 2D and 3D migration and invasion in most of the cell line models. Furthermore, we provide data that suggest, for the first time, a synergistic effect with ifosfamide in all models, and with pazopanib in LMS as well as in myxoid and pleomorphic LPS. Conclusions Our results support the effect of eribulin on LPS, LMS and FS cell line models. The combination of eribulin with ifosfamide or pazopanib has shown in vitro synergy, which warrants further clinical research.

scholarly journals Transformation Between 2D and 3D Covalent Organic Frameworks via Reversible [2+2] Cycloaddition

2020 ◽  
Author(s):  
Thaksen Jadhav ◽  
Yuan Fang ◽  
Cheng-Hao Liu ◽  
Afshin Dadvand ◽  
Ehsan Hamzehpoor ◽  
...  
Keyword(s):  
Band Structure ◽  
Absorption Edge ◽  
Room Temperature ◽  
Three Dimensional ◽  
Cross Linking ◽  
Two Dimensional ◽  
Covalent Organic Frameworks ◽  
Doping Behavior ◽  
2D Polymers ◽  
2D And 3D

We report the first transformation between crystalline vinylene-linked two-dimensional (2D) polymers and crystalline cyclobutane-linked three-dimensional (3D) polymers. Specifically, absorption-edge irradiation of the 2D poly(arylenevinylene) covalent organic frameworks (COFs) results in topological [2+2] cycloaddition cross-linking the π-stacked layers in 3D COFs. The reaction is reversible and heating to 200°C leads to a cycloreversion while retaining the COF crystallinity. The resulting difference in connectivity is manifested in the change of mechanical and electronic properties, including exfoliation, blue-shifted UV-Vis absorption, altered luminescence, modified band structure and different acid-doping behavior. The Li-impregnated 2D and 3D COFs show a significant ion conductivity of 1.8×10<sup>−4</sup> S/cm and 3.5×10<sup>−5</sup> S/cm, respectively. Even higher room temperature proton conductivity of 1.7×10<sup>-2</sup> S/cm and 2.2×10<sup>-3</sup> S/cm was found for H<sub>2</sub>SO<sub>4</sub>-treated 2D and 3D COFs, respectively.

scholarly journals Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: Could the combination with other drugs improve its antitumoral effect?

2021 ◽  
Author(s):  
Javier Escudero ◽  
Victoria Heredia-Soto ◽  
Yiyin Wang ◽  
Patricia Ruiz ◽  
Alejandro Gallego ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Cell Line ◽  
Antitumour Activity ◽  
Three Dimensional ◽  
Soft Tissue Sarcomas ◽  
Migration And Invasion ◽  
2D And 3D ◽  
First Time ◽  
Dimensional Cell

Abstract Background Eribulin has shown antitumour activity in some soft tissue sarcomas (STSs), but it has only been approved for advanced liposarcoma (LPS). Methods In this study, we evaluated the effect of eribulin on proliferation, migration and invasion capabilities in LPS, leiomyosarcoma (LMS) and fibrosarcoma (FS) models, using both monolayer (2D) and three-dimensional (3D spheroid) cell cultures. Additionally, we explored combinations of eribulin with other drugs commonly used in the treatment of STS with the aim of increasing its antitumour activity. Results Eribulin showed activity inhibiting proliferation, 2D and 3D migration and invasion in most of the cell line models. Furthermore, we provide data that suggest for the first time a synergistic effect with ifosfamide in all models and with pazopanib in LMS as well as in myxoid and pleomorphic LPS. Conclusions Our results support the effect of eribulin on LPS, LMS and FS cell line models. The combination of eribulin with ifosfamide or pazopanib has shown in vitro synergy, which warrants further clinical research.

Covalent organic frameworks: an ideal platform for designing ordered materials and advanced applications

2021 ◽  
Author(s):  
Ruoyang Liu ◽  
Ke Tian Tan ◽  
Yifan Gong ◽  
Yongzhi Chen ◽  
Zhuoer Li ◽  
...  
Keyword(s):  
Covalent Organic Frameworks ◽  
2D And 3D ◽  
Advanced Applications

Covalent organic frameworks offer a molecular platform for integrating organic units into periodically ordered yet extended 2D and 3D polymers to create topologically well-defined polygonal lattices and built-in discrete micropores and/or mesopores.

scholarly journals Homogeneous 2D and 3D alignment of cardiomyocyte in dilated cardiomyopathy revealed by intravital heart imaging

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kiyoshi Masuyama ◽  
Tomoaki Higo ◽  
Jong-Kook Lee ◽  
Ryohei Matsuura ◽  
Ian Jones ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Cardiac Dysfunction ◽  
Three Dimensional ◽  
Single Layer ◽  
Specific Pattern ◽  
Two Dimensional ◽  
Heart Imaging ◽  
Novel Method ◽  
2D And 3D

AbstractIn contrast to hypertrophic cardiomyopathy, there has been reported no specific pattern of cardiomyocyte array in dilated cardiomyopathy (DCM), partially because lack of alignment assessment in a three-dimensional (3D) manner. Here we have established a novel method to evaluate cardiomyocyte alignment in 3D using intravital heart imaging and demonstrated homogeneous alignment in DCM mice. Whilst cardiomyocytes of control mice changed their alignment by every layer in 3D and position twistedly even in a single layer, termed myocyte twist, cardiomyocytes of DCM mice aligned homogeneously both in two-dimensional (2D) and in 3D and lost myocyte twist. Manipulation of cultured cardiomyocyte toward homogeneously aligned increased their contractility, suggesting that homogeneous alignment in DCM mice is due to a sort of alignment remodelling as a way to compensate cardiac dysfunction. Our findings provide the first intravital evidence of cardiomyocyte alignment and will bring new insights into understanding the mechanism of heart failure.

scholarly journals Do 3D Face Images Capture Cues of Strength, Weight, and Height Better than 2D Face Images do?

2021 ◽  
Vol 7 (3) ◽  
pp. 209-219
Author(s):  
Iris J Holzleitner ◽  
Alex L Jones ◽  
Kieran J O’Shea ◽  
Rachel Cassar ◽  
Vanessa Fasolt ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Physical Characteristics ◽  
Two Dimensional ◽  
3D Images ◽  
3D Face ◽  
Face Images ◽  
Similar Accuracy ◽  
2D And 3D ◽  
2D Images ◽  
Better Than

Abstract Objectives A large literature exists investigating the extent to which physical characteristics (e.g., strength, weight, and height) can be accurately assessed from face images. While most of these studies have employed two-dimensional (2D) face images as stimuli, some recent studies have used three-dimensional (3D) face images because they may contain cues not visible in 2D face images. As equipment required for 3D face images is considerably more expensive than that required for 2D face images, we here investigated how perceptual ratings of physical characteristics from 2D and 3D face images compare. Methods We tested whether 3D face images capture cues of strength, weight, and height better than 2D face images do by directly comparing the accuracy of strength, weight, and height ratings of 182 2D and 3D face images taken simultaneously. Strength, height and weight were rated by 66, 59 and 52 raters respectively, who viewed both 2D and 3D images. Results In line with previous studies, we found that weight and height can be judged somewhat accurately from faces; contrary to previous research, we found that people were relatively inaccurate at assessing strength. We found no evidence that physical characteristics could be judged more accurately from 3D than 2D images. Conclusion Our results suggest physical characteristics are perceived with similar accuracy from 2D and 3D face images. They also suggest that the substantial costs associated with collecting 3D face scans may not be justified for research on the accuracy of facial judgments of physical characteristics.

scholarly journals Cobalt-based magnetic Weyl semimetals with high-thermodynamic stabilities

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Wei Luo ◽  
Yuma Nakamura ◽  
Jinseon Park ◽  
Mina Yoon
Keyword(s):  
Tight Binding ◽  
Three Dimensional ◽  
Interlayer Coupling ◽  
First Principles Calculation ◽  
Optimization Approach ◽  
Binding Model ◽  
Nodal Lines ◽  
Weyl Semimetal ◽  
Topological Quantum ◽  
First Time

AbstractRecent experiments identified Co3Sn2S2 as the first magnetic Weyl semimetal (MWSM). Using first-principles calculation with a global optimization approach, we explore the structural stabilities and topological electronic properties of cobalt (Co)-based shandite and alloys, Co3MM’X2 (M/M’ = Ge, Sn, Pb, X = S, Se, Te), and identify stable structures with different Weyl phases. Using a tight-binding model, for the first time, we reveal that the physical origin of the nodal lines of a Co-based shandite structure is the interlayer coupling between Co atoms in different Kagome layers, while the number of Weyl points and their types are mainly governed by the interaction between Co and the metal atoms, Sn, Ge, and Pb. The Co3SnPbS2 alloy exhibits two distinguished topological phases, depending on the relative positions of the Sn and Pb atoms: a three-dimensional quantum anomalous Hall metal, and a MWSM phase with anomalous Hall conductivity (~1290 Ω−1 cm−1) that is larger than that of Co2Sn2S2. Our work reveals the physical mechanism of the origination of Weyl fermions in Co-based shandite structures and proposes topological quantum states with high thermal stability.

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