One-pot reductive amination of carboxylic acids: a sustainable method for primary amine synthesis

2020 ◽  
Vol 22 (15) ◽  
pp. 5105-5114
Author(s):  
Robin Coeck ◽  
Dirk E. De Vos
Keyword(s):  
Carboxylic Acids ◽  
Primary Amine ◽  
Reductive Amination ◽  
One Pot ◽  
Tungsten Catalysts

Recyclable ruthenium–tungsten catalysts perform excellently for the direct reductive amination of carboxylic acids, with up to 96% yield.

Synthesis of 3-(Cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8- carboxylic Acids Via an Efficient Three-component Condensation Reaction between Cyclohexylisocyanide and 2-Aminopyridine-3-carboxylic Acid in the Presence of Aromatic Aldehyde

2018 ◽  
Vol 21 (4) ◽  
pp. 298-301 ◽  
Author(s):  
Ghasem Marandi
Keyword(s):  
Biological Sciences ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
High Performance ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
New Materials ◽  
One Pot ◽  
High Yields ◽  
Benzaldehyde Derivatives

Aim and Objective: The reaction of cyclohexylisocyanide and 2-aminopyridine-3- carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2- arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. Material and Methods: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis. Results: In continuation of our attempts to develop simple one-pot routes for the synthesis of 3- (cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids, aromatic aldehydes with divers substituted show a high performance. Conclusion: In conclusion, this study introduces the art of combinatorial chemistry using a simple one-pot procedure for the synthesis of new materials which are interesting compounds in medicinal and biological sciences.

Cobalt encapsulated in N‑doped graphene sheet for one-pot reductive amination to synthesize secondary amines

2021 ◽  
Vol 505 ◽  
pp. 111504
Author(s):  
Lin Liu ◽  
Wenxiu Li ◽  
Ran Qi ◽  
Qingqing Zhu ◽  
Jing Li ◽  
...  
Keyword(s):  
Graphene Sheet ◽  
Reductive Amination ◽  
Secondary Amines ◽  
One Pot ◽  
Doped Graphene

scholarly journals Facile Synthesis of COF-Supported Reduced Pd-Based Catalyst for One-Pot Reductive Amination of Aldehydes

Catalysts ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 287
Author(s):  
Jianguo Liu ◽  
Mingyue Zhang ◽  
Longlong Ma
Keyword(s):  
Heterogeneous Catalysts ◽  
Reductive Amination ◽  
Secondary Amines ◽  
Metallic State ◽  
One Pot ◽  
Effective Synthesis ◽  
Pharmaceutical Industries ◽  
The One ◽  
Heterocyclic Aldehydes ◽  
Supported Pd

Dibenzylamine motifs are an important class of crucial organic compounds and are widely used in fine chemical and pharmaceutical industries. The development of the efficient, economical, and environmentally friendly synthesis of amines using transition metal-based heterogeneous catalysts remains both desirable and challenging. Herein, we prepared the covalent organic framework (COF)-supported heterogeneous reduced COF-supported Pd-based catalyst and used it for the one-pot reductive amination of aldehydes. There are both Pd metallic state and oxidated Pdσ+ in the catalysts. Furthermore, in the presence of the reduced COF-supported Pd-based catalyst, many aromatic, aliphatic, and heterocyclic aldehydes with various functional groups substituted were converted to their corresponding amines products in good to excellent selectivity (up to 91%) under mild reaction conditions (70 °C, 2 h, NH3, 20 bar H2). This work expands the covalent organic frameworks for the material family and its support catalyst, opening up new catalytic applications in the economical, practical, and effective synthesis of secondary amines.

One-pot reductive amination of aldehydes and ketones with α-picoline-borane in methanol, in water, and in neat conditions

Tetrahedron ◽  
2004 ◽  
Vol 60 (36) ◽  
pp. 7899-7906 ◽  
Author(s):  
Shinya Sato ◽  
Takeshi Sakamoto ◽  
Etsuko Miyazawa ◽  
Yasuo Kikugawa
Keyword(s):  
Reductive Amination ◽  
One Pot ◽  
Aldehydes And Ketones

Direct reductive amination of aldehydes using lithium-arene(cat.) as reducing system. A simple one-pot procedure for the synthesis of secondary amines

2012 ◽  
Vol 53 (25) ◽  
pp. 3156-3160 ◽  
Author(s):  
Fabiana Nador ◽  
Yanina Moglie ◽  
Andrés Ciolino ◽  
Adriana Pierini ◽  
Viviana Dorn ◽  
...  
Keyword(s):  
Reductive Amination ◽  
Secondary Amines ◽  
One Pot ◽  
System A

Mild one-pot conversion of carboxylic acids to amides or esters with Ph3P/trichloroisocyanuric acid

2005 ◽  
Vol 46 (35) ◽  
pp. 5945-5947 ◽  
Author(s):  
Rogério da C. Rodrigues ◽  
Igor M.A. Barros ◽  
Edson L.S. Lima
Keyword(s):  
Carboxylic Acids ◽  
One Pot ◽  
Trichloroisocyanuric Acid

One-Pot Reductive Amination of Carbonyl Compounds Using Sodium Borohydride–Amberlyst 15

2010 ◽  
Vol 40 (7) ◽  
pp. 951-956 ◽  
Author(s):  
Heshmatollah Alinezhad ◽  
Mahmood Tajbakhsh ◽  
Nastaran Mahdavi
Keyword(s):  
Sodium Borohydride ◽  
Carbonyl Compounds ◽  
Reductive Amination ◽  
One Pot ◽  
Amberlyst 15
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