In situ plasma-assisted synthesis of polydopamine-functionalized gold nanoparticles for biomedical applications

2020 ◽  
Vol 22 (19) ◽  
pp. 6588-6599
Author(s):  
Linh Nhat Nguyen ◽  
Neha Kaushik ◽  
Pradeep Lamichhane ◽  
Sohail Mumtaz ◽  
Ramhari Paneru ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Redox Reaction ◽  
Biomedical Applications ◽  
Functionalized Gold Nanoparticles

The green fabrication of polydopamine-functionalized gold nanoparticles by using plasma–liquid interaction to trigger a redox reaction and their biomedical applications.

Development of novel bioelectrocatalytic platform based on in situ generated gold nanoparticles for biomedical applications

2012 ◽  
Vol 1418 ◽  
Author(s):  
Prem C. Pandey ◽  
Dheeraj S. Chauhan
Keyword(s):  
Hydrogen Peroxide ◽  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
Potassium Ferricyanide ◽  
Organically Modified Silicates ◽  
Organically Modified ◽  
Electrocatalytic Determination ◽  
Aunp Surface

ABSTRACTGold nanoparticles (AuNp) formed using alkoxysilane precursors are utilized in the development of thin organically modified silicates (ormosil) films. The resulting films are optically transparent thereby retaining the optical properties of AuNp. Surface morphology shows that the in situ generated AuNp retained their nanogeometry in the ormosil films. An application of the AuNp encapsulated ormosils is shown in electrocatalytic determination of hydrogen peroxide. For this purpose, potassium ferricyanide is chosen as electron transfer mediator and is encapsulated in the films. Results show that the presence of AuNp in the ormosil matrix dramatically improves the electrochemical behavior of potassium ferricyanide. The ormosil films are utilized for electrocatalytic determination of hydrogen peroxide. In order to investigate the biocompatibility of the ormosil film, horseradish peroxidase (HRP) is incorporated resulting in improvement in oxidation and reduction of peroxide.

scholarly journals Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Aaron S. Schwartz-Duval ◽  
Christian J. Konopka ◽  
Parikshit Moitra ◽  
Enrique A. Daza ◽  
Indrajit Srivastava ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Incubation Time ◽  
Biomedical Applications ◽  
Gold Clusters ◽  
Chloroauric Acid ◽  
Delivery Vector ◽  
Biomedical Potential ◽  
Ionic Gold

Abstract Various cancer cells have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid is introduced to their cellular microenvironment. But their biomedical applications are limited, particularly considering the millimolar concentrations and longer incubation period of ionic gold. Here, we describe a simplistic method of intracellular biomineralization to produce plasmonic gold nanoparticles at micromolar concentrations within 30 min of application utilizing polyethylene glycol as delivery vector for ionic gold. We have characterized this process for intracellular gold nanoparticle formation, which progressively accumulates proteins as the ionic gold clusters migrate to the nucleus. This nano-vectorized application of ionic gold emphasizes its potential biomedical opportunities while reducing the quantity of ionic gold and required incubation time. To demonstrate its biomedical potential, we further induce in-situ biosynthesis of gold nanoparticles within MCF7 tumor mouse xenografts which is followed by its photothermal remediation.

Design and Development of Antibody Functionalized Gold Nanoparticles for Biomedical Applications

2021 ◽  
Vol 21 (5) ◽  
pp. 2834-2840
Author(s):  
José M. Abad ◽  
Sara Puertas ◽  
Daniel Pérez ◽  
Christian Sánchez-Espinel
Keyword(s):  
Gold Nanoparticles ◽  
Metal Binding ◽  
Biomedical Applications ◽  
Antibody Immobilization ◽  
Metal Chelation ◽  
Igg Antibodies ◽  
Key Factors ◽  
Functionalized Gold Nanoparticles ◽  
Oriented Immobilization ◽  
Insight Into

Antibody-functionalized gold nanoparticle constitutes a powerful interface biosystem for biomedical applications where the properties of gold nanoparticles and the specificity of antibody–antigen interactions are combined. This study provides insight into the key factors for the development of antibody functionalized gold nanoparticles focusing on the immobilization of the antibody. Here, we address an oriented antibody immobilization procedure on gold nanoparticles. It comprises chelatemodified gold nanoparticles that are designed for oriented immobilization of IgG antibodies (end on spatial orientation) through the metal-chelation to histidine-rich metal binding site in the heavy chain (Fc) of the antibody.

scholarly journals Selective colorimetric NO(g) detection based on the use of modified gold nanoparticles using click chemistry

2015 ◽  
Vol 51 (15) ◽  
pp. 3077-3079 ◽  
Author(s):  
Almudena Martí ◽  
Ana M. Costero ◽  
Pablo Gaviña ◽  
Margarita Parra
Keyword(s):  
Gold Nanoparticles ◽  
Click Chemistry ◽  
Click Reaction ◽  
Colorimetric Probe ◽  
Functionalized Gold Nanoparticles

A new colorimetric probe for the detection of NO(g) based on the use of functionalized gold nanoparticles is described. The sensing protocol is based on a click reaction catalized by Cu(i) which is generated in situ from the reduction of Cu(ii) by NO(g).

Biomedical Applications of Functionalized Gold Nanoparticles: A Review

2021 ◽  
Author(s):  
Kazem Nejati ◽  
Mehdi Dadashpour ◽  
Tohid Gharibi ◽  
Hassan Mellatyar ◽  
Abolfazl Akbarzadeh
Keyword(s):  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
Functionalized Gold Nanoparticles
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