Drug-Guided Screening for Pancreatic Lipase Inhibitors in Functional Foods

2021 ◽  
Author(s):  
Qing-Juan Tang ◽  
Lujia Zhang ◽  
Jinkai Zheng ◽  
Jia Song ◽  
Xin Chen ◽  
...  
Keyword(s):  
Side Effects ◽  
Human Health ◽  
Chronic Diseases ◽  
Pancreatic Lipase ◽  
Functional Foods ◽  
Therapeutic Effects ◽  
Therapeutic Alternative ◽  
Pancreatic Lipase Inhibitors ◽  
Great Harm

Chronic diseases, such as obesity, cause great harm to human health. Conventional drugs have promising therapeutic effects but also cause significant side effects. Functional foods are an excellent therapeutic alternative...

scholarly journals MetaMed: Linking Microbiota Functions with Medicine Therapeutics

mSystems ◽  
2019 ◽  
Vol 4 (5) ◽  
Author(s):  
Han Zhao ◽  
Shaliu Fu ◽  
Yifei Yu ◽  
Zhanbing Zhang ◽  
Ping Li ◽  
...  
Keyword(s):  
Side Effects ◽  
Clinical Research ◽  
Human Health ◽  
Human Microbiome ◽  
Rich Source ◽  
Therapeutic Effects ◽  
Link Type ◽  
Integrative System ◽  
Pharmaceutical Applications ◽  
Mapping System

ABSTRACT Understanding how the human microbiome affects human health has consequences for treating disease and minimizing unwanted side effects in clinical research. Here, we present MetaMed (http://metamed.rwebox.com/index), a novel and integrative system-wide correlation mapping system to link bacterial functions and medicine therapeutics, providing novel hypotheses for deep investigation of microbe therapeutic effects on human health. Furthermore, comprehensive relationships between microbes living in the environment and drugs were discovered, providing a rich source for discovering microbiota metabolites with great potential for pharmaceutical applications.

scholarly journals Probiotics, prebiotics and antioxidants as functional foods.

2005 ◽  
Vol 52 (3) ◽  
pp. 665-671 ◽  
Author(s):  
Włodzimierz Grajek ◽  
Anna Olejnik ◽  
Anna Sip
Keyword(s):  
Human Health ◽  
Chronic Diseases ◽  
Functional Foods ◽  
Natural Antioxidants ◽  
Animal Origin ◽  
Bacterial Strains ◽  
Animal Tissues ◽  
Active Compounds ◽  
Physiologically Active Compounds

The term "functional foods" comprises some bacterial strains and products of plant and animal origin containing physiologically active compounds beneficial for human health and reducing the risk of chronic diseases. Among the best known functional compounds probiotics, prebiotics and natural antioxidants should be given as examples. These substances can be obtained by biotechnological methods and by extraction from plant or animal tissues.

Rapid screening of pancreatic lipase inhibitors from Monascus-fermented rice by ultrafiltration liquid chromatography-mass spectrometry

2017 ◽  
Vol 9 (23) ◽  
pp. 3422-3429 ◽  
Author(s):  
Yu-Xiang Fang ◽  
Hui-Peng Song ◽  
Jin-Xiu Liang ◽  
Ping Li ◽  
Hua Yang
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Molecular Docking ◽  
Bioactive Compounds ◽  
Pancreatic Lipase ◽  
Functional Foods ◽  
Rapid Screening ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Pancreatic Lipase Inhibitors

Ultrafiltration LC-MS, affinity-guided isolation and molecular docking were integrated into one strategy to discover bioactive compounds from functional foods.

Methotrexate Therapy in Obstetricaĺ Diseases

2016 ◽  
Vol 4 (1) ◽  
pp. 9 ◽  
Author(s):  
Aneta Tomescu ◽  
Rodica Sîrbu ◽  
Stelian Paris ◽  
Emin Cadar ◽  
Cristina Luiza Erimia ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
Side Effects ◽  
Ectopic Pregnancy ◽  
Malignant Disease ◽  
Surgical Intervention ◽  
Hydatidiform Mole ◽  
Medical Abortion ◽  
Methotrexate Therapy ◽  
Therapeutic Effects ◽  
Neoplastic Diseases

Our study is a rewiew of Methotrexate therapy in obstetrica? diseases such us: hydatidiform mole, and medical abortion. In the medical world, methotrexate is a citostatic drug used in neoplastic diseases. The clinical pharmacology data regarding methotrexate is presented, alongside route of administration and therapeutic effects in malignant disease, hydatiform mole, and medical abortion. The use of methotrexate in medical abortion and ectopic pregnancy is a great accomplishment, as it replaces a surgical intervention marred by characteristic side effects, with similar results.

Methotrexate Therapy in Obstetricaĺ Diseases

2016 ◽  
Vol 2 (1) ◽  
pp. 9 ◽  
Author(s):  
Aneta Tomescu ◽  
Rodica Sîrbu ◽  
Stelian Paris ◽  
Emin Cadar ◽  
Cristina Luiza Erimia ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
Side Effects ◽  
Ectopic Pregnancy ◽  
Malignant Disease ◽  
Surgical Intervention ◽  
Hydatidiform Mole ◽  
Medical Abortion ◽  
Methotrexate Therapy ◽  
Therapeutic Effects ◽  
Neoplastic Diseases

Our study is a rewiew of Methotrexate therapy in obstetrica? diseases such us: hydatidiform mole, and medical abortion. In the medical world, methotrexate is a citostatic drug used in neoplastic diseases. The clinical pharmacology data regarding methotrexate is presented, alongside route of administration and therapeutic effects in malignant disease, hydatiform mole, and medical abortion. The use of methotrexate in medical abortion and ectopic pregnancy is a great accomplishment, as it replaces a surgical intervention marred by characteristic side effects, with similar results.

EFFECTS OF “HOE HOA TAN II” REMEDY IN THE TREATMENT OF INTERNAL HAEMORROHIDS GRADE I, II AND III

2015 ◽  
pp. 80-85
Author(s):  
Van Anh Nguyen ◽  
Van Nhan Le ◽  
Nguyen Nhu Phuong Phan
Keyword(s):  
Side Effects ◽  
Key Words ◽  
Patient Group ◽  
Controlled Study ◽  
Therapeutic Effects ◽  
Radix Angelicae Sinensis ◽  
Randomised Controlled Study ◽  
Citrus Deliciosa ◽  
Randomised Controlled ◽  
Angelicae Sinensis

Objectives: To investigate and evaluate the therapeutic effects of Hoe hoa tan II in the treatment of internal haemorroids grade I, II and III. Ingredients of the remedy include: Hoe Hoa (Styphonolonium japonicum), Chi xac (Fructus citri Aurantii), Hau phac (Magnolia offinalis), Tran bi (Citrus deliciosa Tenore), Thuong thuat (Atractylodes lancea), O mai (Armeniaca vulgaris Lamk), Cam thao (Clycyrrhiza uralensis), Duong quy (Radix Angelicae Sinensis). Subjects and methods: Randomised controlled study (RCT) has been conducted on 60 patients which were divided into two groups, i.e. the first 30 patient group were treated with Hoe hoa tan II remedy 20 g, and the second 30 patient group were treated with Daflon 500 mg in the course of 14 days. Results: Study showed that Hoe hoa tan II has helped improve symptoms of internal haemorroids grade I, II and III such as bleeding, anal exudation, pain, reducing the size of the haemorroid tissues. The remedy has been shown to have the most significant effect on relieving constipation which is typical in haemorroids. The study also revealed no unwanted effects caused by this formula. Conclusion: Hoe hoa tan II can be therapeutically used to treat internal haemorroids grade I, II and III without causing any serious side effects. Key words: Hoe hoa tan II, internal haemorroids grade I, II, III.

A near-infrared fluorescent probe targeting mitochondria for sulfite detection and its application in food and biology

2021 ◽  
Author(s):  
Jianbin Chao ◽  
Zhuo Wang ◽  
Yongbin Zhang ◽  
Fangjun Huo ◽  
Caixia Yin
Keyword(s):  
Cardiovascular Diseases ◽  
Sulfur Dioxide ◽  
Human Health ◽  
Fluorescent Probe ◽  
Respiratory Diseases ◽  
Near Infrared ◽  
Air Pollutant ◽  
Great Harm

Abstract: Sulfur dioxide (SO2) is the main air pollutant in the environment, causing great harm to human health. Abnormal SO2 levels are usually associated with some respiratory diseases, cardiovascular diseases,...

scholarly journals Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wan Fatin Amira Wan Mohd Zawawi ◽  
M. H. Hibma ◽  
M. I. Salim ◽  
K. Jemon
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Side Effects ◽  
Immune Cells ◽  
Infrared Radiation ◽  
Near Infrared ◽  
Tumor Regression ◽  
Immunohistochemical Analysis ◽  
Therapeutic Effects ◽  
Near Infrared Radiation

AbstractBreast cancer is the most common cancer that causes death in women. Conventional therapies, including surgery and chemotherapy, have different therapeutic effects and are commonly associated with risks and side effects. Near infrared radiation is a technique with few side effects that is used for local hyperthermia, typically as an adjuvant to other cancer therapies. The understanding of the use of near NIR as a monotherapy, and its effects on the immune cells activation and infiltration, are limited. In this study, we investigate the effects of HT treatment using NIR on tumor regression and on the immune cells and molecules in breast tumors. Results from this study demonstrated that local HT by NIR at 43 °C reduced tumor progression and significantly increased the median survival of tumor-bearing mice. Immunohistochemical analysis revealed a significant reduction in cells proliferation in treated tumor, which was accompanied by an abundance of heat shock protein 70 (Hsp70). Increased numbers of activated dendritic cells were observed in the draining lymph nodes of the mice, along with infiltration of T cells, NK cells and B cells into the tumor. In contrast, tumor-infiltrated regulatory T cells were largely diminished from the tumor. In addition, higher IFN-γ and IL-2 secretion was observed in tumor of treated mice. Overall, results from this present study extends the understanding of using local HT by NIR to stimulate a favourable immune response against breast cancer.

scholarly journals Research Advances on Health Effects of Edible Artemisia Species and Some Sesquiterpene Lactones Constituents

Foods ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 65
Author(s):  
Antoaneta Trendafilova ◽  
Laila M. Moujir ◽  
Pedro M. C. Sousa ◽  
Ana M. L. Seca
Keyword(s):  
Adverse Effects ◽  
Health Effects ◽  
Functional Foods ◽  
Sesquiterpene Lactones ◽  
Therapeutic Effects ◽  
Nutritional Properties ◽  
Food Industries ◽  
Food Applications ◽  
Artemisia Species

The genus Artemisia, often known collectively as “wormwood”, has aroused great interest in the scientific community, pharmaceutical and food industries, generating many studies on the most varied aspects of these plants. In this review, the most recent evidence on health effects of edible Artemisia species and some of its constituents are presented and discussed, based on studies published until 2020, available in the Scopus, Web of Sciences and PubMed databases, related to food applications, nutritional and sesquiterpene lactones composition, and their therapeutic effects supported by in vivo and clinical studies. The analysis of more than 300 selected articles highlights the beneficial effect on health and the high clinical relevance of several Artemisia species besides some sesquiterpene lactones constituents and their derivatives. From an integrated perspective, as it includes therapeutic and nutritional properties, without ignoring some adverse effects described in the literature, this review shows the great potential of Artemisia plants and some of their constituents as dietary supplements, functional foods and as the source of new, more efficient, and safe medicines. Despite all the benefits demonstrated, some gaps need to be filled, mainly related to the use of raw Artemisia extracts, such as its standardization and clinical trials on adverse effects and its health care efficacy.

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