Impact of citrus flavonoid supplementation on inflammation in lipopolysaccharide-induced periodontal disease in mice

2021 ◽  
Author(s):  
Jhonatan de Souza Carvalho ◽  
Dania Ramadan ◽  
Vinícius de Paiva Gonçalves ◽  
Patricia Milagros Maquera-Huacho ◽  
Renata Pires Assis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Periodontal Disease ◽  
And Oxidative Stress

In general, the consumption of flavonoid-rich foods may influence the control/dysregulation of the magnitude and duration of inflammation and oxidative stress, which are known to contribute to multiple pathologies. Information...

Effects of an ethanol extract fromLactobacillus paracaseisubsp.paracaseiNTU 101 fermented skimmed milk on lipopolysaccharide-induced periodontal inflammation in rats

2018 ◽  
Vol 9 (9) ◽  
pp. 4916-4925 ◽  
Author(s):  
Te-Hua Liu ◽  
Tsung-Yu Tsai ◽  
Tzu-Ming Pan
Keyword(s):  
Oxidative Stress ◽  
Periodontal Disease ◽  
Inflammatory Cytokine ◽  
Alveolar Bone ◽  
Ethanol Extract ◽  
Alveolar Bone Loss ◽  
Periodontal Inflammation ◽  
Cytokine Levels ◽  
Skimmed Milk ◽  
And Oxidative Stress

NTU 101-fermented skimmed milk ethanol extract (NTU101FMEE) decreased pro-inflammatory cytokine levels and oxidative stress in the gingival tissues and serum of periodontal disease rat. NTU101FMEE inhibited alveolar bone loss induced by periodontal disease.

scholarly journals Periodontal Disease-Induced Atherosclerosis and Oxidative Stress

Antioxidants ◽  
2015 ◽  
Vol 4 (3) ◽  
pp. 577-590 ◽  
Author(s):  
Tomoko Kurita-Ochiai ◽  
Ru Jia ◽  
Yu Cai ◽  
Yohei Yamaguchi ◽  
Masafumi Yamamoto
Keyword(s):  
Oxidative Stress ◽  
Periodontal Disease ◽  
And Oxidative Stress

scholarly journals The Connection of Periodontal Disease and Diabetes Mellitus: The Role of Matrix Metalloproteinases and Oxidative Stress

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Dragana Stanisic ◽  
Radmila Obradovic ◽  
Sanja Vujovic ◽  
Milica Jovanovic ◽  
Vladimir Zivkovic
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Matrix Metalloproteinases ◽  
Periodontal Disease ◽  
Membrane Receptors ◽  
World Health ◽  
Dental Biofilm ◽  
Periodontal Tissues ◽  
And Oxidative Stress

Abstract Diabetes mellitus, a chronic disease considered by the World Health Organization to be an epidemic, is now recognized as one of the factors behind the onset of periodontal disease. The connection between periodontal disease, which is an irreversible inflammatory disease of the supporting tissue of the teeth, and systemic diseases is reflected in the existence of common risk factors, subgingival dental biofilm, as a constant source of proinflamma-tory cytokines synthesized intensely in inflammatory periodontium. Diabetes mellitus leads to increased oxidative stress in periodontal tissues causing worsening of the disease and periodontopathy exacerbates deficiency of pancreatic β-cells. The most important role in primary inflammatory response in the pathogenesis of periodontopathy is played by neutrophils. Neutrophils cause periodontium destruction by the release of enzymes (matrix metalloproteinases), cytotoxic substances (free radicals, reactive oxygen and nitrogen species) and the expression of membrane receptors. Matrix metalloproteinases within the “protease network” are critical to many physiological and pathological processes, including immunity, inflammation, bone resorption and wound healing. Matrix metalloproteinases levels are elevated in patients with metabolic syndrome and diabetes mellitus, which may contribute to more frequent complications. In this paper, the review of available literature data shows the correlation between periodontal disease and diabetes mellitus, as well as the role of matrix metalloproteinases and oxidative stress in these. In this regard, determining the value of matrix metalloproteinases may be helpful in the diagnosis of periodontal disease complicated by diabetes mellitus. Also, the parameters of oxidative stress could help to clarify the mechanisms of pathogenesis and etiology of periodontal disease, or indicate the potential benefit of antioxidant supplementation in these individuals. As the role of matrix metalloproteinases has not been fully clarified in the pathogenesis of periodontopathy, additional studies will be needed to indicate their importance.

scholarly journals Proinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease

2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
Ivan Borges Jr. ◽  
Emília Addison Machado Moreira ◽  
Danilo Wilhem Filho ◽  
Tiago Bittencourt de Oliveira ◽  
Marcelo Barreto Spirelle da Silva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Periodontal Disease ◽  
Gingival Tissue ◽  
Control Group ◽  
Myeloperoxidase Activity ◽  
Enzymatic Antioxidants ◽  
Oxidative Stress Markers ◽  
Oxidative Stress Biomarkers ◽  
Stress Markers ◽  
And Oxidative Stress

Objective. To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis.Subject and methods. Eighteen subjects were divided in two groups: experimental (age52.9±5.0) and control (age51.1±9.6). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Studentttest andP<.05.Results. Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group (P<.05).Conclusion. The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.

scholarly journals Evaluation of Oxidative Stress before and after Using Laser and Photoactivation Therapy as Adjuvant of Non-Surgical Periodontal Treatment in Patients with Rheumatoid Arthritis

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 226
Author(s):  
Maria-Alexandra Martu ◽  
Petra Surlin ◽  
Luminita Lazar ◽  
George Alexandru Maftei ◽  
Ionut Luchian ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Periodontal Disease ◽  
Periodontal Therapy ◽  
Periodontal Treatment ◽  
Oxidative Stress Markers ◽  
Treatment Needs ◽  
Disease Treatment ◽  
Stress Markers ◽  
And Oxidative Stress

(1) Background: The aim of this split-mouth design study was to analyze the clinical periodontal indexes and oxidative stress markers in gingival crevicular fluid modifications after three periodontal disease treatment possibilities (scaling and root planning—SRP; SRP and diode laser—L; SRP and photodynamic therapy—PDT). (2) Methods: The study was conducted on 52 patients: systemically healthy subjects with periodontal disease—non-RA (n = 26); and test group (n = 26) subjects with rheumatoid arthritis and periodontal disease—RA. Clinical periodontal measurements (probing depth—PD; Löe and Silness gingival index—GI; papillary bleeding index—PBI; and periodontal community index of treatment needs—CPITN) and oxidative stress markers (8-hydroxy-2’-deoxyguanosine (8-OHdG) and 4 hydroxynonenal (4-HNE)) were analyzed at baseline (T0), after three sessions of periodontal treatment (T1), and 6 months after treatment (T2). (3) Results: Periodontal therapy improved clinical periodontal measurements and oxidative stress markers in both analyzed groups, with supplementary benefits for laser- and PDT-treated periodontal pockets. (4) Conclusions: The analyzed oxidative stress markers decreased significantly following non-surgical periodontal therapy in both rheumatoid arthritis and systemically healthy patients. All the periodontal disease treatment possibilities analyzed in this study offered clinical and paraclinical improvements; however, the association of laser with SRP and photodisinfection with SRP yielded the best clinical and paraclinical outcomes when compared to SRP alone.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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