Hypoglycemic activity of Origanum vulgare L. and its main chemical constituents identified with HPLC-ESI-QTOF-MS

2021 ◽  
Vol 12 (6) ◽  
pp. 2580-2590
Author(s):  
Huawei Yu ◽  
Panpan Zhang ◽  
Hongbing Liu ◽  
Xiaojuan Sun ◽  
Jichao Liang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phenolic Compounds ◽  
Leaf Extract ◽  
Chemical Constituents ◽  
Lipid Synthesis ◽  
Signalling Pathway ◽  
Hypoglycemic Activity ◽  
Origanum Vulgare ◽  
Tof Ms ◽  
Stress Signalling

Origanum vulgare L. leaf extract showed promising hypoglycemic activity through gluconeogenesis, lipid synthesis and relieving oxidative stress signalling pathway, and its potential active phenolic compounds were also identified by HPLC-ESI-Q-TOF-MS method.

scholarly journals Classification of drug molecules for oxidative stress signalling pathway

2019 ◽  
Vol 13 (5) ◽  
pp. 243-250 ◽  
Author(s):  
Nikhil Verma ◽  
Harpreet Singh ◽  
Divya Khanna ◽  
Prashant Singh Rana ◽  
Sanjay Kumar Bhadada
Keyword(s):  
Oxidative Stress ◽  
Signalling Pathway ◽  
Drug Molecules ◽  
Stress Signalling

scholarly journals Isolation of Phenolics from Rhizophora mangle by Combined Counter-current Chromatography and Gel-Filtration

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901
Author(s):  
Fernanda das Neves Costa ◽  
Marcos Daniel da Silva ◽  
Ricardo Moreira Borges ◽  
Gilda Guimarães Leitão
Keyword(s):  
Phenolic Compounds ◽  
Leaf Extract ◽  
Gel Filtration ◽  
Rhizophora Mangle ◽  
Solvent System ◽  
Hydroxybenzoic Acid ◽  
Etoac Extract ◽  
Counter Current ◽  
First Time ◽  
Tof Ms

Nine phenolic compounds, quercetin, epi-catechin, catechin, 4-hydroxybenzoic acid, kaempferol 3- O-β-glucopyranoside, quercetin 3- O-β-glucopyranoside, quercetin 3- O-6″- trans-coumaroyl-β-glucoside, kaempferol 3- O-β-rutinoside and quercetin 3- O-β-rutinoside, were isolated from the EtOAc leaf extract of Rhizophora mangle (Rhizophoraceae) combining counter-current chromatography (CCC) and gel-filtration. A solvent system of n-hexane-ethyl acetate-methanol-water (1.5:6:1.5:6) was employed at the preliminary stage of EtOAc extract fractionation as it was shown to contain compounds that differed highly in their hydrophobicity. The obtained fractions were further purified by either CCC or gel-filtration depending on their complexity. The isolated compounds were analyzed by NMR spectroscopy and the proposed structures were confirmed by HRES/ESI/TOF MS. Some of these compounds were isolated and/or identified for the first time in R. mangle.

scholarly journals Antioxidant Activity and Flavonoids Identification by LC-MS/MS Analysis in Leaf Extract from Trattinnickia rhoifolia Willd

2019 ◽  
Vol 8 (2) ◽  
pp. 13-34
Author(s):  
Lilian Marigo Magalhaes ◽  
Valeria Dornelles Gindri Sinhorin ◽  
Camila Cristina Pereira de Souza ◽  
Rogério de Campos Bicudo ◽  
Adilson Paulo Sinhorin
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Leaf Extract ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
Glutathione S Transferase ◽  
Hypolipidemic Action ◽  
Protein Thiols ◽  
First Time

The objectives of this work were to evaluate the antioxidant and hepatoprotective activities in the oxidative stress model induced by paracetamol in male Swiss mice, to evaluate the hypoglycemic and hypolipidemic action and to identify flavonoids in the leaves ethanolic extract from Trattinnickia rhoifolia. By the LC-MS / MS method, eight flavonoids were identified in the hydromethanolic (HM) and ethyl acetate (EA) fractions, except for Amentoflavone, the flavonoids Apigenin, Canferol, Luteolin, Quercetin, Quercetin-3-β-d-glucoside, Rutin and Taxifoline were identified for the first time in this species. These fractions were evaluated for antioxidant capacity (DPPH— test) and their protective effect in vivo through the analysis of superoxide dismutase, catalase, glutathione-s-transferase, non-protein thiols, ascorbic acid, TBARS and carbonylated proteins. The data showed that EA has antioxidant capacity and superior oxidative stress repair in chemical and biological analyzes, besides hypoglycemic and hypolipidemic action. Thus, the present work contributes significantly to the literature, since it is the first study that identifies the chemical constituents and pharmacological properties of leaves extract from T. rhoifolia.

scholarly journals Phytochemical Screening, HPTLC Fingerprint Analysis of Leaf Extract of Bridelia montana (Roxb) Willd

2017 ◽  
Vol 9 (6) ◽  
Author(s):  
B. Vinatha ◽  
Vijaya Kuchana ◽  
J. Shreelekha ◽  
K. Sreeharshini ◽  
I Anvesh Reddy ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Ethyl Alcohol ◽  
Leaf Extract ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
Phytochemical Screening ◽  
Fingerprint Analysis ◽  
Major Chemical ◽  
Ethanolic Leaf Extract

ABSTRACT This research analyzed the major chemical constituents present in the ethanolic extract of the leaves of Bridelia montana (ROXB) WILLD. The leaves of Bridelia montana were collected, powdered, de-fatted with n-hexane and then extracted with 90%ethyl alcohol. Preliminary phytochemical screening of the ethanolic leaf extract of Bridelia montana showed the presence of chemical constituents like alkaloids, glycosides, phenolic compounds, tannins and resins. HPTLC fingerprint analysis of the extract was carried out using CAMAG HPTLC system equipped with Linomat 5 sample applicator, UV cabinet and WIN-CATS-4 software. The results from HPTLC fingerprint analysis of the ethanolic leaf extract of Bridelia montana revealed the presence of 6 polyvalent constituents.

scholarly journals Anti-hyperlipidemic Activity of Lannea coramandelica Leaf Extract Against Experimentally Induced Hyperlipidemia in Rats

2020 ◽  
Vol 11 (4) ◽  
pp. 5422-5425
Author(s):  
Sekkizhar M ◽  
Jaikumar S ◽  
Asokan B R
Keyword(s):  
Oxidative Stress ◽  
Pharmacological Activity ◽  
Human Body ◽  
Leaf Extract ◽  
Chemical Constituents ◽  
Serum Levels ◽  
The Body ◽  
Chemical Components ◽  
Native Plant ◽  
Tropical Countries

Hyperlipidemia and hypercholesterolemia are interrelated terms and the same course of disorders which raise the serum levels of cholesterol and triglycerides. Herbs are used for treating diseases and used in the traditional systems of medicines like Ayurveda. As science is evolving, research to prove the pharmacological activity of the herbs and establishing scientific proof is also important. Lannea coramandelica is a native plant for tropical countries like India. It is considered one of the lifesavers of the area with abundant polyphenols, flavonoids, gums and other chemical constituents. Most of the antioxidant chemical components like flavonoids are potent in treating and lowering lipids in the body and reduces the oxidative stress in the human body to process fats. Lannea coramandelica has been proven to have vast amounts of flavonoids and antioxidant principles. Current research has been designed to confirm the hyperlipidemia controlling property of Lannea coramandelica extracts. The Lannea coramandelica extract showed a better hyperlipidemic activity at a dose of 500mg/kg in both the events.

scholarly journals Origanum vulgare L. leaf extract alleviates finasteride-induced oxidative stress in mouse liver and kidney

2021 ◽  
Vol 11 (5) ◽  
pp. 194
Author(s):  
Zhong-Yang Ding ◽  
Qi-Feng Sun ◽  
Shi-Xiang Chen ◽  
Zhang-Feng Tang ◽  
Xiao-Yi Song ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Liver ◽  
Leaf Extract ◽  
Origanum Vulgare ◽  
Liver And Kidney

Composition and variability of phenolic compounds in Origanum vulgare from Lithuania

Biologija ◽  
2008 ◽  
Vol 54 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Jolita Radušienė ◽  
Liudas Ivanauskas ◽  
Valdimaras Janulis ◽  
Valdas Jakštas
Keyword(s):  
Phenolic Compounds ◽  
Origanum Vulgare

HPLC-TOF/MS in identification of chemical constituents of Fuzhengpingxiao Capsule

2013 ◽  
Vol 32 (7) ◽  
pp. 770-779
Author(s):  
Liang ZHAO ◽  
Wen-jun TIAN ◽  
Lei LU ◽  
Hai ZHANG ◽  
Xin-xia WANG ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Tof Ms
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