Plantaginis Semen polysaccharides ameliorate renal damage through regulating NLRP3 inflammasome in gouty nephropathy rats

2021 ◽  
Author(s):  
Hong Zhao ◽  
Jiao Xu ◽  
Ruiyao Wang ◽  
Weiwei Tang ◽  
Lingzhou Kong ◽  
...  
Keyword(s):  
Renal Disease ◽  
Nlrp3 Inflammasome ◽  
Renal Damage ◽  
Inflammatory Event ◽  
Plantaginis Semen ◽  
Msu Crystals

Gouty nephropathy (GN) is considered to be a prevalent renal disease and is an inflammatory event mainly induced by MSU crystals.

scholarly journals Lower Temperatures Exacerbate NLRP3 Inflammasome Activation by Promoting Monosodium Urate Crystallization, Causing Gout

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1919
Author(s):  
Huijeong Ahn ◽  
Gilyoung Lee ◽  
Geun-Shik Lee
Keyword(s):  
Environmental Factor ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Optimal Temperature ◽  
Monosodium Urate ◽  
Nlrp3 Inflammasome Activation ◽  
Hyperthermia Therapy ◽  
Effects Of Temperature ◽  
Lower Temperature ◽  
Msu Crystals

Gout is a recurrent and chronic form of arthritis caused by the deposition of monosodium urate (MSU) crystals in the joints. Macrophages intake MSU crystals, the trigger for NLRP3 inflammasome activation, which leads to the release of interleukin (IL)-1β and results in the flaring of gout. The effects of temperature, an environmental factor for MSU crystallization, on IL-1β secretion have not been well studied. This study examined the effects of temperature on inflammasome activation. Specific triggers activated canonical inflammasomes (NLRP3, NLRC4, and AIM2) in murine macrophages at various temperatures (25, 33, 37, 39, and 42 °C). The maturation of IL-1β and caspase-1 was measured as an indicator for inflammasome activation. As expected, the optimal temperature of inflammasome activation was 37 °C. The MSU crystal-mediated activation of inflammasome increased at temperatures lower than 37 °C and decreased at higher temperatures. MSU crystals at lower temperatures enhanced IL-1β secretion via the NLRP3 inflammasome pathway. A lower temperature promoted the formation of MSU crystals without changing phagocytosis. Overall, lower temperatures form more MSU crystals and enhance NLRP3 inflammasome activation. In light of these findings, it is possible that hyperthermia therapy may reduce gout flaring.

scholarly journals Integrated Fecal Microbiome and Serum Metabolomics Analysis Reveals Abnormal Changes in Rats with Immunoglobulin A Nephropathy and the Intervention Effect of Zhen Wu Tang

2021 ◽  
Vol 11 ◽  
Author(s):  
Jicheng Li ◽  
Yiwen Cao ◽  
Ruirui Lu ◽  
Honglian Li ◽  
Yu Pang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Renal Disease ◽  
Intestinal Microbiota ◽  
Renal Damage ◽  
Immunoglobulin A ◽  
Metabolic Phenotype ◽  
Immunoglobulin A Nephropathy ◽  
Metabolic Phenotypes ◽  
Potential Relationship ◽  
Rdna Sequencing

Immunoglobulin A nephropathy (IgAN), an autoimmune renal disease with complicated pathogenesis, is one of the principal reasons for end-stage renal disease in the clinic. Evidence has linked apparent alterations in the components of the microbiome and metabolome to renal disease in rats. However, thus far, there is insufficient evidence that supports the potential relationship between gut microbiome, circulating metabolites, and IgAN. This study was designed to probe the effects of IgAN on intestinal microecology and metabolic phenotypes and to understand the possible underlying mechanisms. Fecal and serum samples were collected from IgAN rats. Composition of the gut microbiota and biochemical changes in the metabolites was analyzed using 16S rDNA sequencing and untargeted metabolomics. The IgAN rats exhibited renal insufficiency and increased concentration of 24-h urine protein, in addition to deposition of IgA and IgG immune complexes in the kidney tissues. There was a disturbance in the balance of gut microbiota in IgAN rats, which was remarkably associated with renal damage. Marked changes in microbial structure and function were accompanied by apparent alterations in 1,403 serum metabolites, associated with the disorder of energy, carbohydrate, and nucleotide metabolisms. Administration of Zhen Wu Tang ameliorated microbial dysbiosis and attenuated the renal damage. Besides, treatment with Zhen Wu Tang modulated the metabolic phenotype perturbation in case of gut microbiota dysbiosis in IgAN rats. In conclusion, these findings provided a comprehensive understanding of the potential relationship between the intestinal microbiota and metabolic phenotypes in rats with IgAN. Elucidation of the intestinal microbiota composition and metabolic signature alterations could identify predictive biomarkers for disease diagnosis and progression, which might contribute to providing therapeutic strategies for IgAN.

Enzymuria as a Marker of Renal Injury and Disease

PEDIATRICS ◽  
1979 ◽  
Vol 64 (1) ◽  
pp. 118-119
Author(s):  
Kumudchandra J. Sheth ◽  
Thomas A. Good
Keyword(s):  
Renal Disease ◽  
Renal Injury ◽  
Renal Damage ◽  
Upright Posture ◽  
Orthostatic Proteinuria

We concur with the comments made by Dr. Kunin and colleagues in their article on N-acetyl-β-glucosaminidase (NAG) as a marker of renal injury (Pediatrics 62:751, 1978). Despite a correlation between enzymuria and proteinuria in Figure 6, we feel that both proteinuria and enzymuria reflect the underlying renal damage. In addition to NAG, we also studied three other urinary lysosomal acidic hydrolases—β-galactosidase, α-fucosidase, and arylsulfatase—in children with renal disease.1 In three children with orthostatic proteinuria, despite increased proteinuria in upright posture, enzymuria remained normal both in recumbent and upright posture.1

scholarly journals Nephroprotective in patients with metabolic syndrome: approaches to the appointment of antihypertensive drugs

2016 ◽  
Vol 13 (2) ◽  
pp. 77-83
Author(s):  
O D Ostroumova ◽  
A A Zykova ◽  
M L Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
Arterial Hypertension ◽  
Renal Damage ◽  
Antihypertensive Drugs ◽  
Prognostic Significance ◽  
Mechanisms Of Development ◽  
Selection Of

In the article shows the questions of prevalence, diagnosis and prognostic significance of renal damage in metabolic syndrome. Discusses the pathogenetic mechanisms of development and progression of chronic kidney disease in individuals with obesity. Approaches to selection of antihypertensive drugs, advantages and limitations of the major classes of antihypertensive drugs in the treatment of metabolic syndrome, arterial hypertension combined with renal disease.

scholarly journals Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age

2018 ◽  
Vol 29 (12) ◽  
pp. 2835-2846 ◽  
Author(s):  
Wenling Zheng ◽  
Jianjun Mu ◽  
Chao Chu ◽  
Jiawen Hu ◽  
Yu Yan ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Disease ◽  
Early Life ◽  
Renal Damage ◽  
Middle Age ◽  
Later Life ◽  
Stable Group ◽  
Factors Affecting ◽  
Group A

BackgroundAlthough high BP is one of the most important factors affecting renal function, whether longitudinal BP trajectories in early life course are associated with renal function damage in later life is unclear.MethodsTo investigate the correlation between BP trajectories from childhood to adulthood and renal function in middle age, we used group-based trajectory models to identify BP trajectories in 2430 individuals (aged 6–15 years old at baseline) participating in the ongoing Hanzhong Adolescent Hypertension Cohort. We tested the association between these trajectories and subclinical renal damage in middle age, adjusting for several covariates.ResultsWe identified four distinct systolic BP trajectories among 2430 subjects: low stable, moderate stable, high stable, and moderate increasing on the basis of systolic BP levels at baseline and during the 30-year follow-up period. The urinary albumin-to-creatinine ratio (uACR) was higher in moderate stable, high stable, and moderate increasing groups compared with the low stable group. A total of 228 individuals had subclinical renal disease by 2017. Compared with the low stable trajectory group, the other groups had increasingly greater odds of experiencing subclinical renal disease in middle age. These associations were not altered after adjustment for other covariates, except for in the moderate stable group. Analyzed results were similar for the mean arterial pressure and diastolic BP trajectory groups.ConclusionsHigher BP trajectories were correlated with higher of uACR levels and risk of subclinical renal disease in middle age. Identifying long-term BP trajectories from early age may assist in predicting individuals’ renal function in later life.

Scanning Electron Microscopy of the glomerulus in diabetic BB/S wistar rats

1987 ◽  
Vol 45 ◽  
pp. 730-731
Author(s):  
R. C. Kaufmann ◽  
F. K. Khosho ◽  
K. S. Amankwah
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Glucose Tolerance ◽  
Renal Disease ◽  
Wistar Rats ◽  
Renal Damage ◽  
Diabetic Rats ◽  
Wistar Strain ◽  
Glucose Tolerance Tests ◽  
Scanning Electron

Renal damage secondary to diabetes seems to be related to the severity and duration of the diabetes. In streptozotocin and alloxan-induced diabetic rats, renal disease is found only in those rats that have glycosuria and then only after the glycosuria has been present for many months. In these animals, the longer they have glycosuria, the more severe the renal damage. In our colony of BB/S Wistar rats, animals that are going. to become frankly diabetic demonstrate clinical diabetes before they begin spilling glucose in their urine. After glycosuria develops, the condition of the animals worsens; yet, the glucose tolerance tests(GTT) remain essentially unchanged. The purpose of this investigation was to study the animals' kidneys to discover if lesions are present at the onset of glycosuria and how severe the lesions are.Rats of our BB/S Wistar strain were used the day they developed glycosuria. Similarly aged non-diabetic animals were used as controls.

Personality factors in analgesic nephropathy

1974 ◽  
Vol 4 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Robin M. Murray
Keyword(s):  
Renal Impairment ◽  
Renal Disease ◽  
Personality Traits ◽  
Renal Damage ◽  
Personality Inventory ◽  
Personality Factors ◽  
Analgesic Nephropathy ◽  
Eysenck Personality Inventory

SYNOPSISForty-five patients with analgesic nephropathy showed a trend towards introversion and neuroticism on the Eysenck Personality Inventory. Other analgesic abusers without renal impairment also showed these traits, while controls with renal disease not due to analgesie abuse were significantly less introverted and neurotic. It is suggested that these personality traits predisposed the patients to analgesie abuse and therefore to renal damage.

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