Kiwifruit (Actinidia deliciosa), compared with cellulose and psyllium, influences the histology and mucus layer of the gastrointestinal tract in the growing pig

2021 ◽  
Author(s):  
Carlos Montoya ◽  
SJ Henare ◽  
Erin M O'Donoghue ◽  
Doug Rosendale ◽  
Patrick Edwards ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Actinidia Deliciosa ◽  
Mucus Layer ◽  
Growing Pig ◽  
Mucosal Changes

Kiwifruit (KF) fiber, a mixture of soluble and insoluble fibers, elicits mucosal changes in the gastrointestinal tract (GIT). This study aimed to define the nature of these changes in mucosal...

scholarly journals Intestinal Mucus Layer and Mucins (A Review)

2016 ◽  
Vol 60 (1) ◽  
pp. 21-25 ◽  
Author(s):  
L. Tarabova ◽  
Z. Makova ◽  
E. Piesova ◽  
R. Szaboova ◽  
Z. Faixova
Keyword(s):  
Gastrointestinal Tract ◽  
Mucus Layer ◽  
Surface Areas ◽  
Intestinal Mucus ◽  
Mucosal Tissues ◽  
Gel Layer ◽  
Loss Of Weight ◽  
Different Types ◽  
And Function

AbstractThe gastrointestinal tract, like the urinary, respiratory, reproductive tracts and the surface of the eye, has large surface areas which are in contact with the exterior environment. The mucosal tissues in the gastrointestinal tract are exposed to large number of exogenous, water or food born microbiota. Therefore, they serve as access routes for different types of bacteria, parasites, viruses, enzymes and toxins. In order to protect the mucosal tissues against pathogens and aggressive enzymes, which are necessary in digestive processes, they are covered by a resident microbial flora and also by a viscoelastic adherent mucous gel layer. The mucus layer acts as the first line of defense against threats and also as a positive environment for beneficial endogenous microbiota adapted for symbiotic living. The quantity and quality of mucus layers varies throughout the gastrointestinal tube and is often changed and disrupted during the occurrence disease. A disturbed mucus layer in the intestine can result in changes in the whole organism, such as: impaired immunity, loss of weight and weak food conversion, which is important, especially in food animals. That is why several researchers have focused on these changes, both in humans and other animals, to find out methods and countermeasures, which will facilitate the best protection for the mucus layer in the intestine. In this review, we describe the composition and function of the mucus layer and mucins in the intestine.

scholarly journals Special Issue: Gut Bacteria-Mucus Interaction

2019 ◽  
Vol 7 (1) ◽  
pp. 6 ◽  
Author(s):  
Nathalie Juge
Keyword(s):  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Critical Role ◽  
Gut Bacteria ◽  
Mucus Layer ◽  
Special Issue

The mucus layer covering the gastrointestinal tract plays a critical role in maintaining a homeostatic relationship with our gut microbiota. [...]

Ileal and hindgut fermentation in the growing pig fed a human-type diet

2020 ◽  
Vol 124 (6) ◽  
pp. 567-576 ◽  
Author(s):  
Anna M. E. Hoogeveen ◽  
Paul J. Moughan ◽  
Edward S. de Haas ◽  
Paul Blatchford ◽  
Warren C. McNabb ◽  
...  
Keyword(s):  
Body Weight ◽  
Organic Matter ◽  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Taxonomic Composition ◽  
Human Type ◽  
Growing Pig ◽  
Microbial Inocula

AbstractDietary fibre fermentation in humans and monogastric animals is considered to occur in the hindgut, but it may also occur in the lower small intestine. This study aimed to compare ileal and hindgut fermentation in the growing pig fed a human-type diet using a combined in vivo/in vitro methodology. Five pigs (23 (sd 1·6) kg body weight) were fed a human-type diet. On day 15, pigs were euthanised. Digesta from terminal jejunum and terminal ileum were collected as substrates for fermentation. Ileal and caecal digesta were collected for preparing microbial inocula. Terminal jejunal digesta were fermented in vitro with a pooled ileal digesta inoculum for 2 h, whereas terminal ileal digesta were fermented in vitro with a pooled caecal digesta inoculum for 24 h. The ileal organic matter fermentability (28 %) was not different from hindgut fermentation (35 %). However, the organic matter fermented was 66 % greater for ileal fermentation than hindgut fermentation (P = 0·04). Total numbers of bacteria in ileal and caecal digesta did not differ (P = 0·09). Differences (P < 0·05) were observed in the taxonomic composition. For instance, ileal digesta contained 32-fold greater number of the genus Enterococcus, whereas caecal digesta had a 227-fold greater number of the genus Ruminococcus. Acetate synthesis and iso-valerate synthesis were greater (P < 0·05) for ileal fermentation than hindgut fermentation, but propionate, butyrate and valerate synthesis was lower. SCFA were absorbed in the gastrointestinal tract location where they were synthesised. In conclusion, a quantitatively important degree of fermentation occurs in the ileum of the growing pig fed a human-type diet.

scholarly journals Mucispirillum schaedleri gen. nov., sp. nov., a spiral-shaped bacterium colonizing the mucus layer of the gastrointestinal tract of laboratory rodents

2005 ◽  
Vol 55 (3) ◽  
pp. 1199-1204 ◽  
Author(s):  
Bronwyn R. Robertson ◽  
Jani L. O'Rourke ◽  
Brett A. Neilan ◽  
Peter Vandamme ◽  
Stephen L. W. On ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
New Genus ◽  
Bacterial Species ◽  
Mucus Layer ◽  
Bacterial Isolates ◽  
New Genus And Species ◽  
Laboratory Rodents ◽  
Distinct Lineage ◽  
High Level

The mammalian gastrointestinal tract is covered by a layer of mucus that can harbour a range of bacterial species specifically adapted to colonize this ecological niche. Examination of 110 bacterial isolates cultivated from the gastrointestinal tract of 23 mice revealed the presence of a subgroup of 30 isolates that did not correspond genetically with genera commonly associated with this site, i.e. members of the ε-Proteobacteria such as Helicobacter and Campylobacter species. Instead this group of isolates was found to lie within the phylum Deferribacteres, a completely distinct lineage in the domain Bacteria. There was a high level of consensus in results obtained from the phenotypic and genotypic characterization of a number of the isolates, which showed they were distinct from other members of the Deferribacteres. As such, they are proposed to constitute a new genus and species, Mucispirillum schaedleri gen. nov., sp. nov. These organisms are anaerobic, Gram-negative, spiral-shaped rods with bipolar flagella. The type strain is HRI I17T (=ATCC BAA-1009T=ACM 5223T).

Mucosal changes in the upper gastrointestinal tract in patients with hemorrhagic fever with renal syndrome and leptospirosis

2020 ◽  
Vol 2_2020 ◽  
pp. 50-55
Author(s):  
Klochkov I.N. Klochkov ◽  
Martynov V.A. Martynov ◽  
Zhdanovich L.G. Zhdanovich ◽  
Karaseva E.A. Karaseva E ◽  
Keyword(s):  
Gastrointestinal Tract ◽  
Hemorrhagic Fever ◽  
Upper Gastrointestinal Tract ◽  
Mucosal Changes ◽  
Upper Gastrointestinal

scholarly journals Characterization of urea transport mechanisms in the intestinal tract of growing pigs

2019 ◽  
Vol 317 (6) ◽  
pp. G839-G844 ◽  
Author(s):  
Jack E. C. Krone ◽  
Atta K. Agyekum ◽  
Miriam ter Borgh ◽  
Kimberley Hamonic ◽  
Gregory B. Penner ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Intestinal Tract ◽  
Growing Pigs ◽  
Urea Transport ◽  
Urea Transporter ◽  
Tissue Samples ◽  
Ussing Chambers ◽  
Relative Contribution ◽  
Growing Pig ◽  
Urea Recycling

Pigs are capable of nitrogen salvage via urea recycling, which involves the movement of urea in the gastrointestinal tract. Aquaporins (AQP) and urea transporter B (UT-B) are involved in urea recycling in ruminants; however, their contribution to urea flux in the intestinal tract of the pig is not known. The objective of this study was to characterize the presence and relative contribution of known urea transporters to urea flux in the growing pig. Intestinal tissue samples (duodenum, jejunum, ileum, cecum, and colon) were obtained from nine barrows (50.8 ± 0.9 kg) and analyzed for mRNA abundance of UT-B and AQP-3, -7, and -10. Immediately after tissue collection, samples from the jejunum and cecum were placed in Ussing chambers for analysis of the serosal-to-mucosal urea flux ( Jsm-urea) with no inhibition or when incubated in the presence of phloretin to inhibit UT-B-mediated transport, NiCl2 to inhibit AQP-mediated transport, or both inhibitors. UT-B expression was greatest ( P < 0.05) in the cecum, whereas AQP-3, -7, and -10 expression was greatest ( P < 0.05) in the jejunum. The Jsm-urea was greater in the cecum than the jejunum (67.8 . 42.7 ± 5.01 µmol·cm−2·h−1; P < 0.05), confirming the capacity for urea recycling in the gut in pigs; however, flux rate was not influenced ( P > 0.05) by urea transporter inhibitors. The results of this study suggest that, although known urea transporters are expressed in the gastrointestinal tract of pigs, they may not play a significant functional role in transepithelial urea transport. NEW & NOTEWORTHY We characterized the location and contribution of known urea transporters to urea flux in the pig. Aquaporins are located throughout the intestinal tract, and urea transporter B is expressed only in the cecum. Urea flux occurred in both the jejunum and cecum. Transporter inhibitors had no affect on urea flux, suggesting that their contribution to urea transport in the intestinal tract is limited. Further work is required to determine which factors contribute to urea flux in swine.

scholarly journals Effects of guar gum on plasma urea, insulin and glucose in the growing pig

1989 ◽  
Vol 61 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Kjell MalmlÖf ◽  
Carlos Simoes Nunes ◽  
Stefan Askbrant
Keyword(s):  
Gastrointestinal Tract ◽  
Test Meal ◽  
Guar Gum ◽  
Basal Diet ◽  
Growing Pigs ◽  
Plasma Urea ◽  
Blood Samples ◽  
Arterial Blood ◽  
Time Period ◽  
Growing Pig

1. Six growing pigs fitted with portal and arterial blood cannulas were given a barley-fishmeal diet, either alone or supplemented with guar gum at 60 g/kg basal diet. Blood samples were taken during 8 h following test meals given at 08.00 hours.2. Ingestion of the guar-gum-supplemented diet appeared to increase systematically portal and arterial levels of plasma urea. At peak values, 4 and 5 h after the test meal, this effect was statistically significant (P <0.05).3. Irrespective of which diet was given, portal and arterial blood samples, withdrawn at the same time, were found to have about the same concentration of urea. This was found throughout the 8 h studied and implies that no net exchange of urea between the circulation and the gastrointestinal tract, as a whole, took place.4. In the time-period 30–60 min following the test meal, guar gum significantly reduced the postprandial hyperglycaemia and hyperinsulinaemia in portal blood.

scholarly journals Mucus barrier, mucins and gut microbiota: the expected slimy partners?

Gut ◽  
2020 ◽  
Vol 69 (12) ◽  
pp. 2232-2243 ◽  
Author(s):  
Paola Paone ◽  
Patrice D Cani
Keyword(s):  
Gastrointestinal Tract ◽  
Dietary Habits ◽  
Food Additives ◽  
The Body ◽  
Mucus Layer ◽  
Gut Barrier ◽  
Fibre Diet ◽  
Regulation Of Synthesis ◽  
Mucus Barrier

The gastrointestinal tract is often considered as a key organ involved in the digestion of food and providing nutrients to the body for proper maintenance. However, this system is composed of organs that are extremely complex. Among the different parts, the intestine is viewed as an incredible surface of contact with the environment and is colonised by hundreds of trillions of gut microbes. The role of the gut barrier has been studied for decades, but the exact mechanisms involved in the protection of the gut barrier are various and complementary. Among them, the integrity of the mucus barrier is one of the first lines of protection of the gastrointestinal tract. In the past, this ‘slimy’ partner was mostly considered a simple lubricant for facilitating the progression of the food bolus and the stools in the gut. Since then, different researchers have made important progress, and currently, the regulation of this mucus barrier is gaining increasing attention from the scientific community. Among the factors influencing the mucus barrier, the microbiome plays a major role in driving mucus changes. Additionally, our dietary habits (ie, high-fat diet, low-fibre/high-fibre diet, food additives, pre- probiotics) influence the mucus at different levels. Given that the mucus layer has been linked with the appearance of diseases, proper knowledge is highly warranted. Here, we debate different aspects of the mucus layer by focusing on its chemical composition, regulation of synthesis and degradation by the microbiota as well as some characteristics of the mucus layer in both physiological and pathological situations.

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