A multifunctional ingredient for the management of metabolic syndrome in cafeteria diet-fed rats

2021 ◽  
Author(s):  
Miguel Z. Martín-González ◽  
Héctor Palacios-Jordan ◽  
Anna Mas-Capdevila ◽  
Miguel A. Rodríguez ◽  
Francisca I. Bravo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cafeteria Diet ◽  
Lipid Homeostasis ◽  
Obese Rats ◽  
Glucose And Lipid Homeostasis ◽  
Antihypertensive Properties

A novel dietary multifunctional ingredient improves glucose and lipid homeostasis and exhibits antihypertensive properties in cafeteria-fed obese rats.

scholarly journals PATHOPHYSIOLOGICAL CHANGES IN LIVER TISSUES OF HYPERCALORIE DIET-INDUCED OBESE RATS

2016 ◽  
Vol 10 (1) ◽  
pp. 338 ◽  
Author(s):  
Bharatha Ambadasu ◽  
Ramadevi S ◽  
Naikawadi Aa ◽  
Naveen Kumar M
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Cafeteria Diet ◽  
Nonalcoholic Fatty Liver ◽  
Obese Rats ◽  
Diet Intake ◽  
Liver Tissues

ABSTRACTObjectives: Hypercalorie diet intake has been associated with many long-term complications including metabolic syndrome, cardiovascular diseases,and nonalcoholic fatty liver disease.Methods: A total of 12 Wistar rats either sex were used in this study. These animals were randomly divided into two groups as control and obese rats.Group 1 consists of six rats weighing 150-200 g and fed with normal pellet chow. Another six rats were fed hypercalorie/cafeteria diet to induce obesity andincluded in the study after 19 weeks of age. All animals were sacrificed; liver tissues were collected, weighed and sent for the histopathological examination.Results: Weight of liver tissues of was significantly more in obese rats than the control rats. Histopathological examination shows an excessive fatdeposition and sinusoidal congestion in the liver tissues of obese rats.Conclusion: Increase in body weight is associated with the increase in fat deposition in the liver tissues which further develops into inflammationand necrosis of liver cells.Keywords: Wistar rats, Hypercalorie/cafeteria diet, Obese rats, Histopathological examination.

scholarly journals Are Zucker obese rats a useful model for cardiovascular complications in metabolic syndrome? Physical, biochemical and oxidative stress considerations

2009 ◽  
Vol 23 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Régine Debin ◽  
Benjamin Lauzier ◽  
Pierre Sicard ◽  
Stéphanie Delemasure ◽  
Sébastien Amoureux ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Cardiovascular Complications ◽  
Obese Rats ◽  
And Oxidative Stress

205-LB: HGFAC Is a ChREBP-Regulated Hepatokine That Enhances Glucose and Lipid Homeostasis

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 205-LB
Author(s):  
ASHOT SARGSYAN ◽  
LUDIVINE DORIDOT ◽  
SARAH A. HANNOU ◽  
WENXIN TONG ◽  
HARINI SRINIVASAN ◽  
...  
Keyword(s):  
Lipid Homeostasis ◽  
Glucose And Lipid Homeostasis

scholarly journals The Effects of Naphthenic Acids on Tryptophan Metabolism and Peripheral Serotonin Signalling

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A493-A493
Author(s):  
Laiba Jamshed ◽  
Genevieve A Perono ◽  
Shanza Jamshed ◽  
Kim Ann Cheung ◽  
Philippe J Thomas ◽  
...  
Keyword(s):  
Oil Sands ◽  
Naphthenic Acid ◽  
Kynurenine Pathway ◽  
Naphthenic Acids ◽  
Tryptophan Metabolism ◽  
Lipid Homeostasis ◽  
Prostaglandin E ◽  
Serotonin Synthesis ◽  
Active Metabolites ◽  
Glucose And Lipid Homeostasis

Abstract Introduction: Serotonin produced in the periphery has been shown to affect glucose and lipid homeostasis. The availability of the amino acid tryptophan, the precursor of serotonin, affects serotonin availability. In addition, the metabolism of tryptophan via the kynurenine pathway produces physiologically active metabolites which have been shown to be altered under conditions of increased adiposity and dysglycemia. There is now evidence demonstrating some environmental xenobiotics, known to affect glucose and lipid homeostasis, can also alter serotonin production and key components of the kynurenine pathway. Recent evidence suggests that exposure to compounds present in petroleum and wastewaters from oil and gas extraction sites can impact endocrine signaling and result in aberrant lipid accumulation and altered glycemic control. However, whether any of these changes can be causally ascribed to altered serotonin synthesis/signaling or tryptophan metabolism remains unknown. The goal of this study was to determine the effects of exposure to naphthenic acid (NA), a key toxicant found in wastewater from bitumen (thick crude oil present in oil sands deposits) extraction on the enzymes involved in tryptophan metabolism and serotonin production. Methods: McA-RH7777 rat hepatoma cells, were exposed to a technical NA mixture for 48 hours at concentrations within the reported range of NA found in wastewaters from oil extraction. We assessed mRNA expression for key rate-limiting enzymes involved in tryptophan metabolism that lead to either serotonin [Tph1] and/or kynurenine [Ido2 and Tdo2] production, as well as downstream enzymes in the kynurenine pathway [Afmid, Kyat1, Aadat, Kyat3, Kmo, Haao, Acmsd, Qprt]. We also examined the effects of NA on prostaglandin synthesis [Ptgs1, Ptgs2, Ptges] and signalling [Ptger2, Ptger4] as prostaglandins have been shown to be induced by serotonin and are linked to hepatic fat accumulation. Results: NA treatment significantly increased Tph1 and Ido2 expression; this occurred in association with a significant increase in the expression of the inducible prostaglandin synthase Ptgs2 (COX-2), prostaglandin E synthase Ptges, and prostaglandin receptors Ptger2 and Ptger4. Acmsd was the only downstream enzyme in the kynurenine pathway that was significantly altered by NA treatment. Conclusion: These results provide proof-of-concept that compounds associated with oil sands extraction have the potential to perturb key components of serotonin synthesis (Tph1) and tryptophan metabolism (Ido2, Acmsd). Furthermore, we found that the increase in Tph1 expression paralleled expression of Ptgs2. As increased prostaglandin production has been reported in association with nonalcoholic steatohepatitis, these data provide a potential mechanism by which exposure to NA and other petroleum-based compounds may increase the risk of metabolic disease.

scholarly journals Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis

JCI Insight ◽  
2021 ◽  
Vol 6 (10) ◽  
Author(s):  
Shanu Jain ◽  
Sai P. Pydi ◽  
Young-Hwan Jung ◽  
Mirko Scortichini ◽  
Efrat L. Kesner ◽  
...  
Keyword(s):  
Whole Body ◽  
Lipid Homeostasis ◽  
Glucose And Lipid Homeostasis

scholarly journals The Effect of Combined Diet Containing n-3 Polyunsaturated Fatty Acids and Silymarin on Metabolic Syndrome in Rats

2019 ◽  
pp. S39-S50
Author(s):  
M. PORUBA ◽  
P. ANZENBACHER ◽  
Z. RACOVA ◽  
O. OLIYARNYK ◽  
M. HÜTTL ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Metabolic Disorders ◽  
Male Rats ◽  
Lipid Homeostasis ◽  
Metabolic Disturbances ◽  
Serum Triglycerides ◽  
Esterified Fatty Acids

The risk of development of metabolic syndrome can be increased by hypertriglyceridemia. A search for effective therapy is a subject of considerable attention. Therefore, our hypothesis is that the fish oil (containing polyunsaturated fatty acids; n-3 PUFA) in a combination with silymarin can more effectively protect against hypertriglyceridemia-induced metabolic disturbances. The study was conducted using a unique non-obese strain of rats with hereditary hypertriglyceridemia an accepted model of metabolic syndrome. Adult male rats were treated with n-3 PUFA (300 mg/kg/day) without or with 1 % micronized silymarin in a diet for 4 weeks. The treatment with the diet containing n-3 PUFA and silymarin significantly reduced concentrations of serum triglycerides (-45 %), total cholesterol (-18 %), non-esterified fatty acids (-33 %), and ectopic lipid accumulation in skeletal muscle (-35 %) compared to controls. In addition, an increase in Abcg5 and Abcg8 mRNA expression (as genes affecting lipid homeostasis) as well as in protein content of ABCG5 (+78 %) and ABCG8 (+232 %) transporters have been determined in the liver of treated rats. Our findings suggest that this combined diet could be used in the prevention of hypertriglyceridemia-induced metabolic disorders.

Effects of Exogenous Intravenous Glucose on Plasma Glucose and Lipid Homeostasis in Anesthetized Children

1991 ◽  
Vol 74 (6) ◽  
pp. 1017-1022 ◽  
Author(s):  
Katsuya Mikawa ◽  
Nobuhiro Maekawa ◽  
Ryokichi Goto ◽  
Osamu Tanaka ◽  
Hideaki Yaku ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Lipid Homeostasis ◽  
Intravenous Glucose ◽  
Glucose And Lipid Homeostasis
Sign in / Sign up

Export Citation Format

Share Document