Citrus limonoids induce apoptosis and inhibit proliferation of pancreatic cancer cells

2021 ◽  
Author(s):  
Kotamballi N Chidambara Murthy ◽  
Guddadarangavvanahal Jayaprakasha ◽  
Bhimanagouda S. Patil ◽  
Stephen Safe
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells ◽  
Induced Apoptosis ◽  
Citrus Seeds

In our recent study, we have demonstrated certain limonoids isolated from citrus seeds have induced apoptosis in human pancreatic (Panc-28) cells. In the current study, limonin, nomilin and limonexic acid...

Panax Notoginseng Saponins Promote Cell Death and Chemosensitivity in Pancreatic Cancer through the Apoptosis and Autophagy Pathways

2020 ◽  
Vol 20 ◽  
Author(s):  
Li-Chao Yao ◽  
Lun Wu ◽  
Wei Wang ◽  
Lu-Lu Zhai ◽  
Lin Ye ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Panax Notoginseng ◽  
Panax Notoginseng Saponins ◽  
Transwell Assay ◽  
Pancreatic Cancer Cells ◽  
New Strategy ◽  
Induced Apoptosis ◽  
Promote Cell Death

Background:: Panax Notoginseng Saponins (PNS) is used as traditional Chinese medicine for ischemic stroke and cardiovascular disease, it has been proven to possess anticancer activity recently. Objective:: In this study, we aimed to explore the anticancer curative effect and potential mechanisms of PNS in pancreatic cancer cells. Methods:: Pancreatic cancer Miapaca2 and PANC-1 cells were treated with PNS and Gemcitabine (Gem), respectively. Then the cell viability was assessed by CCK-8 assay, cell proliferation was tested by colony formation assay and EdU cell proliferation assay, cell migration and invasiveness were tested by wound healing assay and transwell assay respectively, and cell apoptosis was detected by flow cytometry. Finally, we detected the expression levels of proteins related to migration, apoptosis and autophagy through Western blotting. Results:: PNS not only inhibited the proliferation, migration, invasion and autophagy of Miapaca2 and PANC-1 cells, but also induced apoptosis and promoted chemosensitivity of pancreatic cancer cells to Gem. Conclusion:: PNS may exhibit cytotoxicity and increase chemosensitivity of pancreatic cancer cells to Gem by inhibiting autophagy and inducing apoptosis, providing a new strategy and potential treatment option for pancreatic cancer.

scholarly journals Beclin1 inhibition promotes autophagy and decreases gemcitabine–induced apoptosis in Miapaca2 pancreatic cancer cells

2013 ◽  
Vol 13 (1) ◽  
pp. 26 ◽  
Author(s):  
Xiaoshu Li ◽  
Jun Yan ◽  
Lisheng Wang ◽  
Fengjun Xiao ◽  
Yuefeng Yang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells ◽  
Induced Apoptosis

scholarly journals Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41102 ◽  
Author(s):  
Shadi Mamaghani ◽  
Craig D. Simpson ◽  
Pinjiang M. Cao ◽  
May Cheung ◽  
Sue Chow ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Pancreatic Cancer Cells ◽  
Induced Apoptosis
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