The phytochemistry and pharmacology of medicinal fungi of the genus Phellinus: a review

2021 ◽  
Author(s):  
Pingya He ◽  
Yi Zhang ◽  
Ning Li
Keyword(s):  
Secondary Metabolites ◽  
Comprehensive Review ◽  
Medicinal Fungi

A comprehensive review on secondary metabolites with bioactivities from 13 Phellinus species.

scholarly journals MeFSAT: a curated natural product database specific to secondary metabolites of medicinal fungi

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2596-2607
Author(s):  
R. P. Vivek-Ananth ◽  
Ajaya Kumar Sahoo ◽  
Kavyaa Kumaravel ◽  
Karthikeyan Mohanraj ◽  
Areejit Samal
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Natural Product ◽  
Chemical Space ◽  
Therapeutic Uses ◽  
Medicinal Fungi ◽  
Fungal Natural Products

First dedicated manually curated resource on secondary metabolites and therapeutic uses of medicinal fungi. Cheminformatics based analysis of the chemical space of fungal natural products.

scholarly journals Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant Species: A Comprehensive Review

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4146
Author(s):  
Javad Mottaghipisheh ◽  
Marcello Iriti
Keyword(s):  
Phenolic Compounds ◽  
Secondary Metabolites ◽  
Plant Species ◽  
Health Benefits ◽  
Significant Information ◽  
Comprehensive Review ◽  
Isolation And Purification ◽  
Phytochemical Investigation ◽  
Plant Families ◽  
Pure Methanol

Flavonoids are considered one of the most diverse phenolic compounds possessing several valuable health benefits. The present study aimed at gathering all correlated reports, in which Sephadex® LH-20 (SLH) has been utilized as the final step to isolate or purify of flavonoid derivatives among all plant families. Overall, 189 flavonoids have been documented, while the majority were identified from the Asteraceae, Moraceae, and Poaceae families. Application of SLH has led to isolate 79 flavonols, 63 flavones, and 18 flavanones. Homoisoflavanoids, and proanthocyanidins have only been isolated from the Asparagaceae and Lauraceae families, respectively, while the Asteraceae was the richest in flavones possessing 22 derivatives. Six flavones, four flavonols, three homoisoflavonoids, one flavanone, a flavanol, and an isoflavanol have been isolated as the new secondary metabolites. This technique has been able to isolate quercetin from 19 plant species, along with its 31 derivatives. Pure methanol and in combination with water, chloroform, and dichloromethane have generally been used as eluents. This comprehensive review provides significant information regarding to remarkably use of SLH in isolation and purification of flavonoids from all the plant families; thus, it might be considered an appreciable guideline for further phytochemical investigation of these compounds.

scholarly journals MeFSAT: A curated natural product database specific to secondary metabolites of medicinal fungi

2020 ◽  
Author(s):  
R.P. Vivek-Ananth ◽  
Ajaya Kumar Sahoo ◽  
Kavyaa Kumaravel ◽  
Karthikeyan Mohanraj ◽  
Areejit Samal
Keyword(s):  
Secondary Metabolites ◽  
Physicochemical Properties ◽  
Natural Product ◽  
Chemical Space ◽  
Chemical Structures ◽  
Therapeutic Uses ◽  
Natural Product Library ◽  
Medicinal Fungi ◽  
Similarity Networks ◽  
Shape Complexity

AbstractFungi are a rich source of secondary metabolites which constitutes a valuable and diverse chemical space of natural products. Medicinal fungi have been used in traditional medicine to treat human ailments for centuries. To date, there is no devoted resource on secondary metabolites and therapeutic uses of medicinal fungi. Such a dedicated resource compiling dispersed information on medicinal fungi across published literature will facilitate ongoing efforts towards natural product based drug discovery. Here, we present the first comprehensive manually curated database on Medicinal Fungi Secondary metabolites And Therapeutics (MeFSAT) that compiles information on 184 medicinal fungi, 1830 secondary metabolites and 149 therapeutics uses. Importantly, MeFSAT contains a non-redundant in silico natural product library of 1830 secondary metabolites along with information on their chemical structures, computed physicochemical properties, drug-likeness properties, predicted ADMET properties, molecular descriptors and predicted human target proteins. By comparing the physicochemical properties of secondary metabolites in MeFSAT with other small molecules collections, we find that fungal secondary metabolites have high stereochemical complexity and shape complexity similar to other natural product libraries. Based on multiple scoring schemes, we have filtered a subset of 228 drug-like secondary metabolites in MeFSAT database. By constructing and analyzing chemical similarity networks, we show that the chemical space of secondary metabolites in MeFSAT is highly diverse. The compiled information in MeFSAT database is openly accessible at: https://cb.imsc.res.in/mefsat/.

scholarly journals Polyphenols: A Comprehensive Review of their Nutritional Properties

2021 ◽  
Vol 15 (1) ◽  
pp. 164-172
Author(s):  
Peyman Ebrahimi ◽  
Anna Lante
Keyword(s):  
Antioxidant Activity ◽  
Secondary Metabolites ◽  
Nutritional Value ◽  
Health Benefits ◽  
Natural Antioxidants ◽  
Natural Compounds ◽  
Nutritional Properties ◽  
Comprehensive Review ◽  
Nutritional Property ◽  
Disease Effect

Polyphenols are the most prominent natural antioxidants found numerously in nature. They are secondary metabolites recognized for having high health benefits for consumers, even if the exploitation of these remarkable natural compounds is still a challenge. Moreover, there is a dilemma over the nutritional value of polyphenols. Hence, this paper seeks to review the classification, sources, anti-browning effect, antioxidant activity, nutritional property and anti-disease effect of polyphenols for better understanding the issues which need to be addressed in the valorization of these natural compounds.

Medicinal fungi: a source of antiparasitic secondary metabolites

2018 ◽  
Vol 102 (14) ◽  
pp. 5791-5810 ◽  
Author(s):  
Juliana Lenzi ◽  
Tania Maria Costa ◽  
Michele Debiasi Alberton ◽  
Juliane Araújo Greinert Goulart ◽  
Lorena Benathar Ballod Tavares
Keyword(s):  
Secondary Metabolites ◽  
Medicinal Fungi

scholarly journals Endophytic Fungi from Terminalia Species: A Comprehensive Review

2019 ◽  
Vol 5 (2) ◽  
pp. 43 ◽  
Author(s):  
Rufin Marie Kouipou Toghueo ◽  
Fabrice Fekam Boyom
Keyword(s):  
Secondary Metabolites ◽  
Endophytic Fungi ◽  
Biological Activities ◽  
Fungal Endophytes ◽  
Structural Complexity ◽  
Chemical Diversity ◽  
Antioxidant Compounds ◽  
Comprehensive Review ◽  
Biological Potential ◽  
Insight Into

Endophytic fungi have proven their usefulness for drug discovery, as suggested by the structural complexity and chemical diversity of their secondary metabolites. The diversity and biological activities of endophytic fungi from the Terminalia species have been reported. Therefore, we set out to discuss the influence of seasons, locations, and even the plant species on the diversity of endophytic fungi, as well as their biological activities and secondary metabolites isolated from potent strains. Our investigation reveals that among the 200–250 Terminalia species reported, only thirteen species have been studied so far for their endophytic fungi content. Overall, more than 47 fungi genera have been reported from the Terminalia species, and metabolites produced by some of these fungi exhibited diverse biological activities including antimicrobial, antioxidant, antimalarial, anti-inflammatory, anti-hypercholesterolemic, anticancer, and biocontrol varieties. Moreover, more than 40 compounds with eighteen newly described secondary metabolites were reported; among these, metabolites are the well-known anticancer drugs, a group that includes taxol, antioxidant compounds, isopestacin, and pestacin. This summary of data illustrates the considerable diversity and biological potential of fungal endophytes of the Terminalia species and gives insight into important findings while paving the way for future investigations.

scholarly journals A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery

Metabolites ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 258 ◽  
Author(s):  
Uttpal Anand ◽  
Nadia Jacobo-Herrera ◽  
Ammar Altemimi ◽  
Naoufal Lakhssassi
Keyword(s):  
Multidrug Resistance ◽  
Drug Discovery ◽  
Antimicrobial Resistance ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Comprehensive Review ◽  
Rich Diversity ◽  
Potential Benefits ◽  
Wonder Drug ◽  
Novel Antibiotics

The war on multidrug resistance (MDR) has resulted in the greatest loss to the world’s economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a central role in treating infectious diseases. However, the inappropriate, irregular, and irrational uses of antibiotics have resulted in the emergence of antimicrobial resistance. This has resulted in an increased interest in medicinal plants since 30–50% of current pharmaceuticals and nutraceuticals are plant-derived. The question we address in this review is whether plants, which produce a rich diversity of secondary metabolites, may provide novel antibiotics to tackle MDR microbes and novel chemosensitizers to reclaim currently used antibiotics that have been rendered ineffective by the MDR microbes. Plants synthesize secondary metabolites and phytochemicals and have great potential to act as therapeutics. The main focus of this mini-review is to highlight the potential benefits of plant derived multiple compounds and the importance of phytochemicals for the development of biocompatible therapeutics. In addition, this review focuses on the diverse effects and efficacy of herbal compounds in controlling the development of MDR in microbes and hopes to inspire research into unexplored plants with a view to identify novel antibiotics for global health benefits.

scholarly journals Biomedical Effects of Popular Phytonutrients and Their Phytochemicals: A Comprehensive Review

2021 ◽  
Author(s):  
Yamixa Delgado ◽  
Céline Cassé ◽  
Yancy Ferrer-Acosta ◽  
Ivette J. Suárez-Arroyo ◽  
José Rodríguez-Zayas ◽  
...  
Keyword(s):  
Health Care ◽  
Immune Response ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Therapeutic Effects ◽  
Primary Metabolites ◽  
Comprehensive Review ◽  
Plant Foods

Phytonutrients are plant foods that contain many natural bioactive compounds, called phytochemicals, which expose specific biological activities. These phytonutrients and their phytochemicals may play an important role in health care maintaining normal organism functions (as preventives) and fighting against diseases (as therapeutics). Phytonutrient’s components are the primary metabolites (i.e., proteins, carbohydrates, and lipids) and phytochemicals or secondary metabolites (i.e., phenolics, alkaloids, organosulfides, and terpenes). For years, several phytonutrients and their phytochemicals have demonstrated specific pharmacological and therapeutic effects in human health such as anticancer, antioxidant, antiviral, anti-inflammatory, antibacterial, antifungal, and immune response. This review summarizes the effects of the most studied or the most popular phytonutrients (i.e., turmeric, garlic, cinnamon, graviola, and oregano), and any contraindication found. This article also calculated the physicochemical properties of the main phytochemicals in the selected phytonutrients using Lipinski’s, Veber’s and Ghose’s rules. Based on our revisions for this article, all these phytonutrients have consistently shown several in vitro, in vivo, and clinical studies with great potential as preventives and therapeutics on many diseases.

Oxyprenylated Secondary Metabolites as Modulators of Lipid and Sugar Metabolism

2021 ◽  
Vol 21 ◽  
Author(s):  
Serena Fiorito ◽  
Francesco Epifano ◽  
Lorenzo Marchetti ◽  
Lucia Palumbo ◽  
Ilkay Erdogan Orhan ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Metabolic Disorders ◽  
Sugar Metabolism ◽  
Review Article ◽  
Food Plants ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Beneficial Effects ◽  
Related Compounds

: O-Prenylcoumarins (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural compounds. The most part of these secondary metabolites have been obtained from plant species belonging to the Rutaceae, Apiaceae, andFabaceae families, and from fungi, and bacteria. In the last two decades prenyloxycoumarinshave been found to possess a great potential in terms of pharmacological activities. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about these valuable phytochemicals and structurally related compounds about their modulatory properties of lipid and sugar metabolism. Literature data have been acquired from the main Internet database. Several oxyprenylated secondary metabolites have been surveyed. Among these prenyloxycoumarins represented the main group exerting displayed valuable effects as modulators of lipid and sugar metabolism. The title phytochemicals have been found in common edible and fruits vegetables already known to have beneficial effects to this concern, thus enforcing the nutraceutical role of these food plants. All compounds outlined in the present review article have a great potential for the next future for the prevention and management of acute and chronic metabolic disorders

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