The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics analysis

2020 ◽  
Vol 11 (11) ◽  
pp. 9634-9650
Author(s):  
Jie Shen ◽  
Pei Li ◽  
Shuangshuang Liu ◽  
Qing Liu ◽  
Yue Li ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Rat Model ◽  
Aberrant Crypt Foci ◽  
Microbiota Composition ◽  
Omics Analysis ◽  
Gut Microbiota Composition

In the AOM-induced precancerous colorectal lesions rat model, HQT inhibits aberrant crypt foci formation mainly by modulating the gut microbiota composition and improving metabolomic disorders.

scholarly journals Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Morten Kobaek-Larsen ◽  
Dennis Sandris Nielsen ◽  
Witold Kot ◽  
Łukasz Krych ◽  
Lars Porskjær Christensen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
Rat Model ◽  
Microbiota Composition ◽  
Gut Microbiota Composition

scholarly journals Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4192
Author(s):  
Sara Nunes ◽  
Sofia D. Viana ◽  
Inês Preguiça ◽  
André Alves ◽  
Rosa Fernandes ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Rat Model ◽  
Molecular Mechanisms ◽  
Antioxidant Properties ◽  
Intestinal Barrier ◽  
Mitochondrial Bioenergetics ◽  
Microbiota Composition ◽  
Blueberry Juice ◽  
Hypercaloric Diet ◽  
Gut Microbiota Composition

The paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effects of BJ on glucose, insulin, and lipid profiles; gut microbiota composition; intestinal barrier integrity; and metabolic endotoxemia, as well as on hepatic metabolic surrogates, including several related to mitochondria bioenergetics. BJ supplementation for 14 weeks counteracted diet-evoked metabolic deregulation, improving glucose tolerance, insulin sensitivity, and hypertriglyceridemia, along with systemic and hepatic antioxidant properties, without a significant impact on the gut microbiota composition and related mechanisms. In addition, BJ treatment effectively alleviated hepatic steatosis and mitochondrial dysfunction observed in the prediabetic animals, as suggested by the amelioration of bioenergetics parameters and key targets of inflammation, insulin signaling, ketogenesis, and fatty acids oxidation. In conclusion, the beneficial metabolic impact of BJ in prediabetes may be mainly explained by the rescue of hepatic mitochondrial bioenergetics. These findings pave the way to support the use of BJ in prediabetes to prevent diabetes and its complications.

Changes in Human Gut Microbiota Composition Are Linked to the Energy Metabolic Switch During Ten Days of Fasting

2019 ◽  
Author(s):  
Robin Mesnage ◽  
Franziska Grundler ◽  
Andreas Schwiertz ◽  
Yvon Le Maho ◽  
Françoise Wilhelmi de Toledo
Keyword(s):  
Gut Microbiota ◽  
Microbiota Composition ◽  
Human Gut ◽  
Metabolic Switch ◽  
Human Gut Microbiota ◽  
Gut Microbiota Composition
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