Maternal diet with sea urchin gangliosides promotes neurodevelopment of young offspring via enhancing NGF and BDNF expression

2020 ◽  
Vol 11 (11) ◽  
pp. 9912-9923
Author(s):  
Xiaoxu Wang ◽  
Peixu Cong ◽  
Xincen Wang ◽  
Yanjun Liu ◽  
Lulu Wu ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Neuronal Differentiation ◽  
Sea Urchin ◽  
Maternal Diet ◽  
Bdnf Expression ◽  
Young Offspring

Sea urchin gangliosides are superior to GM1 and sialic acid in promoting neuronal differentiation and synapse function of postnatal 15-day mice, via up-regulating the expressions of BDNF and NGF.

Isolation, biochemical and immunological characterisation of two sea urchin glycoproteins bearing sulphated poly(sialic acid) polysaccharides rich in N-glycolyl neuraminic acid

Biochimie ◽  
1996 ◽  
Vol 78 (3) ◽  
pp. 171-182 ◽  
Author(s):  
N.K. Karamanos ◽  
A. Manouras ◽  
S. Anagnostides ◽  
E. Makatsori ◽  
T. Tsegenidis ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Sea Urchin ◽  
Neuraminic Acid

Olfactory Development, Part 1: Function, From Fetal Perception to Adult Wine-Tasting

2017 ◽  
Vol 32 (6) ◽  
pp. 566-578 ◽  
Author(s):  
Harvey B. Sarnat ◽  
Laura Flores-Sarnat ◽  
Xing-Chang Wei
Keyword(s):  
Olfactory Bulb ◽  
Amniotic Fluid ◽  
Neuronal Differentiation ◽  
Cranial Nerve ◽  
Metabolic Diseases ◽  
Maternal Diet ◽  
Sensory System ◽  
Olfactory Bulbs ◽  
Olfactory Development ◽  
Brain Malformations

Discrimination of odorous molecules in amniotic fluid occur after 30 weeks’ gestation; fetuses exhibit differential responses to maternal diet. Olfactory reflexes enable reliable neonatal testing. Olfactory bulbs can be demonstrated reliably by MRI after 30 weeks’ gestation, and their hypoplasia or aplasia also documented by late prenatal and postnatal MRI. Olfactory axons project from nasal epithelium to telencephalon before olfactory bulbs form. Fetal olfactory maturation remains incomplete at term for neuronal differentiation, synaptogenesis, myelination, and persistence of the transitory fetal ventricular recess. Immaturity does not signify nonfunction. Olfaction is the only sensory system without thalamic projection because of its own intrinsic thalamic equivalent. Diverse malformations of the olfactory bulb can be diagnosed by clinical examination, imaging, and neuropathology. Some epileptic auras might be primarily generated in the olfactory bulb. Cranial nerve 1 should be tested in all neonates and especially in patients with brain malformations, endocrinopathies, chromosomopathies, and genetic/metabolic diseases.

scholarly journals Identification of the Sea Urchin 350-kDa Sperm-binding Protein as a New Sialic Acid-binding Lectin That Belongs to the Heat Shock Protein 110 Family

2003 ◽  
Vol 278 (43) ◽  
pp. 42050-42057 ◽  
Author(s):  
Eri Maehashi ◽  
Chihiro Sato ◽  
Kaoru Ohta ◽  
Yoichiro Harada ◽  
Tsukasa Matsuda ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Sea Urchin ◽  
Binding Protein ◽  
Sperm Binding ◽  
Sialic Acid Binding ◽  
Binding Lectin

scholarly journals Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Salvatore Fusco ◽  
Matteo Spinelli ◽  
Sara Cocco ◽  
Cristian Ripoli ◽  
Alessia Mastrodonato ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Synaptic Plasticity ◽  
High Fat Diet ◽  
Metabolic Diseases ◽  
Brain Plasticity ◽  
Maternal Diet ◽  
Brain Health ◽  
High Fat ◽  
Bdnf Expression ◽  
Male Germline

Abstract Metabolic diseases harm brain health and cognitive functions, but whether maternal metabolic unbalance may affect brain plasticity of next generations is still unclear. Here, we demonstrate that maternal high fat diet (HFD)-dependent insulin resistance multigenerationally impairs synaptic plasticity, learning and memory. HFD downregulates BDNF and insulin signaling in maternal tissues and epigenetically inhibits BDNF expression in both germline and hippocampus of progeny. Notably, exposure of the HFD offspring to novel enriched environment restores Bdnf epigenetic activation in the male germline and counteracts the transmission of cognitive impairment to the next generations. BDNF administration to HFD-fed mothers or preserved insulin sensitivity in HFD-fed p66Shc KO mice also prevents the intergenerational transmission of brain damage to the progeny. Collectively, our data suggest that maternal diet multigenerationally impacts on descendants’ brain health via gametic mechanisms susceptible to lifestyle.

scholarly journals Sialic acid levels in breast milk from HIV-positive Tanzanian women and impact of maternal diet

AIDS ◽  
2019 ◽  
Vol 33 (3) ◽  
pp. 509-514
Author(s):  
Ruth I. Connor ◽  
Muhammad Zain-ul-Abideen ◽  
Albert K. Magohe ◽  
Elizabeth B. Brickley ◽  
Molly L. Housman ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Breast Milk ◽  
Maternal Diet ◽  
Hiv Positive

scholarly journals Sperm and Egg Jelly Coat from Sea Urchin Lytechinus variegatus Collected in Rio de Janeiro Contain Distinct Sialic Acid-Rich Polysaccharides

2015 ◽  
Vol 58 (4) ◽  
pp. 617-627 ◽  
Author(s):  
Gabrielle M. Valle ◽  
Leonardo P. Cinelli ◽  
Adriane R. Todeschini ◽  
Lycia de Brito-Gitirana ◽  
Ana-Cristina E.S. Vilela-Silva ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Sea Urchin ◽  
Rio De Janeiro ◽  
Lytechinus Variegatus ◽  
Jelly Coat ◽  
Egg Jelly
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