Morin as an imminent functional food ingredient: an update on its enhanced efficacy in the treatment and prevention of metabolic syndromes

2020 ◽  
Vol 11 (10) ◽  
pp. 8424-8443 ◽  
Author(s):  
Kiran Thakur ◽  
Yun-Yang Zhu ◽  
Jing-Yu Feng ◽  
Jian-Guo Zhang ◽  
Fei Hu ◽  
...  
Keyword(s):  
Brain Injury ◽  
Human Health ◽  
Functional Food ◽  
Therapeutic Agent ◽  
Protective Effects ◽  
Food Ingredient ◽  
Treatment And Prevention ◽  
Metabolic Syndromes

The sources, chemistry, functional potency, and protective effects of morin on metabolic syndromes ranging from cancer to brain injury were updated. As a whole, morin can be identified as a therapeutic agent for the expansion of human health.

scholarly journals Important Flavonoids and Their Role as a Therapeutic Agent

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5243
Author(s):  
Asad Ullah ◽  
Sidra Munir ◽  
Syed Lal Badshah ◽  
Noreen Khan ◽  
Lubna Ghani ◽  
...  
Keyword(s):  
Animal Models ◽  
Human Health ◽  
Recent Work ◽  
Mode Of Action ◽  
Therapeutic Agent ◽  
Biological Activities ◽  
Cost Effective ◽  
Protective Effects ◽  
Potential Applications ◽  
Phytochemical Compounds

Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.

Anthocyanins As Modulators of Cell Redox-Dependent Pathways in Non-Communicable Diseases

2020 ◽  
Vol 27 (12) ◽  
pp. 1955-1996 ◽  
Author(s):  
Antonio Speciale ◽  
Antonella Saija ◽  
Romina Bashllari ◽  
Maria Sofia Molonia ◽  
Claudia Muscarà ◽  
...  
Keyword(s):  
Human Health ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Antioxidant Defenses ◽  
Noncommunicable Diseases ◽  
Protective Effects ◽  
Pathological Conditions ◽  
Chronic Pulmonary Diseases ◽  
Underlying Mechanisms

: Chronic Noncommunicable Diseases (NCDs), mostly represented by cardiovascular diseases, diabetes, chronic pulmonary diseases, cancers, and several chronic pathologies, are one of the main causes of morbidity and mortality, and are mainly related to the occurrence of metabolic risk factors. Anthocyanins (ACNs) possess a wide spectrum of biological activities, such as anti-inflammatory, antioxidant, cardioprotective and chemopreventive properties, which are able to promote human health. Although ACNs present an apparent low bioavailability, their metabolites may play an important role in the in vivo protective effects observed. : This article directly addresses the scientific evidences supporting that ACNs could be useful to protect human population against several NCDs not only acting as antioxidant but through their capability to modulate cell redox-dependent signaling. In particular, ACNs interact with the NF-κB and AP-1 signal transduction pathways, which respond to oxidative signals and mediate a proinflammatory effect, and the Nrf2/ARE pathway and its regulated cytoprotective proteins (GST, NQO, HO-1, etc.), involved in both cellular antioxidant defenses and elimination/inactivation of toxic compounds, so countering the alterations caused by conditions of chemical/oxidative stress. In addition, supposed crosstalks could contribute to explain the protective effects of ACNs in different pathological conditions characterized by an altered balance among these pathways. Thus, this review underlines the importance of specific nutritional molecules for human health and focuses on the molecular targets and the underlying mechanisms of ACNs against various diseases.

scholarly journals Applicability of Honey on Silkworms (Bombyx mori) and Quality Improvement of Its Biomaterials

2021 ◽  
Vol 11 (10) ◽  
pp. 4613
Author(s):  
Gabriela-Maria Baci ◽  
Alexandra-Antonia Cucu ◽  
Adela Ramona Moise ◽  
Daniel Severus Dezmirean
Keyword(s):  
Quality Improvement ◽  
Bombyx Mori ◽  
Human Health ◽  
Recombinant Proteins ◽  
Therapeutic Agent ◽  
Life Sciences ◽  
Model Organism ◽  
Medical Field ◽  
Wide Range ◽  
Ancient Times

Since ancient times, honey has been considered one of the most illustrious and esteemed natural products. Honey plays two key roles; specifically, it is an appreciated nutritional product, and also exhibits a wide range of beneficial properties for human health as a therapeutic agent. Furthermore, it has been shown that honey has valuable effects on the biological and physiological features of mulberry silkworms (Bombyx mori). Bombyx mori exhibits importance not only for the economy, but it also serves as an important biotechnological bioreactor for the production of recombinant proteins that have a great impact in the medical field and beyond. It also represents an important model organism for life sciences. In view of the fact that silk fibroin serves as a natural biopolymer that displays high biocompatibility with human organisms and due to honey’s various and remarkable properties for human health, the two elements are currently used together in order to develop ideal biomaterials for a wide range of purposes. In this review, by discussing the applicability of honey on Bombyx mori and beyond, the importance of honey for life sciences and related fields is spotlighted.

scholarly journals Pinus Species as Prospective Reserves of Bioactive Compounds with Potential Use in Functional Food—Current State of Knowledge

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1306
Author(s):  
Marcin Dziedziński ◽  
Joanna Kobus-Cisowska ◽  
Barbara Stachowiak
Keyword(s):  
Human Health ◽  
Bioactive Compounds ◽  
Functional Food ◽  
Biological Activities ◽  
Food Ingredients ◽  
Beneficial Effects ◽  
Pine Tree ◽  
Pine Trees ◽  
Health Promoting ◽  
Few Data

The pine (Pinus L.) is the largest and most heteromorphic plant genus of the pine family (Pinaceae Lindl.), which grows almost exclusively in the northern hemisphere. The demand for plant-based remedies, supplements and functional food is growing worldwide. Although pine-based products are widely available in many parts of the world, they are almost absent as food ingredients. The literature shows the beneficial effects of pine preparations on human health. Despite the wide geographical distribution of pine trees in the natural environment, there are very few data in the literature on the widespread use of pine in food technology. This study aims to present, characterise and evaluate the content of phytochemicals in pine trees, including shoots, bark and conifer needles, as well as to summarise the available data on their health-promoting and functional properties, and the potential of their use in food and the pharmaceutical industry to support health. Various species of pine tree contain different compositions of bioactive compounds. Regardless of the solvent, method, pine species and plant part used, all pine extracts contain a high number of polyphenols. Pine tree extracts exhibit several described biological activities that may be beneficial to human health. The available examples of the application of pine elements in food are promising. The reuse of residual pine elements is still limited compared to its potential. In this case, it is necessary to conduct more research to find and develop new products and applications of pine residues and by-products.

scholarly journals In vitro antioxidant and wound-healing activities of hydrolyzed collagen from defatted Asian sea bass skin as influenced by different enzyme types and hydrolysis processes

RSC Advances ◽  
2021 ◽  
Vol 11 (30) ◽  
pp. 18144-18151
Author(s):  
Lalita Chotphruethipong ◽  
Thunwa Binlateh ◽  
Pilaiwanwadee Hutamekalin ◽  
Wanida Sukketsiri ◽  
Rotimi E. Aluko ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Functional Food ◽  
Sea Bass ◽  
Food Ingredient ◽  
Hydrolyzed Collagen ◽  
Asian Sea Bass ◽  
Antioxidant Potency ◽  
Sea Bass Skin ◽  
Lamellipodia Formation

Hydrolyzed collagen (HC) from sea bass skin prepared using papain and Alcalase had antioxidant potency and could enhance MRC-5 cell proliferation and lamellipodia formation. HC can be used as a nutraceutical or functional food ingredient.

Protective effects of zinc chelation in traumatic brain injury correlate with upregulation of neuroprotective genes in rat brain

2004 ◽  
Vol 355 (3) ◽  
pp. 221-225 ◽  
Author(s):  
Helen L Hellmich ◽  
Christopher J Frederickson ◽  
Douglas S DeWitt ◽  
Ricardo Saban ◽  
Margaret O Parsley ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Brain ◽  
Protective Effects ◽  
Zinc Chelation

Protective Effects of Topiramate against Hyperoxic Brain Injury in the Developing Brain

2009 ◽  
Vol 40 (01) ◽  
pp. 22-27 ◽  
Author(s):  
S. H. Kurul ◽  
U. Yiş ◽  
A. Kumral ◽  
K. Tuğyan ◽  
S. Cilaker ◽  
...  
Keyword(s):  
Brain Injury ◽  
Developing Brain ◽  
Protective Effects

Protective effects of melatonin in ischemic brain injury

2000 ◽  
Vol 29 (4) ◽  
pp. 217-227 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Giuseppina Costantino ◽  
Eloisa Gitto ◽  
Emanuela Mazzon ◽  
Francesco Fulia ◽  
...  
Keyword(s):  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Protective Effects ◽  
Ischemic Brain
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