Red ginseng protects against cisplatin-induced intestinal toxicity by inhibiting apoptosis and autophagy via the PI3K/AKT and MAPK signaling pathways

2020 ◽  
Vol 11 (5) ◽  
pp. 4236-4248
Author(s):  
Jun-jie Zhang ◽  
Jian-qiang Wang ◽  
Xing-yue Xu ◽  
Jia-yu Yang ◽  
Zi Wang ◽  
...  
Keyword(s):  
Side Effects ◽  
Signaling Pathways ◽  
Panax Ginseng ◽  
Mapk Signaling ◽  
Intestinal Damage ◽  
Red Ginseng ◽  
Intestinal Toxicity ◽  
Preventive Effects ◽  
Mapk Signaling Pathways

Although growing evidence has shown that ginseng (Panax ginseng C.A. Meyer.) exerts strong protective and preventive effects on cisplatin-induced side effects, the ameliorative effects of ginseng on intestinal damage caused by cisplatin are unknown to date.

scholarly journals Induction of Nrf2/ARE-mediated cytoprotective genes by red ginseng oil through ASK1–MKK4/7–JNK and p38 MAPK signaling pathways in HepG2 cells

2016 ◽  
Vol 40 (4) ◽  
pp. 423-430 ◽  
Author(s):  
Min Ji Bak ◽  
Van-Long Truong ◽  
Se-Yeon Ko ◽  
Xuan Ngan Giang Nguyen ◽  
Mira Jun ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
P38 Mapk ◽  
Hepg2 Cells ◽  
Mapk Signaling ◽  
Red Ginseng ◽  
Mapk Signaling Pathways

scholarly journals Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling Pathways

2021 ◽  
Vol 12 ◽  
Author(s):  
Xue Yang ◽  
Jiamin Liang ◽  
Ziyi Wang ◽  
Yuangang Su ◽  
Yunfei Zhan ◽  
...  
Keyword(s):  
Side Effects ◽  
Bone Loss ◽  
Signaling Pathways ◽  
Postmenopausal Osteoporosis ◽  
Mapk Pathway ◽  
Financial Burden ◽  
Mapk Signaling ◽  
Osteoclast Formation ◽  
Risk Of Death ◽  
Mapk Signaling Pathways

This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology. Postmenopausal osteoporosis (PMOP), which increases the risk of fracture, is the most common bone disease in women. PMOP not only increases the risk of death but also imposes a financial burden on countless families. At present, most of the drugs used to treat osteoporosis have significant side effects, so it is important to find effective anti-osteoporosis medications without major side effects. Sesamolin (Ses) is a kind of natural lignan extracted from sesame oil. Many researches have shown that Ses has anti-inflammatory, antioxidative, and anticancer effects, however it is still unknown whether it has any effect on osteoporosis. In this research, we explored the therapeutic effect of Ses in the process of osteoclast formation and bone resorption and found that Ses effectively inhibited osteoclast formation in vitro through TRAcP staining and hydroxyapatite resorption assays. Through Western blot analysis of the NF-κB pathway, MAPK pathway, c-Fos and NFATc1, it was found that Ses not only effectively inhibited the activation of NF-κB and MAPK signaling pathways induced by RANKL but also significantly reduced the protein expression of c-Fos and NFATc1. Several genes specifically expressed in osteoclasts were determined by qPCR, and Ses was also found to play a significant inhibitory role on the expression of these genes. Besides, an osteoporosis model induced in ovariectomized (OVX) mice was employed to verify that Ses could effectively reduce bone loss caused by estrogen deficiency in vivo. In conclusion, Ses showed promise as a new treatment for postmenopausal osteoporosis.

scholarly journals Urolithin A attenuates renal fibrosis by inhibiting TGF-β1/Smad and MAPK signaling pathways

2021 ◽  
Vol 83 ◽  
pp. 104547
Author(s):  
Zhenzhen Cheng ◽  
Jingjing Tu ◽  
Hongpan Zhang ◽  
Yi zhang ◽  
Benhong Zhou
Keyword(s):  
Signaling Pathways ◽  
Renal Fibrosis ◽  
Mapk Signaling ◽  
Urolithin A ◽  
Mapk Signaling Pathways ◽  
Tgf Β1

6-Bromoindirubin-3′-Oxime Suppresses LPS-Induced Inflammation via Inhibition of the TLR4/NF-κB and TLR4/MAPK Signaling Pathways

Inflammation ◽  
2019 ◽  
Vol 42 (6) ◽  
pp. 2192-2204 ◽  
Author(s):  
Chang Liu ◽  
Xin Tang ◽  
Wenjing Zhang ◽  
Guohong Li ◽  
Yingyu Chen ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways

scholarly journals Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152104 ◽  
Author(s):  
Francesco Pappalardo ◽  
Giulia Russo ◽  
Saverio Candido ◽  
Marzio Pennisi ◽  
Salvatore Cavalieri ◽  
...  
Keyword(s):  
Computational Modeling ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Melanoma Cancer ◽  
Mapk Signaling Pathways

Gβγ interactions with PH domains and Ras-MAPK signaling pathways

1995 ◽  
Vol 20 (4) ◽  
pp. 151-156 ◽  
Author(s):  
J INGLESE ◽  
W KOCH ◽  
K TOUHARA ◽  
R LEFKOWITZ
Keyword(s):  
Signaling Pathways ◽  
Mapk Signaling ◽  
Ph Domains ◽  
Mapk Signaling Pathways
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