Selenium deficiency causes immune damage by activating the DUSP1/NF-κB pathway and endoplasmic reticulum stress in chicken spleen

2020 ◽  
Vol 11 (7) ◽  
pp. 6467-6475 ◽  
Author(s):  
Zhang Yiming ◽  
Liu Qingqing ◽  
Yin Hang ◽  
Min Yahong ◽  
Li Shu
Keyword(s):  
Immune Response ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
T Lymphocyte ◽  
Tissue Damage ◽  
Selenium Deficiency ◽  
Lymphocyte Differentiation ◽  
Chicken Spleen

Selenium deficiency causes endoplasmic reticulum stress by affecting Ca2+ homeostasis and activates T lymphocyte differentiation via the DUSP1/NF-κB pathway. These factors together affect the immune response of the spleen and cause tissue damage.

Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine

BioFactors ◽  
2021 ◽  
Author(s):  
Yingying Zheng ◽  
Bo Zhang ◽  
Haoyue Guan ◽  
Xing Jiao ◽  
Jie Yang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Small Intestine ◽  
Endoplasmic Reticulum Stress ◽  
Selenium Deficiency

Roles of oxidative stress and endoplasmic reticulum stress in selenium deficiency-induced apoptosis in chicken liver

BioMetals ◽  
2015 ◽  
Vol 28 (2) ◽  
pp. 255-265 ◽  
Author(s):  
Linlin Yao ◽  
Qiang Du ◽  
Haidong Yao ◽  
Xi Chen ◽  
Ziwei Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Selenium Deficiency ◽  
Chicken Liver ◽  
Induced Apoptosis

scholarly journals The effect of selenium and polysaccharide of Atractylodes macrocephala Koidz. (PAMK) on endoplasmic reticulum stress and apoptosis in chicken spleen induced by heat stress

RSC Advances ◽  
2017 ◽  
Vol 7 (13) ◽  
pp. 7519-7525 ◽  
Author(s):  
Danning Xu ◽  
Wanyan Li ◽  
Bingxin Li ◽  
Yunbo Tian ◽  
Yunmao Huang
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Heat Stress ◽  
Endoplasmic Reticulum Stress ◽  
Er Stress ◽  
Chicken Spleen ◽  
Different Types ◽  
Atractylodes Macrocephala Koidz ◽  
Atractylodes Macrocephala ◽  
And Oxidative Stress

Endoplasmic reticulum (ER) stress and oxidative stress are involved in different types of stress induced injuries.

Selenium Deficiency Is Associated with Endoplasmic Reticulum Stress in a Rat Model of Cardiac Malfunction

2013 ◽  
Vol 156 (1-3) ◽  
pp. 196-201 ◽  
Author(s):  
Su-Qin Wang ◽  
Xiao-Lin Niu ◽  
Zhong-Wei Liu ◽  
Yan-He Zhu ◽  
Deng-Feng Gao
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Rat Model ◽  
Selenium Deficiency

scholarly journals SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis

2020 ◽  
Author(s):  
Yijun Wang ◽  
Jinbao Huang ◽  
Yong Sun ◽  
Jun He ◽  
Weiwei Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Dna Synthesis ◽  
Mrna Expression ◽  
Selenium Deficiency ◽  
Positive Association ◽  
Vero Cells ◽  
Serum Selenium ◽  
Significant Positive Association

AbstractA significant, positive association between selenium status and prognosis of SARS-CoV-2 infection has been identified among COVID-19 patients in China. Moreover, a German study revealed a pronounced deficit of serum selenium and SELENOP concentrations in COVID-19 patients, and selenium deficiency was associated with mortality risk from COVID-19. The present study investigated the influence of SARS-CoV-2 on gene expression of host selenoproteins which mediate many beneficial actions of selenium. We found that SARS-CoV-2 suppressed mRNA expression of selenoproteins associated with ferroptosis (GPX4), endoplasmic reticulum stress (SELENOF, SELENOK, SELENOM and SELENOS) and DNA synthesis (TXNRD3), while SARS-CoV-2 increased gene expression of IL-6 (an inflammatory cytokine positively correlated with severity of COVID-19), in Vero cells. These results provide a deeper insight into the connection between selenium and SARS-CoV-2 pathogenesis.

Abstract #403: The Glutathione Mimic Ebselen Inhibits Oxidative Stress but not Endoplasmic Reticulum Stress in Endothelial Cells.

2015 ◽  
Vol 21 ◽  
pp. 85-86
Author(s):  
William Kurban ◽  
Salma Makhoul Ahwach ◽  
Melanie Thomas ◽  
Luisa Onsteed-Haas ◽  
Michael Haas
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress
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