Potential use of ellagic acid for endometriosis treatment: its effect on a human endometrial cell cycle, adhesion and migration

2020 ◽  
Vol 11 (5) ◽  
pp. 4605-4614
Author(s):  
B. A. Mc Cormack ◽  
M. A. Bilotas ◽  
D. Madanes ◽  
A. G. Ricci ◽  
J. J. Singla ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stromal Cell ◽  
Endometrial Stromal Cell ◽  
Endometrial Cell ◽  
Endometrial Cells ◽  
Cell Adhesion And Migration ◽  
Stromal Cell Line ◽  
And Migration ◽  
Human Endometrial Cell ◽  
Potential Use

EA treatment decreases cell adhesion and migration of endometrial cells and alters the progression of an endometrial stromal cell line cycle.

scholarly journals Zinc(II) niflumato complex effects on MMP activity and gene expression in human endometrial cell lines

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Miroslava Rabajdová ◽  
Ivana Špaková ◽  
Zuzana Klepcová ◽  
Lukáš Smolko ◽  
Michaela Abrahamovská ◽  
...  
Keyword(s):  
Cell Line ◽  
High Selectivity ◽  
Chronic Inflammatory Disease ◽  
Good Prognosis ◽  
Endometrial Stromal Cell ◽  
Endometrial Cell ◽  
Proliferating Cells ◽  
Human Endometrial Stromal Cell ◽  
Stromal Cell Line ◽  
Human Endometrial Cell

AbstractEndometriosis is a chronic inflammatory disease which increasingly affects young women under 35 years of age and leads to subfertility even infertility. Analysis of the cytotoxic effect of zinc(II) niflumato complex with neocuproine ([Zn(neo)(nif)2] or Zn-Nif) on immortalized human endometriotic cell line (12Z) and on control immortalized human endometrial stromal cell line (hTERT) was performed using xCELLigence technology for approximately 72 h following the treatment with Zn-Nif as well as cell viability Trypan Blue Assay. 12Z cell line proliferated more slowly compared to unaffected cells, whereas hTERT cells did not show similar behavior after treatment. The complex probably reduces the effect of pro-inflammatory pathways due to the effect of NSAID, while presence of zinc might reduce the level of ROS and regulate ER2 levels and MMP activity. The observed effects and high selectivity for rapidly proliferating cells with increased inflammatory activity suggest a good prognosis of successful decrease of endometriosis stage with this complex.

scholarly journals A Novel Immortalized Human Endometrial Stromal Cell Line with Normal Progestational Response

Endocrinology ◽  
2004 ◽  
Vol 145 (5) ◽  
pp. 2291-2296 ◽  
Author(s):  
Graciela Krikun ◽  
Gil Mor ◽  
Ayesha Alvero ◽  
Seth Guller ◽  
Frederick Schatz ◽  
...  
Keyword(s):  
Cell Line ◽  
Stromal Cell ◽  
Endometrial Stromal Cell ◽  
Human Endometrial Stromal Cell ◽  
Stromal Cell Line

Regulation of the cytokinesis cleavage furrow by PKCε

2014 ◽  
Vol 42 (6) ◽  
pp. 1534-1537 ◽  
Author(s):  
Nicola Brownlow ◽  
Tanya Pike ◽  
Victoria Crossland ◽  
Jeroen Claus ◽  
Peter Parker
Keyword(s):  
Cell Cycle ◽  
Actin Binding ◽  
Cleavage Furrow ◽  
Binding Region ◽  
Serine Threonine Kinase ◽  
Threonine Kinase ◽  
Dna Segregation ◽  
Daughter Cells ◽  
Cell Adhesion And Migration ◽  
And Migration

Cytokinesis is the final act of the cell cycle where the replicated DNA and cellular contents are finally split into two daughter cells. This process is very tightly controlled as DNA segregation errors and cytokinesis failure is commonly associated with aneuploidy and aggressive tumours. Protein kinase Cε (PKCε) is a lipid-activated serine/threonine kinase that is part of the PKC superfamily. PKCε plays a complex role in the regulation of migration, adhesion and cytokinesis and in the present article we discuss the interplay between these processes. Integrin-mediated interaction with the actin cytoskeleton is a known regulator of cell adhesion and migration and there is emerging evidence that this pathway may also be essential for cytokinesis. We discuss evidence that a known actin-binding region in PKCε is involved in PKCε-mediated regulation of cytokinesis, providing a link between integrin-mediated stabilization of the cytokinesis furrow and PKCε recruitment.

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