Pedro Ximenez sun-dried grape must: a dietary supplement for a healthy longevity

2020 ◽  
Vol 11 (5) ◽  
pp. 4387-4402
Author(s):  
Noelia Morales-Prieto ◽  
Paula V. Huertas-Abril ◽  
Nieves López de Lerma ◽  
Isabel. L. Pacheco ◽  
José Pérez ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Aging Process ◽  
Healthy Aging ◽  
Grape Must ◽  
Aged Mice ◽  
Healthy Longevity ◽  
Mice Liver ◽  
Pedro Ximénez

Sun-dried Pedro Ximénez white grapes must (PXM) is a potent antioxidant that regularizes apoptosis, proliferation, and regeneration of the structure and the function of aged mice liver. PXM consumption contributes to a healthy aging process.

scholarly journals Cerebral Mitochondrial Function and Cognitive Performance during Aging: A Longitudinal Study in NMRI Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Martina Reutzel ◽  
Rekha Grewal ◽  
Benjamin Dilberger ◽  
Carmina Silaidos ◽  
Aljoscha Joppe ◽  
...  
Keyword(s):  
Longitudinal Data ◽  
Cognitive Performance ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Function ◽  
Aging Process ◽  
Brain Aging ◽  
Model Organisms ◽  
Nmri Mice ◽  
Aged Mice ◽  
The Brain

Brain aging is one of the major risk factors for the development of several neurodegenerative diseases. Therefore, mitochondrial dysfunction plays an important role in processes of both, brain aging and neurodegeneration. Aged mice including NMRI mice are established model organisms to study physiological and molecular mechanisms of brain aging. However, longitudinal data evaluated in one cohort are rare but are important to understand the aging process of the brain throughout life, especially since pathological changes early in life might pave the way to neurodegeneration in advanced age. To assess the longitudinal course of brain aging, we used a cohort of female NMRI mice and measured brain mitochondrial function, cognitive performance, and molecular markers every 6 months until mice reached the age of 24 months. Furthermore, we measured citrate synthase activity and respiration of isolated brain mitochondria. Mice at the age of three months served as young controls. At six months of age, mitochondria-related genes (complex IV, creb-1, β-AMPK, and Tfam) were significantly elevated. Brain ATP levels were significantly reduced at an age of 18 months while mitochondria respiration was already reduced in middle-aged mice which is in accordance with the monitored impairments in cognitive tests. mRNA expression of genes involved in mitochondrial biogenesis (cAMP response element-binding protein 1 (creb-1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α), nuclear respiratory factor-1 (Nrf-1), mitochondrial transcription factor A (Tfam), growth-associated protein 43 (GAP43), and synaptophysin 1 (SYP1)) and the antioxidative defense system (catalase (Cat) and superoxide dismutase 2 (SOD2)) was measured and showed significantly decreased expression patterns in the brain starting at an age of 18 months. BDNF expression reached, a maximum after 6 months. On the basis of longitudinal data, our results demonstrate a close connection between the age-related decline of cognitive performance, energy metabolism, and mitochondrial biogenesis during the physiological brain aging process.

scholarly journals Carotenoids: How Effective Are They to Prevent Age-Related Diseases?

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1801 ◽  
Author(s):  
Bee Ling Tan ◽  
Mohd Esa Norhaizan
Keyword(s):  
Oxidative Stress ◽  
Healthy Aging ◽  
The Elderly ◽  
Antioxidant Systems ◽  
Potential Intervention ◽  
Healthy Longevity ◽  
Age Related ◽  
Underlying Mechanisms ◽  
Endogenous Antioxidant

Despite an increase in life expectancy that indicates positive human development, a new challenge is arising. Aging is positively associated with biological and cognitive degeneration, for instance cognitive decline, psychological impairment, and physical frailty. The elderly population is prone to oxidative stress due to the inefficiency of their endogenous antioxidant systems. As many studies showed an inverse relationship between carotenoids and age-related diseases (ARD) by reducing oxidative stress through interrupting the propagation of free radicals, carotenoid has been foreseen as a potential intervention for age-associated pathologies. Therefore, the role of carotenoids that counteract oxidative stress and promote healthy aging is worthy of further discussion. In this review, we discussed the underlying mechanisms of carotenoids involved in the prevention of ARD. Collectively, understanding the role of carotenoids in ARD would provide insights into a potential intervention that may affect the aging process, and subsequently promote healthy longevity.

scholarly journals Educação permanente, qualidade de vida e envelhecimento saudável na escola: estudo exploratório

2016 ◽  
Vol 15 ◽  
pp. 567
Author(s):  
Adriana Cortez Fernandes ◽  
Elaine Antunes Cortez ◽  
Marcos Paulo Fonseca Corvino
Keyword(s):  
Quality Of Life ◽  
Health Education ◽  
Aging Process ◽  
Healthy Aging ◽  
Methodological Approach ◽  
Life Quality ◽  
Exploratory Research ◽  
Theoretical Frameworks ◽  
Leave Of Absence

This research intention is to contribute to the maintenance of quality of life during the aging process of workers of a technical school. Aim: To use continuing health education as a tool for the development of the theme regarding quality of life in the healthy aging process. Method This is descriptive-exploratory, research-action, with a qualitative methodological approach research. Semi-structured questionnaires and the observation of educational groups will be used to collect data. Inclusion criteria: to work in the language centre or in the computing centre. Exclusion criteria: employees who are currently  in  any  kind  of  leave  of  absence,  including  annual holiday  leaves.  The information collected through the questionnaire will be interpreted according to Bardin's Content Analysis method. The remaining stages will be analysed using Paulo Freire and Permanent  Health  Education  Policy  (Política  Nacional  de  Educação Permanente  em Saúde)  theoretical  frameworks.    Subsequently,  the  results  will  be  presented  to  the employees,  allowing  them  to  ponder  over  the  importance  of  continuing  education  for having life quality during the aging process. 

Healthy and Pathological Neurocognitive Aging: Spectral and Functional Connectivity Analyses Using Magnetoencephalography

2019 ◽  
Author(s):  
Gianluca Susi ◽  
Jaisalmer de Frutos-Lucas ◽  
Guiomar Niso ◽  
Su Miao Ye-Chen ◽  
Luis Antón Toro ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Aging Process ◽  
Healthy Aging ◽  
Oscillatory Activity ◽  
Good Resolution ◽  
Brain Areas ◽  
Spectral Content ◽  
Pathological Conditions ◽  
Neurocognitive Aging ◽  
Invasive Techniques

Oscillatory activity present in brain signals reflects the underlying time-varying electrical discharges within and between ensembles of neurons. Among the variety of non-invasive techniques available for measuring of the brain’s oscillatory activity, magnetoencephalography (MEG) presents a remarkable combination of spatial and temporal resolution, and can be used in resting-state or task-based studies, depending on the goals of the experiment. Two important kinds of analysis can be carried out with the MEG signal: spectral a. and functional connectivity (FC) a. While the former provides information on the distribution of the frequency content within distinct brain areas, FC tells us about the dependence or interaction between the signals stemming from two (or among many) different brain areas. The large frequency range combined with the good resolution offered by MEG makes MEG-based spectral and FC analyses able to highlight distinct patterns of neurophysiological alterations during the aging process in both healthy and pathological conditions. Since disruption in spectral content and functional interactions between brain areas could be accounted for by early neuropathological changes, MEG could represent a useful tool to unveil neurobiological mechanisms related to the cognitive decline observed during aging, particularly suitable for the detection of functional alterations, and then for the discovery of potential biomarkers in case of pathology. The aging process is characterized by alterations in the spectral content across the brain. At the network level, FC studies reveal that older adults experience a series of changes that make them more vulnerable to cognitive interferences. While special attention has been dedicated to the study of pathological conditions (in particular, mild cognitive impairment and Alzheimer’s disease), the lack of studies addressing the features of FC in healthy aging is noteworthy. This area of research calls for future attention because it is able to set the baseline from which to draw comparisons with different pathological conditions.

Individual DNA Methylation Profile is Correlated with Age and can be Targeted to Modulate Healthy Aging and Longevity

2019 ◽  
Vol 25 (39) ◽  
pp. 4139-4149 ◽  
Author(s):  
Francesco Guarasci ◽  
Patrizia D'Aquila ◽  
Alberto Montesanto ◽  
Andrea Corsonello ◽  
Dina Bellizzi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Aging Process ◽  
Healthy Aging ◽  
Nuclear Dna ◽  
Epigenetic Modification ◽  
Biological Aging ◽  
Biomarkers Of Aging ◽  
Age Related

: Patterns of DNA methylation, the best characterized epigenetic modification, are modulated by aging. In humans, different studies at both site-specific and genome-wide levels have reported that modifications of DNA methylation are associated with the chronological aging process but also with the quality of aging (or biological aging), providing new perspectives for establishing powerful biomarkers of aging. : In this article, the role of DNA methylation in aging and longevity has been reviewed by analysing literature data about DNA methylation variations occurring during the lifetime in response to environmental factors and genetic background, and their association with the aging process and, in particular, with the quality of aging. Special attention has been devoted to the relationship between nuclear DNA methylation patterns, mitochondrial DNA epigenetic modifications, and longevity. Mitochondrial DNA has recently been reported to modulate global DNA methylation levels of the nuclear genome during the lifetime, and, in spite of the previous belief, it has been found to be the target of methylation modifications. : Analysis of DNA methylation profiles across lifetime shows that a remodeling of the methylome occurs with age and/or with age-related decline. Thus, it can be an excellent biomarker of aging and of the individual decline and frailty status. The knowledge about the mechanisms underlying these modifications is crucial since it might allow the opportunity for targeted treatment to modulate the rate of aging and longevity.

scholarly journals The KEAP1-NRF2 System in Healthy Aging and Longevity

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1929
Author(s):  
Daisuke Matsumaru ◽  
Hozumi Motohashi
Keyword(s):  
Oxidative Stress ◽  
Environmental Factors ◽  
Aging Process ◽  
Healthy Aging ◽  
Target Genes ◽  
Defense Mechanism ◽  
Related Factor ◽  
Oxygen Species ◽  
Programmed Aging ◽  
Central Nervous Systems

Aging is inevitable, but the inherently and genetically programmed aging process is markedly influenced by environmental factors. All organisms are constantly exposed to various stresses, either exogenous or endogenous, throughout their lives, and the quality and quantity of the stresses generate diverse impacts on the organismal aging process. In the current oxygenic atmosphere on earth, oxidative stress caused by reactive oxygen species is one of the most common and critical environmental factors for life. The Kelch-like ECH-associated protein 1-NFE2-related factor 2 (KEAP1-NRF2) system is a critical defense mechanism of cells and organisms in response to redox perturbations. In the presence of oxidative and electrophilic insults, the thiol moieties of cysteine in KEAP1 are modified, and consequently NRF2 activates its target genes for detoxification and cytoprotection. A number of studies have clarified the contributions of the KEAP1-NRF2 system to the prevention and attenuation of physiological aging and aging-related diseases. Accumulating knowledge to control stress-induced damage may provide a clue for extending healthspan and treating aging-related diseases. In this review, we focus on the relationships between oxidative stress and aging-related alterations in the sensory, glandular, muscular, and central nervous systems and the roles of the KEAP1-NRF2 system in aging processes.

scholarly journals Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Alessandro Bitto ◽  
Takashi K Ito ◽  
Victor V Pineda ◽  
Nicolas J LeTexier ◽  
Heather Z Huang ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Optimal Dose ◽  
Increase Life Expectancy ◽  
Middle Aged ◽  
Short Term ◽  
Cancer Prevalence ◽  
Rapamycin Treatment ◽  
Hematopoietic Malignancies ◽  
Aged Mice ◽  
Age Related

The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy aging. Here we show that 3 months of rapamycin treatment is sufficient to increase life expectancy by up to 60% and improve measures of healthspan in middle-aged mice. This transient treatment is also associated with a remodeling of the microbiome, including dramatically increased prevalence of segmented filamentous bacteria in the small intestine. We also define a dose in female mice that does not extend lifespan, but is associated with a striking shift in cancer prevalence toward aggressive hematopoietic cancers and away from non-hematopoietic malignancies. These data suggest that a short-term rapamycin treatment late in life has persistent effects that can robustly delay aging, influence cancer prevalence, and modulate the microbiome.

scholarly journals Overweight: A Protective Factor against Comorbidity in the Elderly

2019 ◽  
Vol 16 (19) ◽  
pp. 3656 ◽  
Author(s):  
Giovanni Mario Pes ◽  
Giulia Licheri ◽  
Sara Soro ◽  
Nunzio Pio Longo ◽  
Roberta Salis ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Aging Process ◽  
Healthy Aging ◽  
Protective Factor ◽  
The Elderly ◽  
Unexpected Finding ◽  
Digestive Endoscopy ◽  
Upper Digestive Endoscopy ◽  
Age Range ◽  
The Relationship

The aim of this study was to investigate the relationship between body mass index (BMI) categories and comorbidity in 9067 patients (age range 18‒94 years) who underwent upper digestive endoscopy in Northern Sardinia, Italy. The majority of participants (62.2%) had a BMI under 25 kg/m2, overweight was detected in 30.4%, and obesity (BMI ≥ 30 kg/m2) in 7.4% of patients. The most frequent illness recorded was hypertension followed by cardiovascular and liver disease. The multivariate analysis, after adjusting for sex, residence, marital status, smoking habits, occupation and hospitalization detected an association between comorbidity and aging that was statistically significant and progressive. Among patients younger than 60 years (n = 5612) the comorbidity risk was higher for BMI ranging 27.5‒29.9 kg/m2 compared with BMI 25.0‒27.4 kg/m2 (RR = 1.38; 95% CI 1.27‒1.50 vs. RR = 0.86; 95% CI 0.81‒0.90). In patients older than 60 years (n= 3455) the risk was lower for a BMI in the range 27.5–29.9 kg/m2 compared with a BMI in the range 25.0–27.4 kg/m2 (RR = 1.11; 95% CI 1.05‒1.18 vs. RR = 1.28; 95% CI 1.21‒1.35). These results suggest that being moderately overweight is a marker of a healthy aging process and might protect, at least in part, against comorbidity. However, further research is needed to better understand this unexpected finding.

scholarly journals Ageing process and policosanol effects

2021 ◽  
Vol 12 (2) ◽  
pp. 273-283
Author(s):  
José Illnait-Ferrer ◽  
Julio César Fernández-Travieso ◽  
Yenney Reyes-Nuñez ◽  
Alicia de la Caridad Duquesne-Chávez
Keyword(s):  
Aging Process ◽  
Healthy Aging ◽  
Normal Development ◽  
Experimental Models ◽  
Point Of View ◽  
Contemporary Society ◽  
Ampk Activation ◽  
Biochemical Processes ◽  
The Social

The fundamental concepts of the aging process are exposed: Its dimension as a health problem, aspects related to its repercussion from the social point of view, and Its influence on aspects that can affect the normal development of contemporary society. The roles of genetics, cellular and biochemical processes that concur in the development of aging is analyzed, making special reference to the role of Adenosine Mono Phosphate Kinase [AMPK]. activation in the regulation of the aging process and the participation of mechanisms for its activation. It is concluded that Policosanol is a medicament of natural origin that could be proposed as candidate to be used for a healthy aging, based on the results of various investigations in experimental models and data obtained from different clinical trials.

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