Tomato seed oil attenuates hyperlipidemia and modulates gut microbiota in C57BL/6J mice

2020 ◽  
Vol 11 (5) ◽  
pp. 4275-4290
Author(s):  
Wen-Sen He ◽  
Lingling Li ◽  
Jiaxin Rui ◽  
Junjie Li ◽  
Yuying Sun ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
Fatty Acid Metabolism ◽  
Seed Oil ◽  
Acid Metabolism ◽  
Cholesterol Metabolism ◽  
Tomato Seed ◽  
Tomato Seed Oil

TSO can significantly improve fatty acid metabolism and cholesterol metabolism, thereby inhibiting obesity and hypercholesterolemia. TSO can favorably modulate the gut microbiota.

scholarly journals Evaluation of the Bioactive Compounds Found in Tomato Seed Oil and Tomato Peels Influenced by Industrial Heat Treatments

Foods ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 110
Author(s):  
Katalin Szabo ◽  
Francisc Vasile Dulf ◽  
Bernadette-Emőke Teleky ◽  
Panagiota Eleni ◽  
Christos Boukouvalas ◽  
...  
Keyword(s):  
Fatty Acid ◽  
High Performance ◽  
Seed Oil ◽  
Edible Oils ◽  
Action Plan ◽  
Syringic Acid ◽  
Tomato Seed ◽  
Tomato Processing ◽  
Main Fatty Acid ◽  
Tomato Seed Oil

The circular economy action plan involves principles related to food waste reduction and integration of recovered nutrients to the market. In this context, the present study aims to highlight the valuable bioactive components found in tomato processing by-products (carotenoids, phenolic compounds and fatty acids) influenced by industrial pre-treatments, particularly cold break (CB) process at 65–75 °C and hot break (HB) process at 85–95 °C. The fatty acid profile of the tomato seed oil was examined by gas chromatography coupled to mass spectrometry (GC-MS), individual carotenoid and phenolic compositions were determined by high performance liquid chromatography (HPLC) and the viscoelastic properties were evaluated by rheological measurements. The physicochemical properties revealed appropriate characteristics of the tomato seed oil to fit the standards of generally accepted edible oils, for both CB and HB derived samples, however, significant qualitative and quantitative differences were detected in their phenolic composition and carotenoids content. Lycopene (37.43 ± 1.01 mg/100 mL) was a major carotenoid in the examined samples, linoleic acid was the main fatty acid (61.73%) detected in the tomato seed oil and syringic acid appeared to be one of two major phenolic acids detected in the samples of CB process. Our findings extend the boundaries of tomato processing industry by validating that tomato seed oil is a bioactive rich edible oil with additional health benefits, which can be integrated in functional food products.

scholarly journals Effect of a high-collagen peptide diet on the gut microbiota and short-chain fatty acid metabolism

2020 ◽  
Vol 75 ◽  
pp. 104278
Author(s):  
Fengfeng Mei ◽  
Zhouwei Duan ◽  
Muxue Chen ◽  
Jinfeng Lu ◽  
Meihui Zhao ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
Fatty Acid Metabolism ◽  
Short Chain Fatty Acid ◽  
Acid Metabolism ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Collagen Peptide

scholarly journals EFFECT OF SUNLIGHT ON FATTY ACID COMPOSITION OF TOMATO SEED OIL STORED IN DIFFERENT COLORED BOTTLES

2018 ◽  
Vol 43 (1) ◽  
pp. 122-128
Author(s):  
Burcu Aydoğan-Coşkun ◽  
◽  
Hacer Çoklar ◽  
Mehmet Akbulut
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Seed Oil ◽  
Tomato Seed ◽  
Tomato Seed Oil

scholarly journals Gut microbiota dysregulation of fatty acid metabolism accelerates ages-mediated knee joint degeneration

2020 ◽  
Vol 28 ◽  
pp. S21-S22
Author(s):  
H.-J. Ke ◽  
W.-S. Lian ◽  
C.-W. Kuo ◽  
Y.-S. Chen ◽  
F.-S. Wang
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
Knee Joint ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Joint Degeneration

scholarly journals ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

2021 ◽  
Vol 9 ◽  
Author(s):  
Tingting Bi ◽  
Ruiqi Feng ◽  
Libin Zhan ◽  
Weiming Ren ◽  
Xiaoguang Lu
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
Cognitive Decline ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Neurological Diseases ◽  
Metabolic Changes ◽  
Protective Mechanisms ◽  
Prevention And Treatment ◽  
Zdf Rats

Gut microbiota is becoming one of the key determinants in human health and disease. Shifts in gut microbiota composition affect cognitive function and provide new insights for the prevention and treatment of neurological diseases. Diabetes-associated cognitive decline (DACD) is one of the central nervous system complications of type 2 diabetes mellitus (T2DM). ZiBuPiYin recipe (ZBPYR), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of T2DM and prevention of DACD. However, the contribution of ZBPYR treatment to the interaction between the gut microbiota and metabolism for preventing and treating DACD remains to be clarified. Here, we investigate whether the gut microbiota plays a key role in ZBPYR-mediated prevention of DACD and treatment of T2DM via incorporating microbiomics and metabolomics, and investigate the links between the microbiota–gut–brain axis interaction and the efficacy of ZBPYR in ZDF rats. In the current study, we found that ZBPYR treatment produced lasting changes in gut microbiota community and metabolites and remotely affected hippocampus metabolic changes, thereby improving memory deficits and reversing β-amyloid deposition and insulin resistance in the brain of ZDF rats from T2DM to DACD. This may be related to a series of metabolic changes affected by gut microbiota, including alanine, aspartic acid, and glutamic acid metabolism; branched-chain amino acid metabolism; short-chain fatty acid metabolism; and linoleic acid/unsaturated fatty acid metabolism. In summary, this study demonstrates that prevention and treatment of DACD by ZBPYR partly depends on the gut microbiota, and the regulatory effects of bacteria-derived metabolites and microbiota–gut–brain axis are important protective mechanisms of ZBPYR.

scholarly journals MSM and sesame seed oil improve hyperlipidemia and PUFA metabolism in the db/db mouse

2021 ◽  
Author(s):  
Cameron V. Fili ◽  
Ling Lin ◽  
Jonathan Chapman ◽  
David Hamilton ◽  
Charles R. Yates
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Seed Oil ◽  
Acid Metabolism ◽  
Sesame Seed ◽  
Hdl Cholesterol ◽  
Diabetic Control ◽  
Sesame Seed Oil

AbstractBackgroundAn estimated 463 million people worldwide suffer from diabetes, and that number is projected to rise significantly to 700 million by 2045. One of the hallmarks of type 2 diabetes and metabolic syndrome is alterations in the lipid profile and polyunsaturated fatty acid metabolism.ObjectiveThe objective of this study was to identify lipid alterations in leptin receptor deficient BKS.Cg-Dock7m+/+ Leprdb/J (db/db) mice, a murine model of type 2 diabetes, for the purpose of establishing a baseline biological signature for the subsequent evaluation of natural products with purported lipid-altering activity.MethodsSix-week old male db/db mice (n = 10/group) were randomized to the following groups: 1) diabetic control with no treatment, 2) methylsulfonylmethane (MSM) treatment (3.81 ± 0.33 g/kg), 3) sesame seed oil (SSO) treatment (23.54 ± 2.91 mg/kg), and 4) MSM and SSO combination treatment. Eight-week old male C57BL6/J mice (n=10) were used as a non-diabetic control group.ResultsSerum triglycerides and total cholesterol were significantly increased in the db/db model compared to nondiabetic control, mimicking the diabetic condition in people. HDL-cholesterol was significantly increased in all db/db treatment groups, with the most significant treatment effect in the MSM and SSO combination group, with a corresponding decrease in non-HDL cholesterol (LDL and VLDL). With regard to fatty acid metabolism, serum total polyunsaturated fatty acid (PUFA) levels were significantly reduced in diabetic mice compared to control mice. In contrast, feeding of only SSO reversed this effect such that fed mice exhibited serum PUFA levels comparable to control mice.ConclusionsTreatment of db/db mice with MSM and SSO improved commonly measured clinical parameters in serum lipid panels. The combination of MSM and SSO treatment’s effects on HDL and non-HDL cholesterol and fatty acid metabolism could lead to improved clinical outcomes in people such as reduced incidence of atherosclerosis and hepatic steatosis.

Fatty Acid Composition of Tomato Seed Oil

1972 ◽  
Vol 55 (3) ◽  
pp. 645-647
Author(s):  
G C Tsatsaronis ◽  
D G Boskou
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Seed Oil ◽  
Tomato Seed ◽  
Tomato Seeds ◽  
Fractionation Procedure ◽  
Chromatographic Peaks ◽  
Palmitic Acids ◽  
Tomato Seed Oil

Abstract The fatty acid composition of the oil extracted from tomato seeds was determined by GLC. A urea fractionation procedure and preparative GLC were used to detect esters present in small or trace amounts. Linoleic, oleic, and palmitic acids were predominant. Odd- and even-chain length saturated acids from C12-C28 were present. Hexadecenoic, heptadecenoic, and eicosenoic acids were also detected. Minor chromatographic peaks preceding some of the saturated esters were attributed to branched acids.

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