Dietary supplementation of l-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction

2020 ◽  
Vol 11 (5) ◽  
pp. 4456-4470 ◽  
Author(s):  
Hao Zhang ◽  
Yi Ma ◽  
Mengzhi Wang ◽  
Mabrouk Elsabagh ◽  
Juan J. Loor ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Barrier Function ◽  
Intrauterine Growth Restriction ◽  
Intrauterine Growth Retardation ◽  
Dietary Supplementation ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Mitochondrial Functions ◽  
And Mitochondrial Functions

The work aimed at investigating the effects of N-carbamylglutamate (NCG) or l-arginine (Arg) supplementation on the duodenal mitophagy, inflammation, and barrier function in suckling lambs suffering from intrauterine-growth-retardation (IUGR).

scholarly journals Some health aspects of children born with different types of intrauterine growth restriction during the early neonatal period

2017 ◽  
Vol 98 (1) ◽  
pp. 44-52 ◽  
Author(s):  
V V Derevtsov
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Restriction ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Growth Restriction ◽  
Past Medical History ◽  
Intrauterine Growth ◽  
Septal Defects ◽  
Early Neonatal Period ◽  
Different Types

Aim. To evaluate some health aspects of children born with different types of intrauterine growth restriction during the early neonatal period.Methods. Clinical and anamnestic, physical, laboratory, electrophysiological, ultrasound and statistical methods were used. Children’s past medical history, development during early neonatal period, physical development, functioning of autonomic nervous system and cardiovascular system were assessed.Results. It was revealed that development of different types of intrauterine growth restriction is related to father and mother’s age at the time of pregnancy, women’s body mass before pregnancy, and time of pregnancy complication development (abortion risk, pre-eclampsia, arterial hypertension, Rh-immunization, edema). Fetuses with asymmetric type of intrauterine growth retardation had survived hypoxia more often (by 4.87 times). Children with symmetrical type of intrauterine growth retardation were more often born by C-section (by 2.66 times), with smaller anthropometric measurements, with more frequent and severe hypotrophy, moderate and severe cerebral ischemia and mild intracranial hemorrhage, cryptorchidism, kidney diseases, atrial septal defects, muscular ventricular septal defects, open arterial duct, and depleted reserves. Children with asymmetric type of intrauterine growth retardation more often had hypoglycemia, jaundice, polycythemia, restricted adaptation reserves, myocardial metabolic disorders, anterior mitral valve leaflet prolapse, posthypoxic changes similar to hypertrophic cardiopathy.Conclusion. Revealed features of past medical history, development during early neonatal period of life, physical development, functioning of autonomic nervous system and cardiovascular system in different types of children’s intrauterine growth restriction can promote formulation of criteria for early diagnosis of adaptive and reserve disorders and identification of dispensary groups.

Intrauterine growth restriction induces skin inflammation, increases TSLP and impairs epidermal barrier function

2020 ◽  
Vol 98 (2) ◽  
pp. 279-289 ◽  
Author(s):  
Laura Polányi ◽  
Carien M. Niessen ◽  
Christina Vohlen ◽  
Julia Stinn ◽  
Tobias Kretschmer ◽  
...  
Keyword(s):  
Barrier Function ◽  
Intrauterine Growth Restriction ◽  
Skin Inflammation ◽  
Growth Restriction ◽  
Epidermal Barrier ◽  
Intrauterine Growth

Dietary N-carbamylglutamate and rumen-protected L-arginine supplementation during intrauterine growth restriction in undernourished ewes improve fetal thymus development and immune function

2018 ◽  
Vol 30 (11) ◽  
pp. 1522 ◽  
Author(s):  
Hao Zhang ◽  
Fangfang Zhao ◽  
Haitao Nie ◽  
Tiewei Ma ◽  
Ziyu Wang ◽  
...  
Keyword(s):  
Immune Function ◽  
Intrauterine Growth Restriction ◽  
National Research Council ◽  
Dietary Supplementation ◽  
Growth Restriction ◽  
Negative Effects ◽  
Fetal Thymus ◽  
Intrauterine Growth ◽  
Thymus Development ◽  
Hu Sheep

The aims of the present study were to determine whether dietary supplementation with N-carbamylglutamate (NCG) and rumen-protected l-arginine (RP-Arg) to underfed Hu sheep would improve fetal thymus development and immune function. From Day 35 to Day 110 of gestation, 32 Hu ewes carrying twin fetuses were randomly allocated to one of four groups (n = 8 per group): 100% National Research Council (NRC)-recommended nutrient requirements (CON), 50% NRC recommendations (RES), 50% NRC recommendations supplemented with 20 g day−1 RP-Arg (RES+ARG), and 50% NRC recommendations supplemented with 5 g day−1 NCG (RES+NCG). Medullary thickness was increased (P < 0.05) in RES compared with CON ewes, but was reduced (P < 0.05) in both RES+ARG and RES+NCG ewes compared with RES ewes. There were no differences in superoxide dismutase and glutathione peroxidase activity or malondialdehyde levels in the RES+ARG and RES+NCG groups compared with the CON group (P > 0.05). Concentrations of IgA, interleukin (IL)-1β and IL-10 in fetal umbilical cord blood were reduced (P < 0.05) in RES compared with CON ewes, but were increased (P < 0.05) in both RES+ARG and RES+NCG ewes. Expression of Bax, Fas and p53 mRNA was increased (P < 0.05) in RES compared with CON ewes, but were reduced (P > 0.05) in both RES+ARG and RES+NCG ewes. These results indicate that dietary supplementation with NCG and RP-Arg could help alleviate the negative effects of intrauterine growth restriction on fetal thymus development and immune function.

Intrauterine growth retardation (upavishataka garbhavyapad) and it’s ayurved and modern management – review of literatures.

2020 ◽  
Vol 8 (02) ◽  
Author(s):  
Snehal Snehal
Keyword(s):  
Birth Weight ◽  
Intrauterine Growth Restriction ◽  
Intrauterine Growth Retardation ◽  
Modern Science ◽  
Neonatal Morbidity ◽  
Signs And Symptoms ◽  
Placental Insufficiency ◽  
Growth Restriction ◽  
Basic Principles ◽  
Intrauterine Growth

According to modern science , intrauterine Growth Restriction (IUGR) is an important causes of fetal and neonatal morbidity and mortality.    In IUGR development and maturity of foetus delayed or impaired . Fetal growth restriction is said to be present in those babies whose birth weight is below the 10th percentile of the average for the gestational age. Growth restriction can occure in preterm , term, or post term babies.(1)  Placental insufficiency or utero placental insufficiency is most imp. Cause of intrauterine growth restriction.    The signs and   symptoms of IUGR and Upavishtaka are same .In Ayurveda Upavishtak is described under Garbhavyapads.In ayurvedic literature , there are many natural formulations ,various drugs have been described  for treatment is based upon basic principles such as rasa , guna ,veerya,vipak of drugs.Hence to study the consept of IUGR (upavishtaka) according to modern and Ayurveda; this topic has been selected for study.

Imbalance in the system L-arginin-NO in pathogenesis of obstetric complications and intrauterine growth retardation (Literature review)

2016 ◽  
pp. 43-47
Author(s):  
O.V. Basystyi ◽  
Keyword(s):  
Nitric Oxide ◽  
Literature Review ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Obstetric Complications ◽  
Pathogenetic Role ◽  
Intrauterine Growth ◽  
System L ◽  
Nitric Oxide Deficiency

The data of domestic and foreign literature on etiology, pathogenesis and intrauterine growth retardation diagnosis are presented in the paper. It highlights pathogenetic role of nitric oxide deficiency in case of obstetric complications and intrauterine growth retardation. Key words: intrauterine growth retardation (IUGR), system L-arginin–NO, obstetric complications.

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

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