scholarly journals The influence of phosphatidylserine localisation and lipid phase on membrane remodelling by the ESCRT-II/ESCRT-III complex

2020 ◽  
Author(s):  
Andrew Booth ◽  
Christopher Marklew ◽  
Barbara Ciani ◽  
Paul A. Beales
Keyword(s):  
Lipid Bilayers ◽  
Supramolecular Structures ◽  
Lipid Phase ◽  
Endosomal Sorting ◽  
Membrane Invagination

The endosomal sorting complex required for transport (ESCRT) organises in supramolecular structures on the surface of lipid bilayers to drive membrane invagination and scission of intraluminal vesicles (ILVs), a process...

Fish Antifreeze Glycoproteins Protect Cellular Membranes During Lipid-Phase Transitions

Physiology ◽  
1997 ◽  
Vol 12 (4) ◽  
pp. 189-194
Author(s):  
LM Hays ◽  
RE Feeney ◽  
F Tablin ◽  
AE Oliver ◽  
NJ Walker ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Liquid Crystalline ◽  
Antarctic Fish ◽  
Cell Types ◽  
Lipid Phase ◽  
Crystal Formation ◽  
Ice Crystal ◽  
Antifreeze Glycoproteins ◽  
Lipid Phase Transitions ◽  
Gel Phase

Antifreeze proteins from Antarctic fish depress solution freezing temperatures, inhibit ice crystal formation, and prevent recrystallization on rewarming. They have been used to enhance survival of some cell types during hypothermic storage. The mechanism of their protection is thought to be important during the transition of lipid bilayers from a liquid crystalline to a gel phase.

Interaction of N-alkylanthracyclines with lipid bilayers: correlations between partition coefficients, lipid phase distributions and thermotropic behavior

1989 ◽  
Vol 51 (2) ◽  
pp. 105-118 ◽  
Author(s):  
Panayiotis P. Constantinides ◽  
Lily Ghosaini ◽  
Naoyoshi Inouchi ◽  
Shinichi Kitamura ◽  
Ramakrishnan Seshadri ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Partition Coefficients ◽  
Lipid Phase

Making lipid membranes even tougher

2007 ◽  
Vol 22 (8) ◽  
pp. 2189-2194 ◽  
Author(s):  
Jognandan Prashar ◽  
Phillip Sharp ◽  
Mathew Scarffe ◽  
Bruce Cornell
Keyword(s):  
Lipid Bilayers ◽  
Lipid Membranes ◽  
Room Temperature ◽  
Materials Science ◽  
Lipid Phase ◽  
Molecular Sensing ◽  
Long Term Storage ◽  
Supported Lipid Membranes ◽  
Term Storage

Biosensors based on lipid membranes promise an inexpensive and versatile platform for application in many fields of molecular sensing. An extensive review of the applications for tethered membranes was reported in the July 2006 MRS Bulletin [A.N. Parikh and J.T. Groves, Materials science of supported lipid membranes. MRS Bull.31(8), 507 (2006)]. The commercial use to which tethered lipid membranes have been applied has been limited by their stability under long-term storage. This report describes a novel membrane construct that is stable at room temperature for months, eliminates the mobile lipid phase present in lipid bilayers, and is robust against detergents under conditions that would destroy a lipid bilayer.

scholarly journals Mimicking the Mammalian Plasma Membrane: An Overview of Lipid Membrane Models for Biophysical Studies

Biomimetics ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. 3
Author(s):  
Alessandra Luchini ◽  
Giuseppe Vitiello
Keyword(s):  
Plasma Membrane ◽  
Lipid Bilayers ◽  
Lipid Membranes ◽  
Cell Membranes ◽  
Lipid Membrane ◽  
Lipid Phase ◽  
Chemical Information ◽  
Lipid Species ◽  
Membrane Models ◽  
The Impact

Cell membranes are very complex biological systems including a large variety of lipids and proteins. Therefore, they are difficult to extract and directly investigate with biophysical methods. For many decades, the characterization of simpler biomimetic lipid membranes, which contain only a few lipid species, provided important physico-chemical information on the most abundant lipid species in cell membranes. These studies described physical and chemical properties that are most likely similar to those of real cell membranes. Indeed, biomimetic lipid membranes can be easily prepared in the lab and are compatible with multiple biophysical techniques. Lipid phase transitions, the bilayer structure, the impact of cholesterol on the structure and dynamics of lipid bilayers, and the selective recognition of target lipids by proteins, peptides, and drugs are all examples of the detailed information about cell membranes obtained by the investigation of biomimetic lipid membranes. This review focuses specifically on the advances that were achieved during the last decade in the field of biomimetic lipid membranes mimicking the mammalian plasma membrane. In particular, we provide a description of the most common types of lipid membrane models used for biophysical characterization, i.e., lipid membranes in solution and on surfaces, as well as recent examples of their applications for the investigation of protein-lipid and drug-lipid interactions. Altogether, promising directions for future developments of biomimetic lipid membranes are the further implementation of natural lipid mixtures for the development of more biologically relevant lipid membranes, as well as the development of sample preparation protocols that enable the incorporation of membrane proteins in the biomimetic lipid membranes.

Membrane deterioration during senescence

1997 ◽  
Vol 75 (6) ◽  
pp. 867-879 ◽  
Author(s):  
J. E. Thompson ◽  
C. D. Froese ◽  
Y. Hong ◽  
K. A. Hudak ◽  
M. D. Smith
Keyword(s):  
Lipid Bilayers ◽  
Liquid Crystalline ◽  
Cell Function ◽  
Membrane Lipids ◽  
Phase Changes ◽  
Lipid Phase ◽  
Protein Particle ◽  
Protein Particles ◽  
Lipid Metabolites ◽  
Plant Membranes

The lipid bilayers of plant membranes are normally liquid crystalline, reflecting the inherent rotational motion of membrane fatty acids at physiological temperature. With the onset of senescence, the chemical composition of membrane lipids changes resulting in lipid phase separations within the bilayer. These phase changes render the membranes leaky and lead to loss of essential ion gradients and impairment of cell function. The separation of lipid phases appears to be attributable to an accumulation of lipid metabolites in the bilayer that are formed during turnover and metabolism of membrane lipids. These metabolites are normally released from membranes as lipid–protein particles found in the cell cytosol and within organelles. The lipid–protein particles also contain catabolites of membrane proteins and appear to serve as a vehicle for removing lipid and protein metabolites that would otherwise destabilize the bilayer. They bear structural resemblance to oil bodies, which are abundant in oil seeds, and have been found in leaves, cotyledons, and petals as well as in insect and animal tissue. The accumulation of lipid metabolites in senescing membranes and ensuing separation of lipid phases appear to reflect impairment of lipid–protein particle release from membranes as tissues age and to be a seminal cause of membrane dysfunction with advancing senescence. Key words: lipid bilayer, lipid phase separation, lipid–protein particles, membrane, oil body, senescence.

Sign in / Sign up

Export Citation Format

Share Document