Dysregulation of G protein-coupled receptors in the intestine by nanoplastic exposure in Caenorhabditis elegans

2021 ◽  
Author(s):  
Yunhan Yang ◽  
Qiuli Wu ◽  
Dayong Wang
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Environmental Toxicants ◽  
G Protein Coupled

After the uptake, the environmental toxicants may cause the toxicity on organisms by activating or inhibiting certain G protein-coupled receptors (GPCRs). Nevertheless, the roles of GPCRs in mediating the response...

scholarly journals Whole-Genome Analysis of 60 G Protein-Coupled Receptors in Caenorhabditis elegans by Gene Knockout with RNAi

2003 ◽  
Vol 13 (19) ◽  
pp. 1715-1720 ◽  
Author(s):  
Christopher D. Keating ◽  
Neline Kriek ◽  
Margaret Daniels ◽  
Neville R. Ashcroft ◽  
Neil A. Hopper ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
Genome Analysis ◽  
Gene Knockout ◽  
G Protein Coupled Receptors ◽  
Whole Genome ◽  
Whole Genome Analysis ◽  
G Protein Coupled

scholarly journals Identification of a Conserved, Orphan G Protein-Coupled Receptor Required for Efficient Pathogen Clearance in Caenorhabditis elegans

2019 ◽  
Vol 87 (4) ◽  
Author(s):  
Alexandra Anderson ◽  
Yee Lian Chew ◽  
William Schafer ◽  
Rachel McMullan
Keyword(s):  
Caenorhabditis Elegans ◽  
Immune Responses ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled Receptor ◽  
Content Type ◽  
C Elegans ◽  
Host Immune Responses ◽  
Pathogen Clearance ◽  
G Protein Coupled

ABSTRACT G protein-coupled receptors contribute to host defense across the animal kingdom, transducing many signals involved in both vertebrate and invertebrate immune responses. While it has become well established that the nematode worm Caenorhabditis elegans triggers innate immune responses following infection with numerous bacterial, fungal, and viral pathogens, the mechanisms by which C. elegans recognizes these pathogens have remained somewhat more elusive. C. elegans G protein-coupled receptors have been implicated in recognizing pathogen-associated damage and activating downstream host immune responses. Here we identify and characterize a novel G protein-coupled receptor required to regulate the C. elegans response to infection with Microbacterium nematophilum. We show that this receptor, which we designate pathogen clearance-defective receptor 1 (PCDR-1), is required for efficient pathogen clearance following infection. PCDR-1 acts upstream of multiple G proteins, including the C. elegans Gαq ortholog, EGL-30, in rectal epithelial cells to promote pathogen clearance via a novel mechanism.

scholarly journals Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans

2015 ◽  
Vol 472 ◽  
pp. 30-36 ◽  
Author(s):  
David Salom ◽  
Pengxiu Cao ◽  
Yiyuan Yuan ◽  
Masaru Miyagi ◽  
Zhaoyang Feng ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
Isotopic Labeling ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled
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