Genotoxic and immunomodulatory effects in human white blood cells after ex vivo exposure to polystyrene nanoplastics

2020 ◽  
Vol 7 (11) ◽  
pp. 3431-3446
Author(s):  
Sandra Ballesteros ◽  
Josefa Domenech ◽  
Irene Barguilla ◽  
Constanza Cortés ◽  
Ricard Marcos ◽  
...  
Keyword(s):  
Blood Cells ◽  
Ex Vivo ◽  
White Blood Cells ◽  
Health Concern ◽  
Ecological Problem ◽  
Immunomodulatory Effects ◽  
P Accumulation ◽  
Human White Blood Cells

Accumulation of plastic and its derivatives, micro- and nanoplastics (MNPLs), is a substantial environmental and ecological problem that could potentially become a serious health concern to humans.

A new group of glucocerebrosidase isozymes found in human white blood cells

1980 ◽  
Vol 97 (3) ◽  
pp. 1103-1107 ◽  
Author(s):  
Edward I. Ginns ◽  
Roscoe O. Brady ◽  
Daniel W. Stowens ◽  
F.Scott Furbish ◽  
John A. Barranger
Keyword(s):  
Blood Cells ◽  
White Blood Cells ◽  
Human White Blood Cells

scholarly journals Identification of phosphatidylserine-binding proteins in human white blood cells

1990 ◽  
Vol 269 (3) ◽  
pp. 723-728 ◽  
Author(s):  
M Wolf ◽  
M Baggiolini
Keyword(s):  
Protein Kinase C ◽  
Blood Cells ◽  
Binding Proteins ◽  
White Blood Cells ◽  
Human Neutrophils ◽  
Kinase C ◽  
Sds Page ◽  
Molecular Masses ◽  
Human White Blood Cells ◽  
Monocytes And Lymphocytes

Cytosol and membrane fractions from human neutrophils, monocytes, lymphocytes and platelets were separated by SDS/PAGE, blotted on to nitrocellulose and assayed for selective binding of phosphatidylserine (PS). Two PS-binding proteins with apparent molecular masses of 115 kDa and 100 kDa were identified in the cytosol of neutrophils, monocytes and lymphocytes. Corresponding bands along with other PS-binding proteins were detected in platelets in both cytosol and membrane fractions. These proteins were also found to bind protein kinase C (PKC) provided that PS was present. The 115 kDa and 100 kDa proteins (PS-p115/110) were partially purified from neutrophils and were used for the study of PS and PKC binding. The binding of PS did not require Ca2+ or Mg2+ and was inhibited by phosphatidic acid, by 1-alkyl-2-acetylphosphocholine and, to a lesser extent, by other lipids. The binding of PKC, however, was strictly PS- and Ca2(+)-dependent and seems to occur secondarily to PS binding.

Expression of CD80 (B7/BB-1) and CD28 in human white blood cells treated with urocanic acid

1996 ◽  
Vol 288 (10) ◽  
pp. 570-574 ◽  
Author(s):  
Jarmo K. Laihia ◽  
Jaakko Uksila ◽  
Marko Luhtala ◽  
Christer T. Jansén
Keyword(s):  
Blood Cells ◽  
White Blood Cells ◽  
Urocanic Acid ◽  
Human White Blood Cells
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