Data mining of amine dehydrogenases for the synthesis of enantiopure amino alcohols

2020 ◽  
Vol 10 (17) ◽  
pp. 5945-5952
Author(s):  
Hongyue Wang ◽  
Ge Qu ◽  
Jun-Kuan Li ◽  
Jun-An Ma ◽  
Jinggong Guo ◽  
...  
Keyword(s):  
Data Mining ◽  
Amino Acid ◽  
Carbonyl Compounds ◽  
Amino Alcohols ◽  
Chiral Amino Alcohols

Five amine dehydrogenases (AmDHs) derived from amino acid dehydrogenases have been identified and evaluated for the stereoselective amination of α-/β-functionalized carbonyl compounds to synthesize chiral amino alcohols.

Simple and efficient synthesis of chiral amino alcohols with an amino acid-based skeleton

2003 ◽  
Vol 10 (2) ◽  
pp. 79-82 ◽  
Author(s):  
Paulina Juszczyk ◽  
Regina Kasprzykowska ◽  
Aleksandra S. Kołodziejczyk
Keyword(s):  
Amino Acid ◽  
Amino Alcohols ◽  
Efficient Synthesis ◽  
Chiral Amino Alcohols

Bile acid amides derived from chiral amino alcohols: novel antimicrobials and antifungals

2004 ◽  
Vol 14 (3) ◽  
pp. 773-777 ◽  
Author(s):  
BrajaG. Hazra ◽  
VandanaS. Pore ◽  
SanjeevKumar Dey ◽  
Suchitra Datta ◽  
MahendraP. Darokar ◽  
...  
Keyword(s):  
Bile Acid ◽  
Amino Alcohols ◽  
Chiral Amino Alcohols

Circular dichroism spectra of tetraamminecobalt(III) complexes of amino alcohols

1978 ◽  
Vol 31 (11) ◽  
pp. 2399 ◽  
Author(s):  
CJ Hawkins ◽  
GA Lawrance ◽  
JA Palmer
Keyword(s):  
Circular Dichroism ◽  
Chemical Shift ◽  
Chemical Shifts ◽  
Amino Alcohols ◽  
Circular Dichroism Spectra ◽  
Chemical Shift Difference ◽  
Solvent Dependence ◽  
Cotton Effects ◽  
Circular Dichroïsm ◽  
Chiral Amino Alcohols

The circular dichroism spectra are reported for tetraamminecobalt(III) complexes with the chiral amino alcohols 2-aminopropan-1-ol, 2- aminobutan-1-ol, 1-aminopropan-2-ol, 2-amino-1-phenyl-ethanol, ψ- ephedrine and ephedrine with the alcohol groups protonated (OH) and deprotonated (O-). The solvent dependence of the chemical shifts of the NH protons was investigated to determine the effects of stereoselective solvation on the circular dichroism, but, in contrast to some other related systems, the chemical shift difference between the two NH2 protons was relatively insensitive to solvent. Consistent with this, the circular dichroism spectra of the tetraphenylborate salts of the deprotonated complexes were found not to be markedly dependent on solvent. Tetraammine-{(-)-ψ-ephedrine)cobalt(III) and tetraammine{(-)- ephedrine}cobalt(III) were found to have the same signs of Cotton effects for the various d-d transitions, whereas bis{(-)-ψ- ephedrine}copper(II) and bis{(-)-ephedrine}copper(II) had opposite signs. This has been explained in terms of different conformer populations in the cobalt(III) and copper(II) systems.

scholarly journals De Novo Chiral Amino Alcohols in Catalyzing Asymmetric Additions to Aryl Aldehydes.

ChemInform ◽  
2006 ◽  
Vol 37 (35) ◽  
Author(s):  
Jian Huang ◽  
James C. Ianni ◽  
Jennifer E. Antoline ◽  
Richard P. Hsung ◽  
Marisa C. Kozlowski
Keyword(s):  
De Novo ◽  
Amino Alcohols ◽  
Aryl Aldehydes ◽  
Asymmetric Additions ◽  
Chiral Amino Alcohols

Sodium borohydride: A versatile reagent in the reductive N-monoalkylation of α-amino acids and α-amino methyl esters

2002 ◽  
Vol 80 (7) ◽  
pp. 779-788 ◽  
Author(s):  
Giancarlo Verardo ◽  
Paola Geatti ◽  
Elena Pol ◽  
Angelo G Giumanini
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Sodium Borohydride ◽  
Carbonyl Compounds ◽  
Condensation Reaction ◽  
Methyl Esters ◽  
Reducing Agent ◽  
Reductive Condensation ◽  
Versatile Reagent

α-Amino acids and α-amino methyl esters are easily converted to their N-monoalkyl derivatives by a reductive condensation reaction using several carbonyl compounds in the presence of sodium borohydride. This reducing agent has shown a wide versatility with minor but essential procedural variations. The reaction allows the α-monodeuterium labeling of the new N-substituent by use of sodium borodeuteride.Key words: α-amino acid, α-amino methyl esters, sodium borohydride, reductive N-monoalkylation, carbonyl compounds.

One-Pot Synthesis ofN-Protected β-Chiral Amino Alcohols

2003 ◽  
Vol 33 (11) ◽  
pp. 1815-1820 ◽  
Author(s):  
Csaba Somlai ◽  
Antal Péter ◽  
Péter Forgó ◽  
Botond Penke
Keyword(s):  
Amino Alcohols ◽  
One Pot ◽  
One Pot Synthesis ◽  
Chiral Amino Alcohols
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