Redesign of protein nanocages: the way from 0D, 1D, 2D to 3D assembly

2021 ◽  
Author(s):  
Chenyan Lv ◽  
Xiaorong Zhang ◽  
Yu Liu ◽  
Tuo Zhang ◽  
Hai Chen ◽  
...  

This review focuses on the design and construction of artificial protein nanocages, and their assembly into highly ordered supramolecules.

2021 ◽  
pp. 263497952110070
Author(s):  
Luke Lowings

The information contained in light from our surroundings is often taken for granted because of its ubiquity, and the subliminal nature of the way we normally use it. Revealing the richness and depth of our common human experience through the unexpected qualities of light is seen as an artistic opportunity. An architectural training enables the integration of a subjective and qualitative experience, with the ‘objective’ structures that we are surrounded by. The built space can act as a ‘neutral’ reference onto which the complexity of daylight is superimposed. The author, trained as an architect, has been involved for more than 30 years in the design and construction of non-gallery artworks that engage the experience of natural light in public and semi-public spaces. This practitioner reflection discusses the relation of the position of the observer and sources of light, and how the movement of the viewer acts as a catalyst for revealing their situation through six works of various scales that the author worked on in New York; Boston; Abu Dhabi; London; and Berlin.


Author(s):  
Marco Liboà

The paper focuses on how the design of the hardware supports and constrains the representation of graphics in videogames. The Sega Saturn was chosen as a platform of study due to the complexity of its internal circuitry and the period during which it was commercialised, characterised by a shift in the representation of game graphics from 2D to 3D. The peculiar characteristics of Saturn’s two video display processors and the way they shape the graphics of games developed for it are presented in a few selected examples. In particular, it illustrates how a 3D space can be simulated by means of 2D background layers, and how hardware limitations and different video-signals can affect the final rendering of game graphics. It concludes that different graphical techniques, present in a certain episode of a game series, could be absent in a direct sequel and then reappear all together in a later episode, leading to a non-linear technological innovation trajectory. Furthermore, it is ascertained that the Saturn hardware architecture influenced the efforts of developers in subtle and unexpected ways.


2019 ◽  
Author(s):  
Qiang Li ◽  
Kewang Nan ◽  
Paul Le Floch ◽  
Zuwan Lin ◽  
Hao Sheng ◽  
...  

ABSTRACTTissue-wide electrophysiology with single-cell and millisecond spatiotemporal resolution is critical for heart and brain studies, yet issues arise from invasive, localized implantation of electronics that destructs the well-connected cellular networks within matured organs. Here, we report the creation of cyborg organoids: the three-dimensional (3D) assembly of soft, stretchable mesh nanoelectronics across the entire organoid by cell-cell attraction forces from 2D-to-3D tissue reconfiguration during organogenesis. We demonstrate that stretchable mesh nanoelectronics can grow into and migrate with the initial 2D cell layers to form the 3D structure with minimal interruptions to tissue growth and differentiation. The intimate contact of nanoelectronics to cells enables us to chronically and systematically observe the evolution, propagation and synchronization of the bursting dynamics in human cardiac organoids through their entire organogenesis.


Author(s):  
Gerald Hodge

ABSTRACTProgrammes for publicly assisted housing for senior citizens are making it increasingly possible for the elderly to reside in towns and villages. A study of senior citizen apartment projects in nine small Ontario Towns appraises the quality of housing being produced. Many shortfalls in design and construction are revealed along with out-of-the-way locations for projects. Deficiencies are not easily rectified and responsibility impossible to assign.


2018 ◽  
Vol 41 ◽  
Author(s):  
Maria Babińska ◽  
Michal Bilewicz

AbstractThe problem of extended fusion and identification can be approached from a diachronic perspective. Based on our own research, as well as findings from the fields of social, political, and clinical psychology, we argue that the way contemporary emotional events shape local fusion is similar to the way in which historical experiences shape extended fusion. We propose a reciprocal process in which historical events shape contemporary identities, whereas contemporary identities shape interpretations of past traumas.


2020 ◽  
Vol 43 ◽  
Author(s):  
Aba Szollosi ◽  
Ben R. Newell

Abstract The purpose of human cognition depends on the problem people try to solve. Defining the purpose is difficult, because people seem capable of representing problems in an infinite number of ways. The way in which the function of cognition develops needs to be central to our theories.


1976 ◽  
Vol 32 ◽  
pp. 233-254
Author(s):  
H. M. Maitzen

Ap stars are peculiar in many aspects. During this century astronomers have been trying to collect data about these and have found a confusing variety of peculiar behaviour even from star to star that Struve stated in 1942 that at least we know that these phenomena are not supernatural. A real push to start deeper theoretical work on Ap stars was given by an additional observational evidence, namely the discovery of magnetic fields on these stars by Babcock (1947). This originated the concept that magnetic fields are the cause for spectroscopic and photometric peculiarities. Great leaps for the astronomical mankind were the Oblique Rotator model by Stibbs (1950) and Deutsch (1954), which by the way provided mathematical tools for the later handling pulsar geometries, anti the discovery of phase coincidence of the extrema of magnetic field, spectrum and photometric variations (e.g. Jarzebowski, 1960).


Author(s):  
W.M. Stobbs

I do not have access to the abstracts of the first meeting of EMSA but at this, the 50th Anniversary meeting of the Electron Microscopy Society of America, I have an excuse to consider the historical origins of the approaches we take to the use of electron microscopy for the characterisation of materials. I have myself been actively involved in the use of TEM for the characterisation of heterogeneities for little more than half of that period. My own view is that it was between the 3rd International Meeting at London, and the 1956 Stockholm meeting, the first of the European series , that the foundations of the approaches we now take to the characterisation of a material using the TEM were laid down. (This was 10 years before I took dynamical theory to be etched in stone.) It was at the 1956 meeting that Menter showed lattice resolution images of sodium faujasite and Hirsch, Home and Whelan showed images of dislocations in the XlVth session on “metallography and other industrial applications”. I have always incidentally been delighted by the way the latter authors misinterpreted astonishingly clear thickness fringes in a beaten (”) foil of Al as being contrast due to “large strains”, an error which they corrected with admirable rapidity as the theory developed. At the London meeting the research described covered a broad range of approaches, including many that are only now being rediscovered as worth further effort: however such is the power of “the image” to persuade that the above two papers set trends which influence, perhaps too strongly, the approaches we take now. Menter was clear that the way the planes in his image tended to be curved was associated with the imaging conditions rather than with lattice strains, and yet it now seems to be common practice to assume that the dots in an “atomic resolution image” can faithfully represent the variations in atomic spacing at a localised defect. Even when the more reasonable approach is taken of matching the image details with a computed simulation for an assumed model, the non-uniqueness of the interpreted fit seems to be rather rarely appreciated. Hirsch et al., on the other hand, made a point of using their images to get numerical data on characteristics of the specimen they examined, such as its dislocation density, which would not be expected to be influenced by uncertainties in the contrast. Nonetheless the trends were set with microscope manufacturers producing higher and higher resolution microscopes, while the blind faith of the users in the image produced as being a near directly interpretable representation of reality seems to have increased rather than been generally questioned. But if we want to test structural models we need numbers and it is the analogue to digital conversion of the information in the image which is required.


1979 ◽  
Vol 44 (1) ◽  
pp. 3-30 ◽  
Author(s):  
Carol A. Pruning

A rationale for the application of a stage process model for the language-disordered child is presented. The major behaviors of the communicative system (pragmatic-semantic-syntactic-phonological) are summarized and organized in stages from pre-linguistic to the adult level. The article provides clinicians with guidelines, based on complexity, for the content and sequencing of communicative behaviors to be used in planning remedial programs.


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