scholarly journals Detection of coronavirus in environmental surveillance and risk monitoring for pandemic control

2021 ◽  
Vol 50 (6) ◽  
pp. 3656-3676 ◽  
Author(s):  
Linlin Yao ◽  
Wenting Zhu ◽  
Jianbo Shi ◽  
Tailin Xu ◽  
Guangbo Qu ◽  
...  
Keyword(s):  
Environmental Surveillance ◽  
Environmental Transmission ◽  
Risk Monitoring ◽  
Novel Coronavirus

A schematic illustration of the environmental transmission of novel coronavirus (SARS-CoV-2 as an example) under different scenarios during the COVID-19 pandemic.

scholarly journals Risk Management Analysis for Novel Coronavirus in Wuhan, China

2020 ◽  
Vol 13 (2) ◽  
pp. 22 ◽  
Author(s):  
Xiao-Guang Yue ◽  
Xue-Feng Shao ◽  
Rita Li ◽  
M. Crabbe ◽  
Lili Mi ◽  
...  
Keyword(s):  
Risk Management ◽  
Early Warning ◽  
International Policy ◽  
Policy Makers ◽  
Risk Monitoring ◽  
Institutional Cooperation ◽  
Novel Coronavirus

Recently, a novel coronavirus pneumonia (2019–nCoV) outbreak occurred in Wuhan, China, rapidly spreading first to the whole country, and then globally, causing widespread concern. From the perspectives of early warning and identification of risk, risk monitoring, and analysis, as well as risk management and handling, we propose corresponding solutions and recommendations, which include institutional cooperation, and to inform national and international policy-makers.

Ergebnisse der COVID-19-Umfrage der Deutschen Gesellschaft für Rehabilitationswissenschaften e.V. (DGRW)

2020 ◽  
Vol 59 (05) ◽  
pp. 315-317
Author(s):  
Thorsten Meyer ◽  
Elain Posthumus ◽  
Keyword(s):  
Public Health ◽  
Global Literature ◽  
Novel Coronavirus

Hintergrund und ZielCOVID-19 stellt eine substanzielle Bedrohung der Gesundheit und in der Folge auch der Lebensbedingungen der Menschen weltweit dar. Die Erkrankung entsteht infolge einer Infektion mit dem neuartigen Coronavirus SARS-CoV-2. Erkenntnisse über molekulare Grundlagen, Pathophysiologie, klinische Charakteristika, Epidemiologie, aber auch Ressourcenbedarf und Outcomes (z. B. Karagiannidis et al. 2020; zur Übersicht s. Website der WHO: https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/) wachsen in beispiellos kurzem Zeitraum weltweit an, auch im Feld der Rehabilitation (vgl. Negrini et al. 2020). Die Erkenntnisse münden in Leitlinien, Policy Briefs oder konkreten Handlungsempfehlungen (vgl. Publikationen des Kompetenznetz Public Health COVID-19, www.public-health-covid19.de).

The environmental transmission of cholera

Waterlines ◽  
1994 ◽  
Vol 12 (4) ◽  
pp. 4-7
Author(s):  
Ann storey
Keyword(s):  
Environmental Transmission

Experience in Applying Hyperbaric Oxygen Therapy Using Portable Pressure Chambers for the Treatment of Patients with the Novel Coronavirus Infection COVID-19

Biomeditsina ◽  
2020 ◽  
pp. 39-46
Author(s):  
A. S. Samoilov ◽  
Yu. D. Udalov ◽  
M. V. Sheyanov ◽  
A. V. Gholinsky ◽  
A. B. Litvinenko
Keyword(s):  
Oxygen Saturation ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Capillary Blood ◽  
Blood Hemoglobin ◽  
Patient Groups ◽  
Radiological Changes ◽  
Coronavirus Infection ◽  
Novel Coronavirus

This communication presents the experience of using mobile pressure chambers in patients with the confi rmed novel coronavirus infection in hospital settings. The obtained preliminary results indicate positive antihypoxic effects of hyperbaric oxygen therapy (HBO) applied in the form of increased saturation. After a session of HBO, patients demonstrated an increase in the oxygen saturation of capillary blood hemoglobin at the average level of 3.71 points. Differences between SatO2 levels prior to and following HBO treatment were signifi cant in the CT2, CT3 and CT4 groups (p0.05). As expected, the effi cacy of HBO in terms of the oxygen saturation of capillary blood hemoglobin was the greatest in the patient groups showing pronounced clinical and radiological changes in the lungs.

Drug Repurposing Studies Targeting SARS-nCoV2: An Ensemble Docking Approach on Drug Target 3C-like Protease (3CLpro)

2020 ◽  
Author(s):  
Shruti Koulgi ◽  
Vinod Jani ◽  
Mallikarjunachari Uppuladinne ◽  
Uddhavesh Sonavane ◽  
Asheet Kumar Nath ◽  
...  
Keyword(s):  
Drug Repurposing ◽  
Drug Binding ◽  
Ensemble Docking ◽  
Drug Molecules ◽  
Drug Binding Site ◽  
Main Protease ◽  
Docking Approach ◽  
Novel Coronavirus ◽  
Markov State Modeling ◽  
Viral Polyprotein

<p>The COVID-19 pandemic has been responsible for several deaths worldwide. The causative agent behind this disease is the Severe Acute Respiratory Syndrome – novel Coronavirus 2 (SARS-nCoV2). SARS-nCoV2 belongs to the category of RNA viruses. The main protease, responsible for the cleavage of the viral polyprotein is considered as one of the hot targets for treating COVID-19. Earlier reports suggest the use of HIV anti-viral drugs for targeting the main protease of SARS-CoV, which caused SARS in the year 2002-03. Hence, drug repurposing approach may prove to be useful in targeting the main protease of SARS-nCoV2. The high-resolution crystal structure of 3CL<sup>pro</sup> (main protease) of SARS-nCoV2 (PDB ID: 6LU7) was used as the target. The Food and Drug Administration (FDA) approved and SWEETLEAD database of drug molecules were screened. The apo form of the main protease was simulated for a cumulative of 150 ns and 10 μs open source simulation data was used, to obtain conformations for ensemble docking. The representative structures for docking were selected using RMSD-based clustering and Markov State Modeling analysis. This ensemble docking approach for main protease helped in exploring the conformational variation in the drug binding site of the main protease leading to efficient binding of more relevant drug molecules. The drugs obtained as best hits from the ensemble docking possessed anti-bacterial and anti-viral properties. Small molecules with these properties may prove to be useful to treat symptoms exhibited in COVID-19. This <i>in-silico</i> ensemble docking approach would support identification of potential candidates for repurposing against COVID-19.</p>

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

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