Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds

2021 ◽  
Author(s):  
Rolando Cannalire ◽  
Sveva Pelliccia ◽  
Luca Sancineto ◽  
Ettore Novellino ◽  
Gian Cesare Tron ◽  
...  
Keyword(s):  
Visible Light ◽  
Bioactive Compounds ◽  
Late Stage ◽  
Visible Light Photocatalysis ◽  
Future Prospects ◽  
Recent Developments

Recent developments and future prospects of visible-light photocatalysis in the late-stage functionalization of pharmaceuticals and natural bioactive compounds.

Synthesis and absolute configuration assignment of albucidin: a late-stage reductive deiodination by visible light photocatalysis

2016 ◽  
Vol 14 (13) ◽  
pp. 3482-3485 ◽  
Author(s):  
Hu Zhang ◽  
Peng-Fei Liu ◽  
Qiong Chen ◽  
Qiong-You Wu ◽  
Anne Seville ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Visible Light ◽  
Absolute Configuration ◽  
Late Stage ◽  
Visible Light Photocatalysis ◽  
Configuration Assignment ◽  
Bioactive Molecule ◽  
The Way

The total synthesis and absolute configuration assignment of albucidin might pave the way for synthetic and medicinal chemists for further research on this type of bioactive molecule.

Enantioselective synthesis enabled by visible light photocatalysis

2020 ◽  
Vol 18 (23) ◽  
pp. 4298-4353 ◽  
Author(s):  
Bor-Cherng Hong
Keyword(s):  
Visible Light ◽  
Asymmetric Synthesis ◽  
Enantioselective Synthesis ◽  
Visible Light Photocatalysis ◽  
Recent Developments

This review summarizes recent developments in visible-light enantioselective photocatalysis reactions, which provide convenient and effective tools for asymmetric synthesis.

scholarly journals Visible light mediated photocatalytic [2 + 2] cycloaddition/ring-opening rearomatization cascade of electron-deficient azaarenes and vinylarenes

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Noelia Salaverri ◽  
Rubén Mas-Ballesté ◽  
Leyre Marzo ◽  
José Alemán
Keyword(s):  
Natural Products ◽  
Double Bond ◽  
Visible Light ◽  
Bioactive Compounds ◽  
Late Stage ◽  
Ring Opening ◽  
Functional Group ◽  
Theoretical Calculations ◽  
Double Bonds ◽  
Heterocyclic Derivatives

Abstract The broad presence of azaarene moieties in natural products has promoted the development of new functionalization reactions, giving access to larger libraries of bioactive compounds. The light promoted [2 + 2] photocycloaddition reaction to generate cyclobutanes has been extensively studied in photochemistry. In particular, De Mayo reported the [2 + 2] cycloaddition followed by retroaldol condensation between enols of 1,3-dicarbonyls and double bonds to synthesize 1,5-dicarbonyls. Herein, we describe the [2 + 2] photocycloaddition followed by a ring-opening rearomatization reaction between electron-deficient 2-methylene-azaarenes and double bonds, taking advantage of the ability of these heterocyclic derivatives to form the corresponding pseudo-enamine intermediate. The procedure shows a high functional group tolerance either on the double bond or the heteroarene side and allows the presence of different electron-withdrawing groups. In addition, the wide applicability of this reaction has been demonstrated through the late-stage derivatization of several natural products. Photochemical studies, together with theoretical calculations, support a mechanism involving the photosensitization of the pseudo-enamine intermediate.

Semiconductor Photocatalysts for Solar-to-Hydrogen Energy Conversion: Recent Advances of CdS

2020 ◽  
Vol 16 ◽  
Author(s):  
Yuxue Wei ◽  
Honglin Qin ◽  
Jinxin Deng ◽  
Xiaomeng Cheng ◽  
Mengdie Cai ◽  
...  
Keyword(s):  
Hydrogen Production ◽  
Visible Light ◽  
Hydrogen Evolution ◽  
Water Splitting ◽  
Visible Light Irradiation ◽  
Noble Metals ◽  
Light Irradiation ◽  
Photocatalytic Hydrogen Evolution ◽  
Theoretical Design ◽  
Recent Developments

Introduction: Solar-driven photocatalytic hydrogen production from water splitting is one of the most promising solutions to satisfy the increasing demands of a rapidly developing society. CdS has emerged as a representative semiconductor photocatalyst due to its suitable band gap and band position. However, the poor stability and rapid charge recombination of CdS restrict its application for hydrogen production. The strategy of using a cocatalyst is typically recognized as an effective approach for improving the activity, stability, and selectivity of photocatalysts. In this review, recent developments in CdS cocatalysts for hydrogen production from water splitting under visible-light irradiation are summarized. In particular, the factors affecting the photocatalytic performance and new cocatalyst design, as well as the general classification of cocatalysts, are discussed, which includes a single cocatalyst containing noble-metal cocatalysts, non-noble metals, metal-complex cocatalysts, metal-free cocatalysts, and multi-cocatalysts. Finally, future opportunities and challenges with respect to the optimization and theoretical design of cocatalysts toward the CdS photocatalytic hydrogen evolution are described. Background: Photocatalytic hydrogen evolution from water splitting using photocatalyst semiconductors is one of the most promising solutions to satisfy the increasing demands of a rapidly developing society. CdS has emerged as a representative semiconductor photocatalyst due to its suitable band gap and band position. However, the poor stability and rapid charge recombination of CdS restrict its application for hydrogen production. The strategy of using a cocatalyst is typically recognized as an effective approach for improving the activity, stability, and selectivity of photocatalysts. Methods: This review summarizes the recent developments in CdS cocatalysts for hydrogen production from water splitting under visible-light irradiation. Results: Recent developments in CdS cocatalysts for hydrogen production from water splitting under visible-light irradiation are summarized. The factors affecting the photocatalytic performance and new cocatalyst design, as well as the general classification of cocatalysts, are discussed, which includes a single cocatalyst containing noble-metal cocatalysts, non-noble metals, metal-complex cocatalysts, metal-free cocatalysts, and multi-cocatalysts. Finally, future opportunities and challenges with respect to the optimization and theoretical design of cocatalysts toward the CdS photocatalytic hydrogen evolution are described. Conclusion: The state-of-the-art CdS for producing hydrogen from photocatalytic water splitting under visible light is discussed. The future opportunities and challenges with respect to the optimization and theoretical design of cocatalysts toward the CdS photocatalytic hydrogen evolution are also described.

Rhodamines as Photocatalyst in Organic Synthesis

2020 ◽  
Vol 07 ◽  
Author(s):  
Avik K. Bagdi ◽  
Papiya Sikdar
Keyword(s):  
Visible Light ◽  
Organic Synthesis ◽  
Organic Dyes ◽  
Transition Metal Catalysts ◽  
Visible Light Photocatalysis ◽  
Eosin Y ◽  
Organic Transformations ◽  
The Sustainable Development ◽  
Mechanistic Pathway ◽  
Green Model

Abstract:: Organic synthesis under environment friendly conditions has great impact in the sustainable development. In this context, visible light photocatalysis has emerged as a green model as this offers an energy-efficient pathway towards the organic transformation. Different transition-metal catalysts (Ir-, Ru-, Cu- etc) and organic dyes (eosin Y, rose bengal, methylene blue etc) are well-known photocatalysts in organic synthesis. Apart from the well-known organophotoredox catalysts, rhodamines (Rhodamine B and Rhodamine 6G) have been also employed as efficient photocatalysts for different organic transformations. In this review, we will focus on the photocatalysis by rhodamines in organic synthesis. Mechanistic pathway of the methodologies will also be discussed. We believe this review will stimulate the employment of rhodamines in the visible light photocatalysis for efficient organic transformations in the future.

Carbon quantum dot-sensitized hollow TiO2 spheres for high-performance visible light photocatalysis

2021 ◽  
Author(s):  
Xianfeng Zhang ◽  
Zongqun Li ◽  
Shaowen Xu ◽  
Yaowen Ruan
Keyword(s):  
Quantum Dots ◽  
Quantum Dot ◽  
Visible Light ◽  
Photocatalytic Degradation ◽  
High Performance ◽  
Carbon Quantum Dots ◽  
Visible Light Photocatalysis ◽  
Carbon Quantum Dot ◽  
Visible Light Photocatalytic

TiO2/CQD composites were synthesized through carbon quantum dots covalently attached to the surface of hollow TiO2 spheres for visible light photocatalytic degradation of organics.

scholarly journals Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1145
Author(s):  
Yuan Zhao ◽  
Xuecheng Zhu ◽  
Wei Jiang ◽  
Huilin Liu ◽  
Baoguo Sun
Keyword(s):  
Rapid Development ◽  
Chiral Molecules ◽  
Future Prospects ◽  
Chiral Drugs ◽  
Recognition Mechanism ◽  
Practical Applications ◽  
Food Industries ◽  
Global Industry ◽  
Endocrine Disrupting ◽  
Recent Developments

With the rapid development of global industry and increasingly frequent product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important. The chiral nature of substances can result in harm to the human body, and the selective endocrine-disrupting effect of drug enantiomers is caused by differential enantiospecific binding to receptors. This review is devoted to the specific recognition and resolution of chiral molecules by chromatography and membrane-based enantioseparation techniques. Chromatographic enantiomer separations with chiral stationary phase (CSP)-based columns and membrane-based enantiomer filtration are detailed. In addition, the unique properties of these chiral resolution methods have been summarized for practical applications in the chemistry, environment, biology, medicine, and food industries. We further discussed the recognition mechanism in analytical enantioseparations and analyzed recent developments and future prospects of chromatographic and membrane-based enantioseparations.

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