Efficiency analysis of helium-cooled MAS DNP: case studies of surface-modified nanoparticles and homogeneous small-molecule solutions

2021 ◽  
Vol 23 (8) ◽  
pp. 4919-4926
Author(s):  
Yoh Matsuki ◽  
Takeshi Kobayashi ◽  
Jun Fukazawa ◽  
Frédéric A. Perras ◽  
Marek Pruski ◽  
...  
Keyword(s):  
Case Studies ◽  
Heterogeneous Catalyst ◽  
Small Molecule ◽  
Efficiency Analysis ◽  
Time Performance ◽  
Surface Modified ◽  
Surface Modified Nanoparticles

DNP enhancement, paramagnet-induced quenching/depolarization and build-up times are studied in a heterogeneous catalyst between 30 and 100 K. He-cooled MAS DNP at 30 K provides up to 100-fold better time performance than N2-cooled MAS DNP at 90 K.

Impact of Surface-Modified Nanoparticles on Glass Transition Temperature and Elastic Modulus of Polymer Thin Films

2007 ◽  
Vol 40 (22) ◽  
pp. 7755-7757 ◽  
Author(s):  
Jong-Young Lee ◽  
Kristin E. Su ◽  
Edwin P. Chan ◽  
Qingling Zhang ◽  
Todd Emrick ◽  
...  
Keyword(s):  
Thin Films ◽  
Glass Transition ◽  
Elastic Modulus ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Polymer Thin Films ◽  
Surface Modified ◽  
Surface Modified Nanoparticles

scholarly journals Towards Academic Drug Development Guidelines

2019 ◽  
Author(s):  
Christopher Southan
Keyword(s):  
Drug Development ◽  
Success Rate ◽  
Case Studies ◽  
Small Molecule ◽  
Research Productivity ◽  
Medicinal Chemistry ◽  
Academic Development ◽  
Commercial Development ◽  
Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

scholarly journals Towards Academic Drug Development Guidelines

2019 ◽  
Author(s):  
Christopher Southan
Keyword(s):  
Drug Development ◽  
Success Rate ◽  
Case Studies ◽  
Small Molecule ◽  
Research Productivity ◽  
Medicinal Chemistry ◽  
Academic Development ◽  
Commercial Development ◽  
Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

Gram‐Negative Bacteria Targeting Mediated by Carbohydrate–Carbohydrate Interactions Induced by Surface‐Modified Nanoparticles

2019 ◽  
Vol 29 (48) ◽  
pp. 1904216 ◽  
Author(s):  
Larissa Brentano Capeletti ◽  
Jessica Fernanda Affonso Oliveira ◽  
Lívia Mesquita Dias Loiola ◽  
Flávia Elisa Galdino ◽  
Denys Ewerton Silva Santos ◽  
...  
Keyword(s):  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Surface Modified ◽  
Surface Modified Nanoparticles

Case studies in rare disease small molecule discovery and development

2020 ◽  
Vol 30 (21) ◽  
pp. 127462
Author(s):  
Darby Schmidt ◽  
Christopher Thompson
Keyword(s):  
Rare Disease ◽  
Case Studies ◽  
Small Molecule
Sign in / Sign up

Export Citation Format

Share Document